Laboratorial atopy markers in children with human immunodeficiency virus

Cruz, Cristina Rodrigues; Carvalho, Vânia Oliveira; Santos, R. Vieira dos; Tahan, Tony Tannous; Vilela, Carlos Ribeiro; Lima, Hermenio C.

doi:10.1590/s0074-02762010000300008

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…There was a high frequency of raised total IgE in 40.7% of our study population, which corroborates the findings of other studies that used pediatric populations with HIV [8,11,17,18]. In addition, the groups with raised IgE levels presented more clinically advanced stages than the normal IgE group; however, no difference was detected in terms of immunological staging.…”

Section: Discussionsupporting

confidence: 90%

“…The most frequent symptom was rhinitis, followed by asthma and eczema. Studies have shown a prevalence of allergic disease in the pediatric population with HIV that ranged from 10% to 52% [8,9,17-19]. These studies used various methods to diagnose allergy, including atopy investigation using total IgE titration [8,17,18], RAST [18] and/or skin patch testing for allergens [8,9,19].…”

Section: Discussionmentioning

confidence: 99%

“…It seems, however, that atopy in HIV-infected children may be in part modulated by genetic and environmental factors, or even by immunological conditions. It is plausible that reactivity to environmental allergens may undergo positive and negative modifications associated with T-helper 2 (Th2)-linked immune changes [8]. On the other hand, when immunological parameters, such as total serum immunoglobulin E (IgE), are investigated, high levels of this immunoglobulin are found to be related to HIV disease progression [9,10] and the presence of HIV antigen specific IgE [11].…”

Section: Introductionmentioning

confidence: 99%

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Allergic diseases in subjects under 18 years living with HIV

Linhar

Traebert

Galato

et al. 2014

All Asth Clin Immun

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BackgroundIn recent decades there has been an increase in the prevalence of allergic disease. Manifestations of these diseases have allegedly been observed in people living with Human Immunodeficiency Virus (HIV), however, few studies have been directed at patients under 18 years old. In this context, the aim of this study is to estimate the prevalence of allergic disease in patients under 18 years old, living with HIV, and to investigate the relationship between clinico-immunological characteristics of the HIV infection and atopy.MethodsThis is a cross-sectional epidemiological study involving patients under 18 years of age who were followed up by specialized HIV services in the Southern Region of the State of Santa Catarina, Brazil, from February to October 2012. Data collection tools included a questionnaire established by the International Study of Asthma and Allergy in Childhood (ISAAC), socio-demographic data, as well as laboratory test results obtained from the medical records. Blood samples were taken to measure total serum Immunoglobulin E (IgE) levels and a Radioallergosorbent Test (RAST) for the main aeroallergens. Analysis was performed using Student’s t test, chi-squared, Fisher’s exact and Mann–Whitney tests, wherever indicated, with p < 0.05 value considered significant.Results29 individuals were evaluated. The prevalence of symptoms of allergic disease was 65.5% (95% CI 56.1-74.8), the most frequent being rhinitis 44.8% (95% CI 35.0-54.5), followed by asthma 37.9% (95% CI 28.3-47.4) and eczema 27.6% (95% CI 18.8-36.3). RAST was positive in 20.7% of the individuals. There was no significant difference in terms of total serum IgE between individuals with and without symptoms of allergic disease. Nevertheless, a high frequency of raised levels of total serum IgE (40.7%) and an association between raised IgE and clinical staging of disease were observed. A further association between CD8+ cell count and prevalence of symptomatic allergic disease (p = 0.014) was observed.ConclusionThere was a high prevalence of reported allergic disease, as well as a high frequency of raised levels of total serum IgE. The association between CD8+ cell count and the prevalence of symptomatic allergic disease corroborates studies that demonstrated the role of such cells in the development of allergic disease.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Allergic diseases in subjects under 18 years living with HIV

Linhar

Traebert

Galato

et al. 2014

All Asth Clin Immun

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“…Various hypotheses had been postulated by previous researchers and they included antigenic challenges from infectious agents such as viruses and parasites. [20][21][22][23] It has also been documented that abnormal activation of B-cells in HIVinfected individuals leads to spontaneous proliferation and secretion of all immunoglobulins (hypergammaglobulinemia) with the gradient of increase being more with IgE than the other immunoglobulins.…”

Section: Discussionmentioning

confidence: 99%

Serum Immunoglobulin E levels and Atopic Diseases in Human Immunodeficiency Virus-Infected and Non-Infected Children and Their Association with the Severity of HIV Infection at a Tertiary Hospital, South-West Nigeria

Olagunju

Oninla

Oyedeji

2022

Int J Health Sci Res

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Human immunodeficiency virus (HIV) infection had been reported to increase serum Immunoglobulin E (IgE) and the prevalence of atopic diseases. However, there is a paucity of data in the literature on the association between the severity of HIV infection and serum IgE and atopic diseases among children in the Sub-Sahara African region, particularly Nigeria. OBJECTIVES: To assess serum IgE levels, prevalence and pattern of atopic diseases, and their association with the severity of HIV infection in children on antiretroviral therapy. METHODS: One hundred HIV-infected children on antiretroviral therapy recruited consecutively into a cross-sectional study were age and sex-matched with 100 non-infected. International study of asthma and allergy in childhood (ISAAC) proforma was used to obtain information from all the participants. Serum IgE levels and Cluster of differentiation (CD) 4+ counts of all the participants were determined, as well as, HIV viral load of the infected participants. HIV viral load, CD 4 counts and WHO clinical staging were used to classified HIV severity. Data analysis was done using statistical package for social sciences (SPSS) version 21, and statistic significant level was put at p<0.05. RESULTS: Mean (SD) serum IgE of the HIV-infected and non HIV-infected children were 150.6 (12.7)iμ/ml and 94.8 (5.6)iμ/ml respectively (p=0.001). The overall prevalence of atopic diseases among HIV-infected and non-infected children were 15.0% and 6.0% respectively, p=0.031. Among HIV-infected, allergic conjunctivitis accounted for 11.0% and allergic rhinitis 4.0%, while among non-infected allergic conjunctivitis, atopic dermatitis and asthma accounted for 4.0%, 1.0% and 1.0% respectively. Based on WHO clinical staging, serum IgE level was significantly higher in advanced disease than in early (p<0.001), and likewise the prevalence of atopic diseases (p=0.011).Funso Abidemi Olagunju et.al. Serum immunoglobulin E levels and atopic diseases in human immunodeficiency virus-infected and non-infected children and their association with the severity of HIV infection at a tertiary hospital, south-west Nigeria

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Acquired Immune Deficiency Syndrome in Differential Diagnosis of Hyper-IgE-Immunoglobulinemia: Pediatric Case Report

et al. 2016

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Acquired immune deficiency syndrome can be encountered with hypereosinophilia and hyperimmunoglobulin E (hyper-IgE) values, though these levels are rarely so high to be compared with hyperimmunoglobulin E syndrome. A 9-year-old boy presented with the complaint of fatigue, weakness, weight loss and generalized pruritic rash lasting for a year. He had frequent respiratory tract infections, wheezing episodes and urticarial skin lesions before that. On admission, he was cachectic and he had generalized lymphadenopathy, hepatosplenomegaly, oral moniliasis and pruritic rash all over his body. Laboratory evaluation revealed marked lymphopenia and hypergammaglobulinemia with extremely high IgE values (IgE: 59 300 kU/l). He was diagnosed with stage 4 human immunodeficiency virus (HIV) infection and started on antiretroviral treatment. In conclusion, HIV infection can be presented with increased IgE values.

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Laboratorial atopy markers in children with human immunodeficiency virus

Cited by 3 publications

References 27 publications

Allergic diseases in subjects under 18 years living with HIV

Allergic diseases in subjects under 18 years living with HIV

Serum Immunoglobulin E levels and Atopic Diseases in Human Immunodeficiency Virus-Infected and Non-Infected Children and Their Association with the Severity of HIV Infection at a Tertiary Hospital, South-West Nigeria

Acquired Immune Deficiency Syndrome in Differential Diagnosis of Hyper-IgE-Immunoglobulinemia: Pediatric Case Report

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