Identification of genes differentially expressed in human primary lung squamous cell carcinoma

Liu, Yan; Sun, Wenyue; Zhang, Kaitai; Zheng, Hongwei; Ma, Ying; Lin, Dongmei; Zhang, Xinyu; Li, Feng; Lei, Wendong; Zhang, Ziqiang; Guo, Shu; Han, Ning; Tong, Wei; Feng, Xiaoli; Gao, Yanning; Cheng, Shujun

doi:10.1016/j.lungcan.2007.01.016

Cited by 74 publications

(58 citation statements)

References 32 publications

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“…2 p value comparing cases and controls. 3 Chinese recommend standard was used for the cutoff points for overweight and obesity. Missing data were excluded from analysis for these variables that the total numbers of cases or controls were less than the total number.…”

Section: Discussionmentioning

confidence: 99%

“…2 Further adjusted for education level, previous income (continuous), BMI (continuous), pack-years of smoking (continuous), weekly ethanol intake (continuous) and number of siblings. 3 Add up exceeds the total number because some subjects have more than one type of family cancer history. 4 Subject without family history of cancer was used as a reference.…”

Section: Epidemiologymentioning

confidence: 99%

“…However, based on previous reports, more than 95% of esophageal cancers are expected to be of the type of ESCC in our analysis. 3 Fourth, although the questionnaire had been pretested in some previous studies and all interviewers had been trained to explain questions to subjects more clearly, the exposure level of most lifestyle risk factors was reported by study subjects without accurate measurements, and thus subjective judgment and recall bias (e.g., eating speed and temperatures of foods and drinks) may exist in this retrospective study and cause misclassification of exposures. Lastly, there is a large difference in the incidence of esophageal cancer between two study areas, which indicates the possible heterogeneity in the association of risk factors.…”

Section: Epidemiologymentioning

confidence: 99%

“…2 Squamous cell carcinoma of the esophagus remains the predominant histological subtype, representing more than 95% of total cases in the Chinese population. 3 The etiology of esophageal cancer shows that it is multifactorial. A number of studies have suggested that lifestyle factors are significant to the development of this disease.…”

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confidence: 99%

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Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? a population‐based case–control study in China

Zhang

Kampman

et al. 2011

Intl Journal of Cancer

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A population-based case-control study on esophageal cancer has been conducted since 2003 in Jiangsu Province, China. The aim of this analysis is to provide further evidence on the relationship between family history of cancer in first-degree relatives (FH-FDRs) and the risk of esophageal cancer, and to explore the joint effects for FH-FDR with major lifestyle risk factors. A total of 1,520 cases and 3,879 controls were recruited. Unconditional logistic regression was applied for evaluating independent association as well as potential interactions between FH-FDR and lifestyle risk factors on the risk of esophageal cancer. Population attributable fraction (PAF) was calculated to quantify the proportion of cases attributable to risk factors. Results showed that with a FH-FDR of any malignant tumor or esophageal cancer, there is a 1.64-and 2.22-fold risk of esophageal cancer, respectively. Association was increased when there was more than one affected FDR (OR 5 3.14) and younger age at diagnosis of relatives. Exposure of both FH-FDR and lifestyle risk factors strongly associated with esophageal cancer. Significant superadditivity interaction was found for FH-FDR with fast eating speed and diets low in fruits and vegetables. The estimation of PAF indicated that the majority of cases were attributed to lifestyle risk factors. In conclusion, it was found that FH-FDR significantly increases the risk of esophageal cancer and could modify the effect of certain lifestyle risk factors. If comprehensive lifestyle interventions are carried out within high-risk populations, there is a high probability of curbing occurrences of esophageal cancer.Esophageal cancer is one of the most common cancers worldwide, with $462,000 new cases and 386,000 deaths each year. China is an area with one of the highest incidences of esophageal cancer worldwide. Each year, about one-half of the cases of esophageal cancer that occur in the world are estimated to be in China. 1 According to the results of a national mortality retrospective survey conducted in 2006, esophageal cancer was the fourth leading cause of cancer death in China, with a national average age-standardized mortality of 15.2/100,000. 2 Squamous cell carcinoma of the esophagus remains the predominant histological subtype, representing more than 95% of total cases in the Chinese population. 3 The etiology of esophageal cancer shows that it is multifactorial. A number of studies have suggested that lifestyle factors are significant to the development of this disease. Tobacco smoking and alcohol consumption are responsible for a high fraction of esophageal cancer occurrence; more than 90% of cases could be attributed to these two factors in Western countries. 4 Dietary factors such as ingestion of hot foods and drinks, fast eating speed, nutrition deficiency and high intake of carcinogens from pickled vegetables have been suggested to contribute to most cases of esophageal cancer in high-risk areas such as China and Iran. 5,6 Moreover, genetics and other endogenous factors may also ...

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Section: Discussionmentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

mentioning

confidence: 99%

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Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? a population‐based case–control study in China

Zhang

Kampman

et al. 2011

Intl Journal of Cancer

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“…CLDND1/claudin domain containing 1 (Accession No. : NM_001040181) contains the domain of claudin which is involved in tight junction, but its function is not known [29]. CCNG2/cyclin G2 (Accession No.…”

Section: Discussionmentioning

confidence: 99%

Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies Detected in Patients with Systemic Lupus Erythematosus

Goto¹,

Sugiyama²,

Matsumura³

et al. 2015

J Mol Biomark Diagn

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RETRACTED: Physcion 8‐O‐β‐Glucopyranoside Exerts Anti‐Tumor Activity Against Non‐Small Cell Lung Cancer by Targeting PPARγ

Sun

et al. 2018

The Anatomical Record

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Lung cancer is one of the most common causes of cancer related mortality. The present study is designed to investigate whether a naturally occurring anthraquinone compound, physcion 8‐O‐β‐glucopyranoside (PG) could exert anti‐cancer activity against non‐small cell lung cancer (NSCLC). Cell viability was determined by Cell Counting Kit‐8 (CCK‐8) assay. Cell cycle distribution and cell apoptosis were determined by flow cytometry. Expressions of marker proteins were assessed by western blot analysis. To examine the role of PPARγ (peroxisome proliferator‐activated receptor γ) in PG‐induced apoptosis and cell cycle arrest, PPARγ was knockdown using siRNA. In addition, a xenograft model was established to investigate the effect of PG in vivo. The results showed that PG markedly induced cell cycle arrest and apoptosis in human NSCLC cell lines A549 and H358. The anti‐tumor effect of PG in NSCLC cells was mediated by upregulation of PPARγ. Besides, in NSCLC cell lines, the anti‐cancer activity of PG was also examined in the xenograft mice model, which showed that PG could significantly reduce tumor burden and activate apoptotic signaling. Our results demonstrated that PG can be regarded as a candidate chemotherapeutic agent for lung cancer. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc. Anat Rec, 302:785–793, 2019. © 2018 Wiley Periodicals, Inc.

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Identification of genes differentially expressed in human primary lung squamous cell carcinoma

Cited by 74 publications

References 32 publications

Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? a population‐based case–control study in China

Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? a population‐based case–control study in China

Identification of Cerebral Infarction-Specific Antibody Markers from Autoantibodies Detected in Patients with Systemic Lupus Erythematosus

RETRACTED: Physcion 8‐O‐β‐Glucopyranoside Exerts Anti‐Tumor Activity Against Non‐Small Cell Lung Cancer by Targeting PPARγ

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