Influence of the cerebrospinal fluid laboratory parameters in the ELISA test for neurocysticercosis using a total cysticerci antigen

Casanova, Cristiane S.; Ribeiro, Maria José; Goncalves, R. R.; Faria, Luiz Claudio Silva de; Peralta, José Mauro; Puccioni-Sohler, Márzia

doi:10.1590/s0004-282x2006000100012

Cited by 3 publications

(2 citation statements)

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“…Several studies have shown that the performance of the ELISA method for diagnosis of neurocysticercosis is better in the stages of cysticercus degeneration [18][19][20] . These results are different from the present study, where six of the 15 patients with negative ELISA presented cysts in degeneration, while only one of the seven patients with positive ELISA presented cysts in degeneration.…”

Section: Carvalho-junior Rm Et Al -Enzyme Immunoassay For Diagnosis Omentioning

confidence: 99%

“…Reviewing the literature, it appears that the ELISA method has shown different sensitivity and specificity scores [17][18][19][20][21][22][23][24][25][26][27][28] . This study determined a sensitivity of 31.8% and specificity of 100% for the ELISA method in CSF in relation to diagnosing neurocysticercosis, which implies low sensitivity of ELISA for diagnosing neurocysticercosis, with a 68.3% rate of false negative.…”

Section: Carvalho-junior Rm Et Al -Enzyme Immunoassay For Diagnosis Omentioning

confidence: 99%

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Evaluation of an enzyme immunoassay for clinical diagnosis of neurocysticercosis in symptomatic patients

Carvalho

Costa

Soares³

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction: Neurocysticercosis is an infection of the human central nervous system caused by the metacestode larvae of Taenia solium. Neurocysticercosis is the most common parasitic disease in developing countries. Epilepsy is the most common clinical manifestation. Difficulties in confirming the diagnosis motivated the evaluation of the enzyme-linked immunosorbent assay on cerebral spinal fluid (CSF). Methods: Twenty-two patients with NCC and 44 control patients were studied. CSF was analyzed using a commercial ELISA kit developed for NCC. Sensitivity and specificity were measured and a multivariate logistic regression was performed. Results: Sensitivity and specificity of ELISA were 31.8% and 100%, respectively, with accuracy of 77.3%. Only the size of the lesions proved to be important for performance of the test. Conclusions:The results showed that ELISA contributes to the diagnosis of neurocysticercosis if the result is negative or if the patient has a lesion of 2 cm or more.

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Section: Carvalho-junior Rm Et Al -Enzyme Immunoassay For Diagnosis Omentioning

confidence: 99%