IgA‐Associated Glomerulonephritis

Woodroffe, Andrew J.; Thomson, Napier M.; Meadows, R.; Lawrence, J. R.

doi:10.1111/j.1445-5994.1975.tb03635.x

Cited by 18 publications

(5 citation statements)

References 4 publications

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“…More fulminant mucosal antigenic exposure with penetration of antigen into the extracellular fluid could lead to an associated IgG or IgM antibody response, which would favor C3 deposition. This idea is further supported by the observations of some authors that codeposition of IgG and/or IgM in humans correlates with a more severe disease (4)(5)(6)(7)12). Finally, species differences in the capacity of pure IgA immune complexes to promote full complement fixation may exist between mice and men.…”

Section: Discussionsupporting

confidence: 60%

Experimental IgA nephropathy induced by oral immunization.

Emancipator¹,

Gallo²,

Lamm³

1983

The Journal of Experimental Medicine

160

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To test the hypothesis that IgA nephropathy can result from a mucosal immune response, mice were orally immunized with one of three protein antigens for 14 wk. Such mice exhibited an essentially pure mucosal antibody response characterized by specific IgA-producing plasma cells in exocrine sites and specific IgA antibodies in serum. Furthermore, 73% of immunized mice had IgA and 88% had immunogen deposited in the glomerular mesangium, and 64% of immunized mice examined ultrastructurally had electron-dense mesangial deposits. All three were present concurrently in 57% of the immunized mice. No differences in regard to IgG or IgM were observed between immunized and control mice for any of these parameters. Mucosal immunization therefore can result in a specific immune response that leads to mesangial deposition of immune complexes containing IgA antibody. In its fundamental features the experimental renal lesion resembles that seen in the human disease IgA nephropathy.

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Section: Discussionsupporting

confidence: 60%

Experimental IgA nephropathy induced by oral immunization.

Emancipator¹,

Gallo²,

Lamm³

1983

The Journal of Experimental Medicine

160

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show abstract

“…Since IgA is the only con stant immunoglobulin, the term IgA mesangial nephrop athy is now preferred. An IgA-IgG combination was found in approximately 50% of the cases [10,22,24,25], IgA alone was found in 45.7% of 239 cases, accompanied by IgG in 50.1 %, IgM in 21.4%, C3 in 82.4%, and fibrin ogen in 37.2% of the patients [10]. Most workers have failed to find IgA secretory component (SC) in the glo merular mesangium [10,17,19,26,27].…”

Section: Immunopathology Of Iga Nephropathymentioning

confidence: 99%

IgA Mesangial Nephropathy: Bergers Disease

Sinniah¹

1985

Am J Nephrol

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“…Occasionally it may be the only immunoglobulin present (Berger, 1969;Hyman et al, 1973;Lowance et al, 1973;Roy et al, 1973;McCoy et al, 1974;Morel-Maroger and Verroust, 1975;Woodroffe et al, 1975;Zimmerman and Burkholder, 1975). We therefore reviewed our renal biopsy material and studied further those cases in which there were significant glomerular IgA deposits.…”

mentioning

confidence: 99%

IgA localisation in glomerular diseases.

Lawler¹,

Williams²,

Tarpey³

et al. 1977

J Clin Pathol

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SUMMARY The structural changes found on light and electron microscopy study of 25 renal biopsy specimens that showed significant glomerular IgA deposition on immunofluorescence were correlated with relevant clinical data. The morphology of a wide range of glomerulopathies seen included mesangial proliferative (60%), membranous (12%), rapidly progressive proliferative (8%), mesangiocapillary (8%), and no light microscope change (8%). Four of the 15 cases (60%) of mesangial proliferative glomerulonephritis were associated with focal segmental sclerosis and 10 with focal segmental and focal global sclerosis. In addition, 7 of the 15 cases showed capsular crescents. The clinicopathological correlations indicated that the prognosis in this group is unfavourable when focal global sclerosis and capsular crescents are present, particularly when both occur in the same biopsy specimen.

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IgA‐Associated Glomerulonephritis

Cited by 18 publications

References 4 publications

Experimental IgA nephropathy induced by oral immunization.

Experimental IgA nephropathy induced by oral immunization.

IgA Mesangial Nephropathy: Bergers Disease

IgA localisation in glomerular diseases.

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