IFN Stimulates ACE2 Expression in Pediatric Airway Epithelial Cells

Salka, K.; Abutaleb, Karima; Chorvinsky, E.; Thiruvengadam, Girija; Arroyo, Maria; Gutiérrez, María J.; Pillai, Dinesh K.; Jaiswal, Jyoti K.; Niño, Gustavo

doi:10.1165/rcmb.2020-0352le

Cited by 13 publications

(12 citation statements)

References 15 publications

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“…Likewise, IFN-γ was noted to promote cellular differentiation into enterocytes expressing ACE2, supporting the high viral infection and replication ( Heuberger et al, 2021 ). In another study, exposure to IFN-γ and IFN-λ caused a robust increment in the production of ISGs and ACE2 protein in nasal AE cells of infants ( Salka et al, 2021 ). Meanwhile, internalization of virus-ACE2 complex and ACE2 degradation, resulting in the reduction of membranal ACE2 protein ( Heyman et al, 2021 ).…”

Section: Role Of Ace2 In Sars-cov-2 Infectionmentioning

confidence: 95%

Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage

Kirtipal

Kumar

Dubey³

et al. 2022

Infection, Genetics and Evolution

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Section: Role Of Ace2 In Sars-cov-2 Infectionmentioning

confidence: 95%

Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage

Kirtipal

Kumar

Dubey³

et al. 2022

Infection, Genetics and Evolution

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“…Another potential trigger of excessive ROS production following COVID-19 is the deficiency of functional ACE2 after SARS-CoV-2 infection [ [99] , [100] , [101] ]. Although some evidences showed that ACE2 was up-regulated by IFN signaling in COVID-19 [ 45 , 102 ], it has recently been shown that the IFN-stimulated ACE2 was actually a truncated isoform with no function [ 103 , 104 ]. Thus, rather than being increased, the expression level of functional ACE2 could be reduced along with internalization of the SARS-CoV-2/ACE2 complex in COVID-19 [ [99] , [100] , [101] ].…”

Section: Signaling Pathways Possibly Involved In Covid-19 Associated Endothelial Dysfunctionmentioning

confidence: 99%

Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications

Ma¹,

Yang²,

Huang³

et al. 2022

Journal of Molecular and Cellular Cardiology

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“…However, gene set overlap may still remain strong. For example, utilizing one of these solutions, we enter a list of genes upregulated in nasal epithelial cells on ifn-lambda treatment 28 . Selecting a redundancy reduction feature, the first and second ranked outputs, involving the response to type I interferon and the response to gamma interferon, still contain 16 genes in common.…”

Section: Resultsmentioning

confidence: 99%

WhatIsMyGene: Back to the Basics of Gene Enrichment

Hodge,

Saethang

2023

Preprint

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WIMG AbstractSince its inception over 20 years ago, gene enrichment has been largely associated with curated gene lists (e.g. GO) that are constructed to represent various biological concepts; the cell cycle, cancer drivers, protein-protein interactions, etc. Researchers expect that a comparison of their own lab-generated lists with curated lists should produce insight. Despite the abundance of such curated lists, we here show that they rarely outperform existing individual lab-generated datasets when measured using standard statistical tests of study/study overlap. This demonstration is enabled by the WhatIsMyGene database, which we believe to be the single largest compendium of transcriptomic and micro-RNA perturbation data. The database also houses voluminous proteomic, cell type clustering, lncRNA, epitranscriptomic (etc.) data. In the case of enrichment tools that do incorporate specific lab studies in underlying databases, WIMG generally outperforms in the simple task of reflecting back to the user known aspects of the input set (cell type, the type of perturbation, species, etc.), enhancing confidence that unknown aspects of the input may also be revealed in the output. A limited number of GO lists are included in the database. However, these lists are assigned backgrounds, meaning that GO lists that are replete with abundant entities do not inordinately percolate to the highest ranking positions in output. We delineate a number of other features that should make WIMG indispensable in answering essential questions such as “What processes are embodied in my gene list?” and “What does my gene do?”

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IFN Stimulates ACE2 Expression in Pediatric Airway Epithelial Cells

Cited by 13 publications

References 15 publications

Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage

Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage

Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications

WhatIsMyGene: Back to the Basics of Gene Enrichment

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