Ii. Renal Function Influenced by Proteose Intoxication

Abstract

The injection of the toxic proteose obtained from the contents of the obstructed small intestine causes a definite impairment of the eliminative function of the kidneys as shown by a decreased capacity to excrete urea, sodium chloride, and phenolsulfonephthalein. This involvement of the renal function is similar to that shown by the preceding report (1) to accompany the intoxication of intestinal obstruction. The observed depression of function is readily demonstrable even when large amounts of fluid and urea, dye, or salt are injected directly into the blood stream. There is in all probability a temporary injury of the kidney cells, since the most important extrarenal factors have been largely eliminated in the above experiments. There is no appreciable impairment of the renal function following the injection of a number of other proteose preparations from a variety of sources. This study affords new evidence in favor of the view that the function of an organ can be profoundly disturbed for a time without any demonstrable anatomical lesions. The repair of this type of injury promptly follows the disappearance of the intoxication and is functionally and anatomically perfect.

Intravenous Injections of Foreign Protein in Influenzal Pneumonia

“…It is removed by means of a thread left hanging through the urethra. 1 For cancer of the prostate, Barringer plunges long needles through the perineum directly into the prostate, leaving them about twelve hours, the patient being under local anesthesia. Marion3 uses a large hydrocele trocar in a similar manner, plunging it through the perineum, its point being guided by a finger in the rectum.…”