IgA localisation in glomerular diseases.

Lawler, W; Williams, George E.; Tarpey, Patrick; Acheson, Elise; Mallick, N P

doi:10.1136/jcp.30.10.914

Cited by 20 publications

(13 citation statements)

References 19 publications

(20 reference statements)

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“…Mild pro teinuria and normal renal function were usually present in most cases. These findings were confirmed by other authors in widely divergent geographic locations [2][3][4].…”

Section: Introductionsupporting

confidence: 82%

Strong Association of HLA-DR4 with Benign IgA Nephropathy

Hiki¹,

Kobayashi²,

Tateno³

et al. 1982

Nephron

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103 adult patients with biopsy-proved IgA nephropathy were typed for HLA-A and HLA-B antigens and 80 of these cases were typed for HLA-DR antigens. A significant association with HLA-DR4 was clearly noted (pc < 0.04). The high phenotype frequency (PF) of BW35 was observed in the patients, but not statistically significant (pc < 0.2). Two groups, the stable group and progressive group, were selected from all patients according to their clinical courses. The PF of HLA-DR4 was significantly higher in the stable group than the progressive group (pc = 0.005). The PF of BW35 was also higher in the stable group, but this difference was not statistically significant (pc = 0.6). The frequency of the combination of HLA-BW35 and DR4 increased significantly as compared to that in the control group. Further, the patients who had both of these antigens showed favorable courses. These results suggest that the HLA-DR4 antigen, especially a combination of HLA-BW35 and DR4 antigens are related to the occurrence of benign IgA nephropathy.

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“…Mild pro teinuria and normal renal function were usually present in most cases. These findings were confirmed by other authors in widely divergent geographic locations [2][3][4].…”

Section: Introductionsupporting

confidence: 82%

Strong Association of HLA-DR4 with Benign IgA Nephropathy

Hiki¹,

Kobayashi²,

Tateno³

et al. 1982

Nephron

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“…In all 23 cases, there was variable, diffuse, and global mesangial proliferation (Figs 1 and 2 Ultrastructurally, mesangial proliferation is con- firmed, but well defined intramesangial discrete granular electron dense deposits were identified in only half the cases, despite diffuse and global mesangial deposition of IgM. In many of these, and in most of the remainder however, there were ill defined, less granular electron dense areas which merged with the mesangial matrix.…”

Section: Light Microscopymentioning

confidence: 94%

“…Immunofluorescence findings include a range of combinations of IgG, IgM, complement fractions, and fibrinogen ;3 51516 in many cases, IgA predominates, an association usually considered separately and designated IgA nephropathy. [17][18][19][20][21][22][23] Recently, a primary mesangial proliferative glomerulonephritis with JgM predominating on immunofluorescence has been described and considered as a distinct clinicoimmunopathological entity. 24 25 In this account we have assessed its frequency and significance in biopsy material.…”

mentioning

confidence: 99%

IgM associated primary diffuse mesangial proliferative glomerulonephritis.

Lawler¹,

Williams²,

Tarpey³

et al. 1980

J Clin Pathol

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Twenty-three cases of IgM associated primary diffuse mesangial proliferative glomerulonephritis are presented. In 18, IgM was the sole localising host immunoglobulin, and it was the predominant globulin in five; C3 was also present in 18. Light microscopy revealed variable diffuse and global mesangial proliferation in all cases, with additional focal global sclerosis in 16, focal segmental sclerosis in 15, and small capsular crescents in seven. Material for electron microscopy was available from 19 patients; in 13, occasional intramesangial electron dense deposits were identified, and in 18 there were irregular, rather ill defined areas of increased electron density in mesangial regions. Clinically, 14 patients presented with the nephrotic syndrome, and nine had asymptomatic proteinuria. During follow-up, only 10 patients showed no change in renal function or improved; the remainder showed increasing hypertension and/or renal function deterioration and four developed end stage renal failure. It is suggested that IgM associated mesangial proliferative glomerulonephritis should be considered as a distinct clinicoimmunopathological entity.

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“…This nephropathy was considered as a be nign disorder, especially in earlier reports about the disease [1,3,8,[15][16][17][18][19][20]. Recently, however, a slowly progressive course to renal failure has occasionally been described [9,10,[21][22][23][24][25], and some clinical and histological parameters, such as hypertension, marked proteinuria or glomerular and tubulointerstitial sclerotic lesions have been recognized as being of value in predicting an unfavorable outcome. Yet it seems difficult to draw a definite conclusion in terms of prognostic indices because in the majority of the previous reports, the number of patients investigated was too small for a valid evaluation.…”

Section: Introductionmentioning

confidence: 99%

IgA Nephropathy: Prognostic Significance of Proteinuria and Histological Alterations

Kobayashi

Tateno

Hiki

et al. 1983

Nephron

137

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A retrospective study of 166 patients with IgA nephropathy was undertaken to clarify possible correlations between clinical and histological features, and the severity and prognosis of the disease. At the time of biopsy, impaired renal function, with creatinine clearance (C_cr) below 90 ml/min was found in 61 cases. At the final examination, after a mean follow-up period of 34 months, 82 patients had impaired renal function, 12 of these patients went into terminal renal failure requiring hemodialysis treatment. The presence of proteinuria of more than 1.0 g/day was closely correlated with impairment of renal function both at the time of biopsy and at the final observation. An unfavorable outcome was also anticipated in the presence of hypertension. In contrast, microhematuria, macrohematuria or high serum IgA levels did not appear to be related to the outcome. Histologically, sclerotic lesions such as mesangial or global sclerosis, interstitial fibrosis and tubular atrophy, and some active changes such as mesangial hypercellularity and tuft adhesion were more frequent and severe in patients with impaired renal function. Impressive localization of IgA and C3 in the mesangium as well as in capillary loops was observed more often in these patients. These results clearly indicate that IgA nephropathy may follow a slowly progressive course in about half of the patients, and that marked proteinuria and severe histological changes appear to correlate closely with an unfavorable course.

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IgA localisation in glomerular diseases.

Cited by 20 publications

References 19 publications

Strong Association of HLA-DR4 with Benign IgA Nephropathy

Strong Association of HLA-DR4 with Benign IgA Nephropathy

IgM associated primary diffuse mesangial proliferative glomerulonephritis.

IgA Nephropathy: Prognostic Significance of Proteinuria and Histological Alterations

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