Identification of Fusarium from a Patient with Fungemia after Multiple Organ Injury

Kang, Yuli; Li, Li; Zhu, Jiaan; Zhao, Ying; Zhang, Qiangqiang

doi:10.1007/s11046-013-9664-x

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Seven cases of fusarial pneumonia in immunocompetent patients were reported. 10,27,32,61,[119][120][121] In three cases, pneumonia was the only clinical manifestation of fusariosis, and in four cases it was part of disseminated disease. Underlying conditions were trauma, heat stroke, burn, alcohol abuse, chronic obstructive lung disease (one each), and none (1 case).…”

Section: Pneumonia In Immunocompetent Patientsmentioning

confidence: 96%

“…12,13 Indeed, Fusarium is the leading etiologic agent of fungal keratitis. In addition, various infections caused by Fusarium species in immunocompetent patients have been reported, including combat-related injuries, 14 peritonitis in patients receiving peritoneal dialysis, 15,16 thrombophlebitis, 17 arthritis, 18,19 osteomyelitis, [20][21][22][23] endophtalmitis, 24 fungemia, [25][26][27] sinusitis, [28][29][30][31] and pneumonia. [32][33][34] Fusariosis in immunocompromised patients is almost always an invasive and frequently disseminated disease.…”

Section: Clinical Spectrum Of Fusariosismentioning

confidence: 99%

“…The clinical spectrum of lung disease associated with Fusarium species is similar to that caused by Aspergillus species and includes allergic disease (allergic bronchopulmonary fusariosis), 59 hypersensitivity pneumonitis, 29 colonization of a pre-existing cavity, 60 localized pneumonia in immunocompetent individuals, 61 and pneumonia in severely immunocompromised patients. 3,8 We did a literature review of 294 cases of fusariosis, 3 and updated with 63 additional cases in immunocompetent 19,25,27,[61][62][63][64][65][66][67] and immunocompromised patients 31,34,39,43,44,47,48,50, published between 2005 and 2014. Pneumonia caused by Fusarium species was reported in 152 cases (42%), occurring in 145 of 317 (46%) immunocompromised patients and in seven of 40 (17.5%) immunocompetent patients (p < 0.001).…”

Section: Fusariosis In the Lungsmentioning

confidence: 99%

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Fusariosis

Nucci

Nouér

Capone

et al. 2015

Semin Respir Crit Care Med

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Fusarium species are frequent agents of onychomycosis and fungal keratitis, and occasional agents of invasive disease. The clinical spectrum of fusariosis in the lungs includes allergic disease (allergic bronchopulmonary fusariosis), hypersensitivity pneumonitis, colonization of a preexisting cavity, and pneumonia. Fusarial pneumonia occurs almost exclusively in severely immunocompromised patients, especially acute leukemia patients and recipients of allogeneic cell transplantation. In such patients, invasive fusariosis is usually disseminated, and pneumonia occurs in almost 50% of cases. The radiologic picture is similar to invasive aspergillosis, with alveolar infiltrates, nodules with or without halo sign, ground-glass infiltrates, and pleural effusions. Different from aspergillosis is the frequent occurrence of disseminated nodular and papular skin lesions and positive blood cultures. The drug of choice for the treatment of invasive fusariosis is either voriconazole or liposomal amphotericin B. The outcome is usually poor, and largely dependent on the recovery of the immune status of the host, particularly neutropenia.

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Section: Pneumonia In Immunocompetent Patientsmentioning

confidence: 96%

Section: Clinical Spectrum Of Fusariosismentioning

confidence: 99%

Section: Fusariosis In the Lungsmentioning

confidence: 99%

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Fusariosis

Nucci

Nouér

Capone

et al. 2015

Semin Respir Crit Care Med

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Fungaemia Caused by Fusarium proliferatum in a Patient Without Definite Immunodeficiency

et al. 2014

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Recent literature has shown the growing importance of opportunistic fungal infections due to Fusarium spp. However, disseminated fusariosis remains rare in patients without neutropenia. We report a case of fungaemia in a 78-year-old French woman without definite immunodeficiency. Fusarium proliferatum grew from both central and peripheral blood cultures. Fever was the only clinical sign of the infection. An appropriate antifungal therapy with voriconazole led to the recovery of the patient. An environmental investigation was undertaken but failed to find a reservoir of Fusarium spores. A contaminated central venous catheter might have been the source of fungaemia.

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Fatal Cases of Bloodstream Infection by Fusarium solani and Review of Published Literature

2015

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Fusarium species are ubiquitously present in environment and are well known as human pathogens with high mortality rate in immunocompromised patients. We report here two cases where immunocompromised patients developed fatal bloodstream infections by this organism. Isolates were further identified by ITS1 region sequencing which confirmed them as Fusarium solani. Antifungal susceptibility testing was done following CLSI M38-A2 guidelines to amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and micafungin. Both patients had a fatal outcome and expired of septic shock. Therefore, identification up to species level is of utmost importance as that helps in directing the management of the patient thereby leading to a favourable outcome.

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Identification of Fusarium from a Patient with Fungemia after Multiple Organ Injury

Cited by 5 publications

References 18 publications

Fusariosis

Fusariosis

Fungaemia Caused by Fusarium proliferatum in a Patient Without Definite Immunodeficiency

Fatal Cases of Bloodstream Infection by Fusarium solani and Review of Published Literature

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