IgE against HIV proteins in clinically healthy children with HIV disease

Laboratorial atopy markers in children with human immunodeficiency virus

“…However, most of these studies are focused on adults with only one diagnostic test and a single evaluation. Some have considered personal history of allergic diseases as a diagnosis (Wright et al 1990, Ellaurie et al 1995, Lin & Lazarus 1995, Secord et al 1996, whereas others have used labo- Secord et al 1996), whereas others have used laboratory techniques, such as the prick test, or studied specific IgE for environmental allergens (Nissen et al 1999, Corominas et al 2000. This study was based on a group of infected children using environmental allergen prick test results as the criterion for defining the presence or absence of atopy.…”

Unique Inflammatory Mediators and Specific IgE Levels Distinguish Local from Systemic Reactions after Anthrax Vaccine Adsorbed Vaccination

“…An increase in IgE levels of this magnitude is likely to be biologically and clinically significant and may be related to the etiology of the LLRs. For instance, a similar increase in HIV-1-specific IgE correlates with reduced virus production (37), decreased opportunistic infections, and a better quality of life for individuals infected with HIV (38). Proving a direct causal relationship between an antigenspecific IgE and an AE is difficult, and further investigations are necessary to determine a possible mechanism (39).…”

Are Mast Cells MASTers in HIV-1 Infection?

“…Studies in various geographical regions have reported elevated serum IgE concentrations in HIV-1-infected adults [21, 28, 29, 30, 31, 32, 33]and children [22, 23, 24, 25, 26, 27]. High IgE levels have been associated with disease progression in both children [22, 23, 24, 25, 26, 27]and adults [33, 34, 35, 36, 37, 38, 39, 40, 41, 42]and have been suggested as a marker of poor prognosis in these patients.…”

“…While there is no apparent relation between these two disorders, a number of features of HIV infection suggest that hypersensitivity arises in these patients. For example, the Th1 and Th2 cytokine profile is deranged in HIV-1 infection because of a shift towards Th2 cytokines [13, 14, 15, 16, 17, 18, 19, 20, 21], and serum IgE levels are raised in HIV-1-infected children [22, 23, 24, 25, 26, 27]and adults [21, 28, 29, 30, 31, 32, 33]. Moreover, HIV-1-infected patients have enhanced symptoms of allergic disorders [34, 35, 36]and HIV-1 antigens induce histamine release from basophils [4, 37, 38].…”