“…Other PRC proteins, PHC1 and PHC2, are important in NCC formation and patterning craniofacial skeletal elements by regulating Hox expression (Isono et al, 2005; Marc et al, 2023). These two factors have also been associated with congenital diseases including CATCH‐22 syndrome (PHC1) as well as patients presenting with DiGeorge syndrome‐like phenotypes (PHC1) and nonsyndromic cleft lip and palate (PHC2; Marc et al, 2023; Shirai et al, 2002; Takihara et al, 1997; Wilson et al, 1993). ASXL proteins (Additional sex combs‐like) ASXL1/2/3, which serve as scaffolds in the PRC complex, have important roles in early neural crest development, from generation of neural crest to delamination and emigration (Lichtig et al, 2020; Matheus et al, 2019).…”