Identifying the Factors That Affect Depressive Symptoms in Middle-Aged Menopausal Women: A Nationwide Study in Korea

Kim, Kisook

doi:10.3390/ijerph17228505

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Biologically, sustained stress causes the change of 5-hydroxytryptamine and cortisol systems, which is similar to that observed in a subtype of depression ( Van Praag, 2004 ). A nationwide study of middle-aged menopausal women in Korea noticed that a high level of perceived stress is a factor to influence depressive symptoms ( Kim, 2020 ). Depressive symptoms are associated with subjective well-being.…”

Section: Introductionmentioning

confidence: 99%

Association between perceived life stress and subjective well-being among Chinese perimenopausal women: a moderated mediation analysis

Ren

et al. 2022

PeerJ

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Background The impact of perceived life stress on subjective well-being has been well-established; while few studies have explored the mediating and moderating mechanisms of the association between perceived life stress and subjective well-being among perimenopausal women. This study is aimed at exploring the mediating effect of depressive symptoms and the role of interests/hobbies as a moderator in the association between perceived life stress and subjective well-being among perimenopausal women. Methods The participants were 1,104 perimenopausal women at the age of 40 to 60, who were asked to complete a paper-based questionnaire. A single item was used to measure self-perceived life stress and interests/hobbies. The Zung Self-rating Depression Scale (SDS) and Subjective Well-being Scale for Chinese Citizens (SWBS-CC) were applied to assess both depressive symptoms and subjective well-being. Multiple linear regression analysis and the PROCESS macro were adopted to analyse not only the mediating effect of depressive symptoms but also the moderating role of interests/hobbies. Results Perceived life stress was negatively associated with subjective well-being (B = − 1.424, β = − 0.101, P < 0.001). The impact of perceived life stress on subjective well-being was partially mediated by depressive symptoms (mediation effect = −0.760, 95% confidence intervals (CI) [−1.129, −0.415]). In addition, the interaction term between depressive symptoms and interests/hobbies was significantly related to subjective well-being (β = − 0.060, P < 0.05), indicating moderating effect. Moderated mediation had a significant index (Index = −0.220, SE = 0.099, 95% CI [−0.460, −0.060]). Conclusions Perceived life stress was negatively related to subjective well-being. The impact of perceived life stress on subjective well-being was mediated by depressive symptoms. Besides, interests/hobbies moderated the indirect effect of depressive symptoms on the relationship between perceived life stress and subjective well-being.

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Section: Introductionmentioning

confidence: 99%

Association between perceived life stress and subjective well-being among Chinese perimenopausal women: a moderated mediation analysis

Ren

et al. 2022

PeerJ

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“…Other prominent psychological symptoms are mood swings, irritability, unstable emotions, feeling worthless, and the emergence of anxiety that can interfere with daily activities (Reid et al, 2014). Depression is the most common psychological disorder in perimenopausal women (Fouad et al, 2021;Kim, 2020;National Institute of Mental Health, 2010). Depression negatively affects postmenopausal women related to personality, relationships with friends, and performance at work (Barghandan et al, 2021;Fouad et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Menopausal women should take precautions against psychological problems such as depression (Bernard et al, 2015). It aims to improve their quality of life, especially in the psychological domain, and decrease morbidity (Kim, 2020). Several therapies to overcome depression in menopausal women have been carried out, such as estrogen hormone therapy, but this therapy has side effects.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Physical Exercise on Depression in Menopausal Women

Fitriana

Nasution

Darmawati

et al. 2021

J. pendidik. jasmani olahraga

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Mood disorders are a frequent complaint experienced by women during menopause due to hormonal changes. Physical exercise is known to reduce depression, but research on menopausal women is limited. The purpose of this study was to determine the effect of physical exercise on depression in menopausal women. The study design used was quasi-experimental with pre-test and post-test for 16 weeks. The measuring instrument used was a GDS (Geriatric Depression Scale). The research subjects consisted of 34 menopausal women aged 45-65 years. Subjects were divided into two groups, including the physical exercise group (2x90 minutes/week, n=17) and the control group (n=17). The results showed that physical exercise significantly decreased depression (p=0.013) in the physical exercise group compared to the control group. It concludes that regular exercise is effective for preventing and treating mood disorders that occur when menopause.

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May the SSRIs play a role in the onset of peri- and post-menopausal cervical cancer?

Gargiulo Isacco,

Del Prete,

Distratis

et al. 2024

Discov Appl Sci

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The emergence of cancer-causing bacteria and viruses that have become resistant to either antibiotics or viral treatment is often attributed to their overuse in people and livestock. Intriguingly, the class of antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRIs), may also contribute to generating resistant microorganisms with a profound disturbing role in local cervix-vagina homeostasis. Therefore, we proposed the possible involvement of SSRIs in the onset and growth of cervical cancer (CC), which is based on some empirical considerations, (i) the number of women diagnosed with post-menopausal CC is almost equivalent to the number of women diagnosed with depressive problems, (ii) the proven affection of SSRIs on both vaginal and intestinal microbiota, (iii) the essential role of the microbiota in the immune response against oncogenic pathogens, including human papillomavirus and Chlamydia trachomatis (C. trachomatis), (IV) the role of SSRIs in favoring the rise of antibiotic-resistant microorganisms, and (V) the inhibitory effect of SSRIs in the estradiol-serotonin-prolactin axis. These features are important in the overproduction of reactive oxygen species, responsible for different harmful activities such as higher cell membrane permeability and porosity, hyperstimulation of transcription, and translational activities, with overall stress on check-point genes involved in ATP synthesis, DNA breaks, and abnormal mutations. This paper's results suggested reconsidering the efficacy of SSRIs on long-term use since the overall increase in prescriptions is mainly due to long-term treatment rather than the diagnoses per se, secondly little is known about the consequences of long-term use. The evidence that supports the role of antidepressant drugs in increasing the risk of CC was searched and discussed.

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Identifying the Factors That Affect Depressive Symptoms in Middle-Aged Menopausal Women: A Nationwide Study in Korea

Cited by 3 publications

References 46 publications

Association between perceived life stress and subjective well-being among Chinese perimenopausal women: a moderated mediation analysis

Association between perceived life stress and subjective well-being among Chinese perimenopausal women: a moderated mediation analysis

The Effect of Physical Exercise on Depression in Menopausal Women

May the SSRIs play a role in the onset of peri- and post-menopausal cervical cancer?

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