Idiopathic hypertrophic subaortic stenosis

Braunwald, Eugene; Morrow, Andrew G.; Cornell, William P.; Aygen, M; Hilbish, Theodore F.

doi:10.1016/0002-9343(60)90074-7

Cited by 317 publications

(10 citation statements)

References 18 publications

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“…In 1960 this disorder was named obstructive cardiomyopathy (Goodwin et al, 1960) and subsequently hypertrophic obstructive cardiomyopathy (Cohen et al, 1964) and idiopathic hypertrophic sub aortic stenosis (Braunwald et al, 1960). In 1962, Wigle et al suggested the use of the term 'muscular subaortic stenosis' to describe this myocardial obstruction of a functional nature.…”

Section: Hypertrophic (Obstructive) Cardiomyopathymentioning

confidence: 99%

??-Adrenergic Receptor Blocking Drugs in Hypertrophic Cardiomyopathy, Autonomically Mediated Cardiovascular Functional Disorders and Fallot??s Tetralogy

Furberg

1974

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Section: Hypertrophic (Obstructive) Cardiomyopathymentioning

confidence: 99%

??-Adrenergic Receptor Blocking Drugs in Hypertrophic Cardiomyopathy, Autonomically Mediated Cardiovascular Functional Disorders and Fallot??s Tetralogy

Furberg

1974

Drugs

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“…[6][7][8] In the past, the characterization of arterial pressure pulses in patients with these lesions has consisted of descriptions of the pulse contour, determination of the presence and position of the anacrotic and dicrotic notches, measurement of the duration of systole and of the systolic upstroke time, and estimation of the slope of the pressure rise. In patients with severe valvular aortic stenosis, there is often prolongation of the total duration of ejection and of the systolic upstroke time.…”

mentioning

confidence: 99%

Diagnostic Value of the First and Second Derivatives of the Arterial Pressure Pulse in Aortic Valve Disease and in Hypertrophic Subaortic Stenosis

et al. 1964

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The brachial arterial dp/dt was continuously computed by means of an electronic differentiating circuit in 117 patients and 23 normal subjects. The peak dp/dt averaged 1092±372 (S.D.) mm. Hg/sec. in 32 patients with idiopathic hypertrophic subaortic stenosis, 547±94 mm. Hg/sec. in six patients with discrete subvalvular subaortic stenosis, 811±185 mm. Hg/sec. in 23 normal subjects, 358±85 mm. Hg/sec. in 29 patients with valvular aortic stenosis, 724±212 mm. Hg/sec. in 25 patients with combined aortic stenosis and regurgitation, and 1736±530 mm. Hg/sec. in 24 patients with pure aortic regurgitation. It is suggested that the elevated peak dp/dt seen in patients with hypertrophic stenosis is due to the absence of obstruction to ejection early in systole. In contrast, patients with valvular and discrete subvalvular stenosis, who exhibit fixed obstruction to outflow throughout ventricular systole, had a peak dp/dt that tended to be lower than normal. Calculation of the second derivative (d 2 p/dt 2 ) of the arterial pressure pulse provided even better separation of the various groups of patients studied. The analyses of the dp/dt and of the d 2 p/dt 2 of the brachial artery pressure pulse afford a simple and reliable assessment of the nature and location of left ventricular outflow obstruction and are helpful in the differentiation of valvular aortic stenosis, combined stenosis and regurgitation, and pure aortic regurgitation.

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“…The third type of obstruction is due to a muscle mass that protrudes into the left ventricular outflow tract and causes a " functional " obstruction in systole (Brock, 1957b). This has also been described as pseudo-aortic stenosis (Berqu et al, 1958), asymmetrical hypertrophy of the left ventricle (Teare, 1958), obstruction myopathy (Goodwin et al, 1960), and hypertrophic subaortic stenosis (Braunwald et al, 1960); it may occur as a familial disease. In this type, resection of the obstructing mass is difficult, and it is probable that the condition may recur through regrowth of muscle.…”

Section: Subvalvar Stenosis Generalmentioning

confidence: 98%