IgA Mesangial Nephropathy: Bergers Disease

Sinniah, Raja

doi:10.1159/000166911

Cited by 45 publications

(17 citation statements)

References 35 publications

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“…This immunologic response has been reported in only 1 other case in the literature on primary APS [41]. It is now well established that IgA nephropathy is the commonest glomerular lesion seen wordwide, with a high incidence in Singapore, with common presentation of hematuria and/or proteinuria [42][43][44] and also present in a latent state [45]. The renal morphology is variable, and the lesions range from minor mesangial changes to a diffuse proliferative glomerulonephritis with crescent formation and the later lesions progressing from focal segmental to global sclerosis [46].…”

Section: Discussionmentioning

confidence: 97%

“…It appears that in our patient the APS occurred with mesangial IgA nephropathy, which had a potentiating effect in the expression of the glomerulonephritis, leading to acute renal failure. The group of clinical syndromes associated with mesangial IgA deposits includes Henoch-Schönlein syndrome [44,48,49], liver cirrhosis [52,53], mucinous cancers [54], ankylosing spondylitis [55], and scleritis [56].…”

Section: Discussionmentioning

confidence: 99%

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Primary Antiphospholipid Antibody Syndrome and Mesangial IgA Glomerulonephritis

2001

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The antiphospholipid antibody syndrome (APS) is characterized by recurrent thrombosis, fetal loss, multiorgan involvement, and the presence of lupus anticoagulant and/or anticardiolipin antibody. When not associated with systemic lupus erythematosus, other collagen diseases, or ingestion of medications, the condition is called primary APS. The kidney may be involved in the APS syndrome with acute nephritis and renal failure. The cases with renal biopsy studies have shown variable glomerular morphology, ranging from mild mesangial changes to a diffuse endocapillary proliferative glomerulonephritis. The most frequent lesion is thrombotic microangiopathy or features seen in the hemolytic uremic syndrome. Apart from fibrin thrombus deposition, only a few cases have shown focal and segmental deposits of IgG and/or IgM and/or C3. We describe a patient with primary APS who had thrombosis with lower limb amputation and acute renal failure. The renal biopsy specimen showed a focal proliferative glomerulonephritis with endothelial proliferation and damage, with diffuse heavy mesangial deposits of IgA and fibrinogen. This case with diabetes mellitus, but without diabetic nephropathy, represents the occurrence of primary APS and mesangial IgA nephropathy which potentiated the renal injury, leading to acute renal failure. The relationship to the Henoch-Schönlein syndrome is discussed.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Primary Antiphospholipid Antibody Syndrome and Mesangial IgA Glomerulonephritis

2001

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“…7-9. 18], and certain HLA antigens [21]. Histo logic criteria claimed to reflect poor prognosis are: extra capillary proliferation [2,7,8], glomerular sclerosis and/or interstitial fibrosis [2.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic IgA Nephropathy Presenting as Malignant Hypertension

et al. 1986

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Three cases are reported of idiopathic IgA nephropathy (Berger’s disease) presenting as malignant hypertension, with no data suggesting the underlying glomerulopathy, which was uncovered only after renal biopsy was performed. Comments are made on the validity of the pathological diagnosis, the possible pathogenetic sequence of the association, and on the eventual risks and benefits derived from performing renal biopsy in such patients.

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“…Creatinine levels, creatinine clearance rate, and magnitude of proteinuria based on 24-h urine collections at the time of diagnostic renal biopsy were available for the majority of subjects. Biopsy specimens were processed for routine microscopic analyses for the diagnosis of IgAN, including hematoxylin and eosin, periodic acidSchiff, and Masson trichrome-silver impregnation staining, as well as electron microscopic analysis and immunofluorescence analysis (IgA, IgG, IgM, C3, C4, C1q, and fibrinogen) (9,10).…”

Section: Patientsmentioning

confidence: 99%

Downregulation of Bcl-2 by Podocytes Is Associated with Progressive Glomerular Injury and Clinical Indices of Poor Renal Prognosis in Human IgA Nephropathy

Qiu¹,

Sinniah

Hsu

2004

Journal of the American Society of Nephrology

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Abstract. Bcl-2 defines a new class of proto-oncogenes that block cell death without promoting cell proliferation. To elucidate the role of Bcl-2 in the development of glomerular lesions in human IgA nephropathy (IgAN), we applied immunohistochemistry coupled with in situ hybridization to detect the expression of Bcl-2 products and their association with Bax, p27 kip1 , and p57 kip2 in modulating the apoptotic, proliferative, and sclerotic events in progressive glomerular injury. Glomerular cell apoptosis was examined by TdT-mediated dUTP-biotin nick-end labeling (TUNEL) staining. A total of 51 IgAN cases were categorized into four subgroups (A to D) according to the severity of their histopathological lesions. Creatinine levels, creatinine clearance, and magnitude of proteinuria based on 24-h urine collections at the time of diagnostic renal biopsy were available for the majority of subjects.

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IgA Mesangial Nephropathy: Bergers Disease

Cited by 45 publications

References 35 publications

Primary Antiphospholipid Antibody Syndrome and Mesangial IgA Glomerulonephritis

Primary Antiphospholipid Antibody Syndrome and Mesangial IgA Glomerulonephritis

Idiopathic IgA Nephropathy Presenting as Malignant Hypertension

Downregulation of Bcl-2 by Podocytes Is Associated with Progressive Glomerular Injury and Clinical Indices of Poor Renal Prognosis in Human IgA Nephropathy

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