Identification of novel anticancer terpenoids from &lt;i&gt;Prosopis juliflora&lt;/i&gt; (Sw) DC (Leguminosae) pods

Malik, Shazia Kanwal; Ahmed, Maqsood; Khan, Farah

doi:10.4314/tjpr.v17i4.14

Cited by 19 publications

(10 citation statements)

References 10 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some other studies also conveyed that the flavonoids and terpenoidsspectra typically consist of two absorption maxima in the ranges 230-285 nm (band I) and 300-350 nm (band II) which is in agreement with our results (Kalaichelvi and Dhivya, 2017;Renuka et al, 2016). Malik et al, (2018) revealedthat terpenoids were found at 372, 306, 248 nm with absorption 0.764, 0.912, 0.921 respectively (Malik et al,2018) which Figure 2: Fourier-Transform Infrared Spectroscopy analysis of total phytochemical (TPC), total alkaloid (TAL), total phenol (TPC), total saponin (TSA) and total terpenoid (TTE) of C.pepo seeds also showing likeness with our results (Table 1). Our outcome of phenol spectra are in agreement of many other researchers (Engidaet al, 2015;Song et al, 2015;Rojas, et al, 2016;Ebrahimia, et al, 2015) who found that phenolic acids, e.g., gallic acid, ferulic acid, p-coumaric acids, and vanillic acid, have absorbance maxima in the range of approximately 290-350 nm.…”

Section: Resultssupporting

confidence: 80%

Characterization of Phytochemicals Isolated From Cucurbita Pepo Seeds Using Uv–vis and Ftir Spectroscopy

Rawat¹,

Garg²

2021

PLANT ARCHIVES

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 80%

Characterization of Phytochemicals Isolated From Cucurbita Pepo Seeds Using Uv–vis and Ftir Spectroscopy

Rawat¹,

Garg²

2021

PLANT ARCHIVES

View full text Add to dashboard Cite

show abstract

“…FTIR spectral data indicated the reducing role of bioactive molecules present in MA-extract. Presence of terpenoids, flavonoids, and phenolic compounds was demonstrated by stretching vibration band at 2349 cm −1 (O=C=O) in Prosopis juliflora and 1457 cm −1 (CH) and 1640 cm −1 (C=C) in Propolis 34,35. Our FTIR data showed, the predominant peak of OH and C=C on the surface of the MA-AgNPs and implied presence of polyphenols.…”

Section: Discussionmentioning

confidence: 52%

<p>Biosynthesis of Silver Nanoparticles from <em>Melia azedarach</em>: Enhancement of Antibacterial, Wound Healing, Antidiabetic and Antioxidant Activities</p>

Gandhimathi

Chandrasekharan

Bhatnagar

2019

IJN

View full text Add to dashboard Cite

PurposeGlobal demand for novel, biocompatible, eco-friendly resources to fight diseases inspired this study. We investigated plants used in traditional medicine systems and utilized nanotechnology to synthesize, evaluate, and enhance potential applications in nanomedicine.MethodsAqueous leaf extract from Melia azedarach (MA) was utilized for bio-synthesis of silver nanoparticles (MA-AgNPs). Reaction conditions were optimized for high yield and colloidal stability was evaluated using UV-Vis spectroscopy. MA-AgNPs were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Standard methods were used to analyze the antibacterial, wound healing, antidiabetic, antioxidant, and cytotoxic activities.ResultsThe formation of MA-AgNPs at room temperature was confirmed by stable brown colloidal solution with maximum absorbance at 420 nm (UV-Vis Spectroscopy). MA-AgNPs were spherical (SEM), uniformly dispersed, 14–20 nm in diameter (TEM), and crystalline in nature (XRD). Presence of elemental silver was confirmed by peak at 3 KeV (EDX). FTIR data revealed the presence of functional groups which indicate phyto-constituents (polyphenols, flavonoids, and terpenoids) may have acted as the reducing and capping agents. MA-AgNPs (1000 µg/mL) showed larger zone of inhibition than MA-extract in the disk diffusion assay for human pathogenic gram positive bacteria, Bacillus cereus (34 mm) and gram negative, Escherichia coli (37 mm), thus confirming their higher antibacterial activity. The cell scratch assay on human dermal fibroblast cells revealed potential wound healing activity. The MA-AgNPs (400 µg/mL) demonstrated high antidiabetic efficacy as measured by α-amylase (85.75%) and α-glucosidase (80.33%) inhibition assays and antioxidant activity as analyzed by DPPH (63.83%) and ABTS (63.61%) radical scavenging assays. Toxic effect of MA-AgNPs against human chang liver cells (CCL-13) as determined by MTS assay, optical microscopic and CMFDA dye methods was insignificant.ConclusionThis sustainable, green synthesis of AgNPs is a competitive alternative to conventional methods and will play a significant role in biomedical applications of Melia azedarach.

show abstract

“…Quimicamente, os frutos P. juliflora possuem diversos ativos como terpenoides, fenol, saponina e taninos com atividade farmacológica descrita em literatura (IBRAHIN et al, 2013;RICÓN et al, 2014;PREETI et at., 2017;Henciya et al, 2017). Com comprovada ação anticancerígena, apresenta compostos como Pentanal (nasofaringe), Butiramida (nasofaringe), ácido n-hexadecanóico (pâncreas, faringe, próstata, mama, pulmão) Genoplasto B (mama, pulmão, bexiga e próstata) (Malik, Ahmed, & Khan, 2018).…”

Section: Resultsunclassified

Atividade antitumoral in vitro de Prosopis juliflora frente a células cancerígenas do tipo melanoma

Cavalcante

Barbosa

Silva

2021

RSD

View full text Add to dashboard Cite

O objetivo deste estudo foi investigar a atividade antitumoral de Prosopis juliflora contra células tumorais humanas da linhagem B16-F10 (melanoma) para buscar novos medicamentos derivados de fontes naturais. Testes in vitro foram conduzidos com os extratos brutos de folhas e de casca de caule frente às linhagens de células B16-F10 e linhagem de células J774 através do teste de citotoxicidade de MTT (3- (4,5-dimetiazol-2il) 2,5-difenil tetrazólio de brometo) com monitorização após 24 e 48 h de exposição das células tumorais e não tumorais a diferentes concentrações dos extratos (100; 50; 25; 12,5 μg/mL). O extrato de casca de caule e o extrato de folha de P. juliflora inibiram a proliferação de células B16-F10 a partir da menor concentração testada 12,5 Mg/ml e não apresentaram citotoxidade frente às células não tumorais. Entretanto, o extrato de folha de P. juliflora apresentou diminuição sobre a viabilidade celular de forma considerável a partir de 50 Mg/ml. Sugere-se o estudo químico para extração e isolamento de compostos ativos oriundo dos extratos de folha e da casca de caule de P. juliflora, para investigar a possível atividade antitumoral destes compostos em ensaio in vitro e in vivo.

show abstract

Identification of novel anticancer terpenoids from <i>Prosopis juliflora</i> (Sw) DC (Leguminosae) pods

Abstract: Purpose: To identify a novel source of terpenoid anticancer compounds from P. juliflora (Sw.)

Cited by 19 publications

References 10 publications

Characterization of Phytochemicals Isolated From Cucurbita Pepo Seeds Using Uv–vis and Ftir Spectroscopy

Characterization of Phytochemicals Isolated From Cucurbita Pepo Seeds Using Uv–vis and Ftir Spectroscopy

<p>Biosynthesis of Silver Nanoparticles from <em>Melia azedarach</em>: Enhancement of Antibacterial, Wound Healing, Antidiabetic and Antioxidant Activities</p>

Atividade antitumoral in vitro de Prosopis juliflora frente a células cancerígenas do tipo melanoma

Contact Info

Product

Resources

About