Idiopathic Hypereosinophilic Syndrome in 3 Rottweilers

Sykes, Jane E.; Weiss, Douglas J.; Buoen, L. C.; Blauvelt, Melissa; Hayden, D. W.

doi:10.1892/0891-6640(2001)015<0162:ihsir>2.3.co;2

Cited by 19 publications

(29 citation statements)

References 12 publications

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“…In those reports, the alveolar architecture surrounding the granulomas remained intact and was histologically characterized by type II pneumocyte proliferation with eosinophilic infiltration. Some cases were characterized by eosinophilic infiltration of other organs, resembling hypereosinophilic syndrome . In contrast, the disease in dogs with EG described here generally was confined to intra‐airway accumulation of mass‐like material, more similar to what was described in a CT study of dogs with eosinophilic granulomatosis .…”

Section: Discussionsupporting

confidence: 67%

Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006‐2016)

Johnson

Hulsebosch

et al. 2019

Veterinary Internal Medicne

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Background Eosinophilic lung disease is a poorly understood inflammatory airway disease that results in substantial morbidity. Objective To describe clinical findings in dogs with eosinophilic lung disease defined on the basis of radiographic, bronchoscopic, and bronchoalveolar lavage fluid (BAL) analysis. Categories included eosinophilic bronchitis (EB), eosinophilic granuloma (EG), and eosinophilic bronchopneumopathy (EBP). Animals Seventy‐five client owned dogs. Methods Medical records were retrospectively reviewed for dogs with idiopathic BAL fluid eosinophilia. Information abstracted included duration and nature of clinical signs, bronchoscopic findings, and laboratory data. Thoracic radiographs were evaluated for the pattern of infiltrate, bronchiectasis, and lymphadenomegaly. Results Thoracic radiographs were normal or demonstrated a bronchial pattern in 31 dogs assigned a diagnosis of EB. Nine dogs had intraluminal mass lesions and were bronchoscopically diagnosed with EG. The remaining 35 dogs were categorized as having EBP based on radiographic changes, yellow green mucus in the airways, mucosal changes, and airway collapse. Age and duration of cough did not differ among groups. Dogs with EB were less likely to have bronchiectasis or peripheral eosinophilia, had lower total nucleated cell count in BAL fluid, and lower percentage of eosinophils in BAL fluid compared to dogs in the other 2 groups. In contrast to previous reports, prolonged survival (>55 months) was documented in dogs with EG. Conclusions and Clinical Importance Dogs with eosinophilic lung disease can be categorized based on imaging, bronchoscopic and BAL fluid cytologic findings. Further studies are needed to establish response to treatment in these groups.

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Section: Discussionsupporting

confidence: 67%

Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006‐2016)

Johnson

Hulsebosch

et al. 2019

Veterinary Internal Medicne

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“…Multisystemic eosinophilic epitheliotropic disease is also known as hypereosinophilic syndrome (HES), and has been described in several different species including humans (DeVriese et al 1997;Roufosse et al 2007), dogs (Sykes et al 2001), and cats (McEwen et al 1985;Wilson et al 1996). In human medicine, HES is defined by a persistent and marked blood eosinophilia (41.5 6 10 9 /L for at least six consecutive months) with signs of multiple organ involvement and without the presence of common inducers of eosinophilia such as parasitic infection or hypersensitivity disorders.…”

Section: Discussionmentioning

confidence: 99%

Equine multisystemic eosinophilic epitheliotropic disease: A case report and review of literature

Bosseler

Verryken

Bauwens

et al. 2013

New Zealand Veterinary Journal

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Multisystemic eosinophilic epitheliotropic disease is rare in horses, and usually chronic. In the current case the horse showed an apparently acute onset with high fever and rapid clinical deterioration. A diagnosis of MEED should be considered in horses presenting with weight loss and skin lesions with or without fever. A final diagnosis is based on histological results of biopsy specimens from affected organs.

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“…IHES, a well‐known condition in humans and cats, is rare in dogs. IHES is suspected in animals with persistent eosinophilia (>6 months); no immature eosinophils, karyotypic abnormalities, or high serum IgE concentration; and no evidence of an underlying cause 6. Among nonhemic tumors of the dog, hypereosinophilia has been associated with anaplastic mammary carcinoma,7 oral fibrosarcoma,4 and rectal adenomatous polyp 8.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic hypereosinophilia in a dog with intestinal T‐cell lymphoma

Marchetti¹,

Benetti²,

Citi³

et al. 2005

Veterinary Clinical Pathol

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A 9-year-old, intact male Doberman Pinscher was examined because of anorexia and weakness. Results of a CBC showed severe, microcytic, hypochromic anemia with mild eosinophilia (2944 cells/microL, reference interval 100-1250/microL) and thrombocytosis. Hypoferremia, hypoferritinemia, and a positive fecal occult blood test supported a diagnosis of iron deficiency anemia secondary to chronic intestinal hemorrhage. Abdominal ultrasound evaluation showed a thickened small intestinal loop, of which representative specimens were obtained during exploratory laparotomy. Histologically, the intestinal wall was infiltrated by a neoplastic population of large, round, lymphoid cells with vesicular chromatin, 1 or more prominent nucleoli, and a high number of mitotic figures. The cells were closely admixed with mature eosinophils, but were negative for metachromatic granules with toluidine blue. Immunohistochemically, tumor cells were positive for CD3, and negative for CD21, Pan B, and CD79a. A diagnosis of intestinal T-cell lymphoma was made. Chemotherapy was begun, with 30 mg/m;2 of doxorubicin administered intravenously every 3 weeks. Eosinophil concentration was 880/microL 2 weeks after surgery (on day 15 after presentation) but increased markedly to 62,914/microL on day 30, 62,400/microL on day 37, and 39,444/microL on day 58 after presentation. An association between hypereosinophilia and T-cell lymphoma is well established in human patients, in whom production of IL-5 by neoplastic T cells has been demonstrated. Hypereosinophilia has been reported only rarely with intestinal lymphoma in cats and horses, and with T-cell lymphoma in dogs.

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Idiopathic Hypereosinophilic Syndrome in 3 Rottweilers

Cited by 19 publications

References 12 publications

Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006‐2016)

Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006‐2016)

Equine multisystemic eosinophilic epitheliotropic disease: A case report and review of literature

Paraneoplastic hypereosinophilia in a dog with intestinal T‐cell lymphoma

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