Paraneoplastic hypereosinophilia in a dog with intestinal T‐cell lymphoma

Abstract

A 9-year-old, intact male Doberman Pinscher was examined because of anorexia and weakness. Results of a CBC showed severe, microcytic, hypochromic anemia with mild eosinophilia (2944 cells/microL, reference interval 100-1250/microL) and thrombocytosis. Hypoferremia, hypoferritinemia, and a positive fecal occult blood test supported a diagnosis of iron deficiency anemia secondary to chronic intestinal hemorrhage. Abdominal ultrasound evaluation showed a thickened small intestinal loop, of which representative specimens were obtained during exploratory laparotomy. Histologically, the intestinal wall was infiltrated by a neoplastic population of large, round, lymphoid cells with vesicular chromatin, 1 or more prominent nucleoli, and a high number of mitotic figures. The cells were closely admixed with mature eosinophils, but were negative for metachromatic granules with toluidine blue. Immunohistochemically, tumor cells were positive for CD3, and negative for CD21, Pan B, and CD79a. A diagnosis of intestinal T-cell lymphoma was made. Chemotherapy was begun, with 30 mg/m;2 of doxorubicin administered intravenously every 3 weeks. Eosinophil concentration was 880/microL 2 weeks after surgery (on day 15 after presentation) but increased markedly to 62,914/microL on day 30, 62,400/microL on day 37, and 39,444/microL on day 58 after presentation. An association between hypereosinophilia and T-cell lymphoma is well established in human patients, in whom production of IL-5 by neoplastic T cells has been demonstrated. Hypereosinophilia has been reported only rarely with intestinal lymphoma in cats and horses, and with T-cell lymphoma in dogs.

Manifestação de síndrome paraneoplásica em um cão com hemangiossarcoma cutâneo: relato de caso

“…Com relação as alterações leucocitárias, a eosinofilia possivelmente decorreu do mecanismo de ação promovido pelas substâncias liberadas pelas células tumorais entre elas TNF-α, IL-1, IL-6 e IL-5 que estimulam o aumento na produção de eosinófilos, que também foi observado por Marchetti et al (2005) Childress (2012) e Duda (2014) em animais com linfoma, mastocitoma e neoplasias mamárias. É importante também considerar que se trata de uma neoplasia cutânea, ou seja, há um processo de injúria tecidual em um tecido rico em mastócitos, os quais são quimiotáticos para eosinófilos, um fator que também pode desencadear o aumento dos eosinófilos (Thrall et al, 2006).…”

Reação Leucemóide Associada À Sarcoma Indiferenciado Em Intestino Delgado De Cão

“…et al paraneoplásica (OGILVIE, 1997). As principais alterações associadas à síndrome paraneoplásica são anorexia, caquexia, anemia ou eritrocitose, leucocitose, trombocitopenia, hiper ou hipocalcemia, osteopatia hipertrófica, febre de origem desconhecida, hipoglicemia, hiperhistaminemia e hipergamaglobulinemia (YOUNG, 1997;MARCHETTI et al, 2005).…”

Eosinophilia and Eosinophilic Infiltration into Splenic B-Cell High-Grade Lymphoma in a Dog

“…Hypereosinophilia and eosinophilic infiltration have been reported in dogs with intestinal T-cell lymphoma [8,11]. However, neither eosinophilia nor eosinophilic infiltration has been reported previously in dogs with B-cell lymphoma.…”

“…Thus far, neither eosinophilia nor infiltration of eosinophils has been reported in dogs with Bcell lymphoma, although both have been reported in dogs with T-cell intestinal lymphoma [8,11]. In human medicine, paraneoplastic eosinophilia is often observed in patients with lymphoma.…”