IgG intrathecal synthesis and specific antibody index in patients with neurocysticercosis

Machado, L. R.; Livramento, José Antônio; Vaz, Adelaide José; Bueno, Ednéia Casagranda; Mielli, Sylvia Regina; Bastouly, V.; Nobrega, J. P. S.

doi:10.1590/s0004-282x2002000300011

Cited by 17 publications

(15 citation statements)

References 26 publications

(31 reference statements)

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“…The most frequent CSF alterations are mononuclear pleocytosis and the presence of eosinophils and specific antibodies which characterize the CSF syndrome of NCC [18]. The appearance of pleocytosis and specific antibodies in the CSF coincides with the degenerating stage of cysticerci and intensification of the host immune-inflammatory response [12].…”

Section: Diagnosismentioning

confidence: 99%

Therapy for neurocysticercosis

Takayanagui

2004

Expert Review of Neurotherapeutics

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Section: Diagnosismentioning

confidence: 99%

Therapy for neurocysticercosis

Takayanagui

2004

Expert Review of Neurotherapeutics

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“…112,113 Also, there may be intrathecally produced antigens in the CSF, particularly during antiparasitic treatment. [114][115][116][117][118][119] Venipuncture is the preferred collection method for clinical laboratory studies; however, blood can be also collected by finger prick on filter paper. This procedure is quite advantageous for sample storage and transport and is quite well accepted by the population and can be of great use in field studies or whenever venipuncture is not possible.…”

mentioning

confidence: 99%

Immunological and molecular diagnosis of cysticercosis

Rodríguez¹,

Wilkins

Dorny

2012

Pathogens and Global Health

133

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Cysticercosis, the infection with the larval stage of Taenia solium, is a cause of neurological symptoms including seizures, affecting the quality of life of patients and their families. Diagnosis focuses on brain imaging and serological tests are mostly used as confirmatory tools. Most cases, however, occur in poor endemic areas, where both kinds of diagnostic tools are poorly available. Development of point of care diagnostic tests is one of the most important priorities for cysticercosis researches today. The ideal point of care test would require detection of viable cysticercosis and hopefully identify cases with severe or progressive forms of neurocysticercosis, leading to referral of the patient for specialized medical attention. This manuscript describes the evolution of the serological diagnosis of cysticercosis over time, and the characteristics of the most common currently available tools, their advantages and disadvantages, and their potential use in future diagnostic tests.

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“…Antigen preparations with contamination of pig proteins, a common problem when T. solium cysts are used, are avoided using antigens obtained from larvae of T. crassiceps 2,19,20 .…”

Section: Discussionmentioning

confidence: 99%

Influence of the cerebrospinal fluid laboratory parameters in the ELISA test for neurocysticercosis using a total cysticerci antigen

Casanova

Ribeiro

Goncalves

et al. 2006

Arq. Neuro-Psiquiatr.

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-To evaluate if the cere b rospinal fluid (CSF) parameters may influence the cysticercosis immunoreactivity response in the CSF. CSF samples of 109 patients were analyzed and classified in three gro u p s , a c c o rding to the neurological manifestations and the reactivity in antibody-enzyme linked immunosorbent assay (Ab-ELISA) testing in CSF for neuro c y s t i c e rcosis (NC): group A, 18 patients with neurological diso rders compatible with NC and reactive Ab-ELISA in CSF for NC; group B, 50 patients with neurological disorders non-compatible with NC and reactive Ab-ELISA for NC; group C, 41 patients with neurological disorders non-compatible with NC and non-reactive Ab-ELISA in CSF for NC. The CSF analysis in group A was compatible with NC. The group B in comparison to the groups A and C presents higher frequency and intensity of hypercytosis, presence of red blood cells in CSF, protein concentration and immunological re a ctive test for other etiological agents (p 0.05). Based on the present data, we suggest that the inflammat o ry process and high protein concentration may determine false positive reactions in the Ab-ELISA test for NC in the CSF.KEY WORDS: cerebrospinal fluid, enzyme linked immunosorbent assay, neurocysticercosis. Influência dos parâmetros laboratoriais do líquido cefalorraquidiano no teste ELISA para neurocisticercose utilizando antígeno total de cisticerco RESUMO -Avaliar se os parâmetros do líquido cefalorraquidiano (LCR) podem influenciar na re a t i v i d a d e da resposta imune específica do LCR na neuro c i s t i c e rcose (NC). Amostras de LCR de 109 pacientes foramanalisadas e classificadas em três grupos, de acordo com as manifestações neurológicas e reatividade do teste de Ab-ELISA para NC no LCR. Grupo A, 18 pacientes com enfermidades neurológicas compatíveis com NC e reatividade do teste Ab-ELISA para NC no LCR; grupo B, 50 pacientes com enfermidades neuro l ó g icas não compatíveis com NC e reatividade do teste Ab-ELISA para NC no LCR; grupo C, 41 pacientes com e n f e rmidades neurológicas não compatíveis com NC e na ausência de reatividade do teste de Ab-ELISA para NC no LCR. A análise do LCR do grupo A foi compatível com NC. O grupo B apresentou maior freqüência e intensidade da pleocitose, da presença de hemácias no LCR, hiperpro t e i n o rraquia, re a t i v i d a d e imune para outros agentes etiológicos em comparação aos grupos A e C (p 0.05). Os dados indicam que o processo inflamatório e os elevados níveis de concentração da proteína no LCR podem influenciar na ocorrência de reações falso positivas de Ab-ELISA para NC. Destacamos a importância da correlação clíni-co-laboratorial para o diagnóstico de neurocisticercose e o uso de testes laboratoriais confirmatórios. PALAVRAS-CHAVE: líquido cefalorraquidiano, ensaio imunoenzimático, neurocisticercose.

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IgG intrathecal synthesis and specific antibody index in patients with neurocysticercosis

Cited by 17 publications

References 26 publications

Therapy for neurocysticercosis

Therapy for neurocysticercosis

Immunological and molecular diagnosis of cysticercosis

Influence of the cerebrospinal fluid laboratory parameters in the ELISA test for neurocysticercosis using a total cysticerci antigen

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