This work provides a review of economic, technical, sociocultural, political, and technological barriers that impede carbon neutrality in the building sector of countries in the Global South. These barriers include limitations in public and professional awareness, knowledge, and skills in the construction industry, the lack of ambitious energy codes and green building rating systems, the lack of green financing schemes and investment, costs of materials and technology, and limitations in regulations. Finally, this article recommends five transformations to address the critical barriers and enable net-zero emission status in the building sector of countries in the Global South. These transformations include environmental data collection, stringent building energy codes, and green building system certifications, lifecycle-based thinking and circular design, education enhancement and workforce development, and net-zero emission business practices.