Identifying Differing Intracellular Cargo Release Mechanisms by Monitoring In Vitro Drug Delivery from MOFs in Real Time

Μαρκοπούλου, Παναγιώτα; Panagiotou, Nikolaos; Li, Aurelia; Bueno-Pérez, Rocío; Madden, David G.; Buchanan, Sarah; Fairen‐Jimenez, David; Shiels, Paul G.; Forgan, Ross S.

doi:10.1016/j.xcrp.2020.100254

Cited by 25 publications

(22 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimentally and computationally it was verified that doxorubicin can be pore loaded in MIL-101(Cr) and surface loaded on UiO-66, different time-dependent cytotoxicity profiles are observed by real-time cell analysis and confocal microscopy [35]. The attenuated release of aggregated doxorubicin from the surface of Dox@UiO-66 results in a 12 to 16 h induction of cytotoxicity, while rapid release of pore-dispersed doxorubicin from Dox@MIL-101(Cr) leads to significantly higher intranuclear localization and rapid cell death.…”

Section: Recent Researches On Drug Delivery In Mofsmentioning

confidence: 81%

Metal Organic Frameworks (MOFs) as efficient carrier for targeted nanodrug delivery

Karki

Adhikari

et al. 2020

Himalayan Physics

View full text Add to dashboard Cite

A controllable and targeted drug delivery system development is imperative and important to reduce side effects and enhance the therapeutic efficacy of drugs. Metal-organic frameworks (MOFs), an emerging type of hybrid porous materials synthesized from metal ions or clusters abridged by organic linkers. They have attracted increasing attention in the recent years owing to the unique physical structures possessed, and the potential for wide range of applications. The superior properties of MOFs, such as well-deﬁned pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, have made them promising candidates as drug delivery hosts. MOFs for drug encapsulation and delivery is of great interest and many very promising results have been found, indicating that these porous solids exhibit several advantages over existing systems. This review highlights the recent advances in the synthesis, functionalization, and applications of MOFs in nanodrug delivery, and has classiﬁed them using drug loading strategies.

show abstract

Section: Recent Researches On Drug Delivery In Mofsmentioning

confidence: 81%

Metal Organic Frameworks (MOFs) as efficient carrier for targeted nanodrug delivery

Karki

Adhikari

et al. 2020

Himalayan Physics

View full text Add to dashboard Cite

show abstract

“…Using real‐time cell analysis, Markopoulou et al identified intracellular cargo release mechanisms differing from those of MOFs in vitro. [ 59 ] With extracellular acidification, lipid‐coated MIL‐100 containing iron and trimesic acid was reported to produce iron ions via the degradation of the MOF composites, leading to cancer cell death. [ 60 ] With a different design, zirconium MOF MIP‐202 (Zr) prepared with natural α‐natural amino acids displayed proton conduction features, excellent chemical stability, and a wide pH range.…”

Section: Single Stimulus Mofsmentioning

confidence: 99%

Advances in Functional Metal‐Organic Frameworks Based On‐Demand Drug Delivery Systems for Tumor Therapeutics

Yalamandala

Shen

Min

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Dual on‐demand delivery of therapeutic cargos and energy by transporters can latently mitigate side effects and provide the unique aspects required for precision medicine. To achieve this goal, metal‐organic frameworks (MOFs), hybrid materials constructed from metal ions and polydentate organic linkers, have attracted attention for controlled drug release and energy delivery in tumors. With appropriate characteristics such as tunable pore size, high surface area, and tailorable composition, therapeutic agents (drug molecules or responsive agents) can be effectively encapsulated in MOFs. Based on their intrinsic properties, many physically or chemically responsive agents are able to achieve precise on‐demand drug release and energy generation (thermal or dynamic therapy) using MOFs (as energy absorbers). Herein, the results obtained with various stimuli‐responsive MOFs (including materials from the Institute Lavoisier [MIL], zeolitic imidazolate frameworks [ZIFs], MOFs from the University of Oslo [UiO], and other MOFs) used for tumor suppression are summarized. Furthermore, with the appropriate stimulus, catalytic therapy (caused by the Fenton reaction induced by MOFs) can be provided via the utilization of existing high levels of H2O2 in cancer cells, which potentially elicits immune responses. In addition, the issues impeding clinical translation are also discussed, including the need to overcome tumor heterogeneity and to recognize the innate immune system and possible effects. As the references reveal, additional comprehensive strategies and studies are needed to enable broad applications and potent translational developments.

show abstract

“…The terminal connected water molecules of MIL-101(Cr) can be removed under high temperature or vacuum conditions, which creates potential Lewis acid sites [20]. Hence, MIL-101(Cr) demonstrates quite good water stability, which makes it suitable for wide applications, especially in the presence of moisture/water conditions, such as catalysis [21,22], adsorption [23,24], separation [25,26], drug delivery [27,28], gas storage [29,30], water pollution treatment [31], and mixed matrix membranes [32,33], among others.…”

Section: Introductionmentioning

confidence: 99%

Low-Temperature and Additive-Free Synthesis of Spherical MIL-101(Cr) with Enhanced Dye Adsorption Performance

et al. 2022

View full text Add to dashboard Cite

The chromium-benzenedicarboxylate metal–organic framework (MOF), MIL-101(Cr), is one of the most well-investigated and widely used prototypical MOFs. Regarding its synthesis, the use of a toxic modulator (usually HF) and high reaction temperature (220 °C) are the main factors hindering its further expansion of production and utilization. In fact, high quality MIL-101(Cr) crystals can be prepared at a much lower temperature (160 °C) with spherical morphology via an additive-free approach. Compared to traditional octahedral MIL-101(Cr), the spherical MIL-101(Cr) possesses higher adsorption performance toward dye molecules, including methyl orange (MO) and rhodamine B (RB). The results suggest that toxic additives and high reaction temperatures are not essential in the synthesis of MIL-101(Cr), and the fabrication of spherical MIL-101(Cr) may offer a facile and effective pathway for the large-scale industrial application of MIL-101(Cr).

show abstract

Identifying Differing Intracellular Cargo Release Mechanisms by Monitoring In Vitro Drug Delivery from MOFs in Real Time

Cited by 25 publications

References 78 publications

Metal Organic Frameworks (MOFs) as efficient carrier for targeted nanodrug delivery

Metal Organic Frameworks (MOFs) as efficient carrier for targeted nanodrug delivery

Advances in Functional Metal‐Organic Frameworks Based On‐Demand Drug Delivery Systems for Tumor Therapeutics

Low-Temperature and Additive-Free Synthesis of Spherical MIL-101(Cr) with Enhanced Dye Adsorption Performance

Contact Info

Product

Resources

About