Fungaemia Caused by Fusarium proliferatum in a Patient Without Definite Immunodeficiency

Dananché, Cédric; Cassier, Pierre; Sautour, Marc; Gautheron, Nadine; Wegrzyn, Julien; Perraud, M.; Bienvenu, Anne‐Lise; Nicolle, Marie-Christine; Boibieux, A.; Vanhems, Philippe

doi:10.1007/s11046-014-9817-6

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…In immunocompetent subjects, the most common manifestations of fusariosis include: localized keratitis, 321,340 onychomycosis, 322 skin involvement from trauma or burns, 144,341,342 and vascular involvement or peritonitis from foreign bodies (e.g., intravascular 343 or dialysis 344 catheters). Interestingly, cases of allergic bronchopulmonary mycosis 345 and mycetomas due to fusariosis have been described.…”

Section: Clinical Features Of Fusariosismentioning

confidence: 99%

“…346 Invasive disease or dissemination is exceptionally rare in immunocompetent hosts. 343,347 However, in patients with severe immune deficits, disseminated fusariosis can affect virtually any organ (e.g., lung, 331,335 sinuses, 348,349 bone, 350,351 joints, 352 endophthalmitis, 353 brain, 320 aorta, 354 and heart 339,[354][355][356] ). In disseminated fusariosis, lung involvement occurs in approximately 50%.…”

Section: Clinical Features Of Fusariosismentioning

confidence: 99%

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Fungal Infections Complicating Lung Transplantation

Clark

Weigt

Fishbein³

et al. 2018

Semin Respir Crit Care Med

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Lung transplantation is an increasingly utilized modality for treating advanced lung disease. However, lung transplant recipients (LTRs) experience high rates of infection-related mortality and, compared with other solid organ transplant recipients, are at increased risk of infectious complications given the intensity of immunosuppression employed, the presence of airway abnormalities after surgery and exposure of the allograft to the environment. Fungal infections, particularly mold infections, are problematic after transplantation as they are often associated with limited treatment options and poor outcomes. We describe the non- fungal infections occurring in LTRs, including their epidemiology, clinical features, and treatment.

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Section: Clinical Features Of Fusariosismentioning

confidence: 99%

Section: Clinical Features Of Fusariosismentioning

confidence: 99%

Fungal Infections Complicating Lung Transplantation

Clark

Weigt

Fishbein³

et al. 2018

Semin Respir Crit Care Med

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“…12,13 Indeed, Fusarium is the leading etiologic agent of fungal keratitis. In addition, various infections caused by Fusarium species in immunocompetent patients have been reported, including combat-related injuries, 14 peritonitis in patients receiving peritoneal dialysis, 15,16 thrombophlebitis, 17 arthritis, 18,19 osteomyelitis, [20][21][22][23] endophtalmitis, 24 fungemia, [25][26][27] sinusitis, [28][29][30][31] and pneumonia. [32][33][34] Fusariosis in immunocompromised patients is almost always an invasive and frequently disseminated disease.…”

Section: Clinical Spectrum Of Fusariosismentioning

confidence: 99%

“…The clinical spectrum of lung disease associated with Fusarium species is similar to that caused by Aspergillus species and includes allergic disease (allergic bronchopulmonary fusariosis), 59 hypersensitivity pneumonitis, 29 colonization of a pre-existing cavity, 60 localized pneumonia in immunocompetent individuals, 61 and pneumonia in severely immunocompromised patients. 3,8 We did a literature review of 294 cases of fusariosis, 3 and updated with 63 additional cases in immunocompetent 19,25,27,[61][62][63][64][65][66][67] and immunocompromised patients 31,34,39,43,44,47,48,50, published between 2005 and 2014. Pneumonia caused by Fusarium species was reported in 152 cases (42%), occurring in 145 of 317 (46%) immunocompromised patients and in seven of 40 (17.5%) immunocompetent patients (p < 0.001).…”

Section: Fusariosis In the Lungsmentioning

confidence: 99%

Fusariosis

Nucci

Nouér

Capone

et al. 2015

Semin Respir Crit Care Med

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Fusarium species are frequent agents of onychomycosis and fungal keratitis, and occasional agents of invasive disease. The clinical spectrum of fusariosis in the lungs includes allergic disease (allergic bronchopulmonary fusariosis), hypersensitivity pneumonitis, colonization of a preexisting cavity, and pneumonia. Fusarial pneumonia occurs almost exclusively in severely immunocompromised patients, especially acute leukemia patients and recipients of allogeneic cell transplantation. In such patients, invasive fusariosis is usually disseminated, and pneumonia occurs in almost 50% of cases. The radiologic picture is similar to invasive aspergillosis, with alveolar infiltrates, nodules with or without halo sign, ground-glass infiltrates, and pleural effusions. Different from aspergillosis is the frequent occurrence of disseminated nodular and papular skin lesions and positive blood cultures. The drug of choice for the treatment of invasive fusariosis is either voriconazole or liposomal amphotericin B. The outcome is usually poor, and largely dependent on the recovery of the immune status of the host, particularly neutropenia.

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“…Recently, other Fusarium spp. other than F. solani, such as F. oxysporum, F. verticilloides, F. petroliphilum, F. napiforme F. andiyazi and F. proliferatum have emerged as a cause of invasive fusariosis in patients with hematological malignancies or after organ transplantation [11][12][13][14][15]. Disseminated fusariosis is reported in patients with lymphoblastic leukemia [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Fusariosis in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature

et al. 2016

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Fusarium spp. causes infections mostly in patients with prolonged neutropenia. We describe the case of a disseminated Fusarium solani infection in a patient with acute myeloid leukemia which never reached complete remission during its clinical course. The patient had profound neutropenia and developed skin nodules and pneumonia in spite of posaconazole prophylaxis. F. solani was isolated from blood and skin biopsy, being identified from its morphology and by molecular methods. By broth dilution method, the strain was resistant to azoles, including voriconazole and posaconazole, and to echinocandins. MIC to amphotericin B was 4 mg/L. The patient initially seemed to benefit from therapy with voriconazole and amphotericin B, but, neutropenia perduring, his clinical condition deteriorated with fatal outcome. All efforts should be made to determine the correct diagnosis as soon as possible in a neutropenic patient and to treat this infection in a timely way, assuming pathogen susceptibility while tests of antimicrobial susceptibility are pending. A review of the most recent literature on invasive fungal infections is reported.

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Fungaemia Caused by Fusarium proliferatum in a Patient Without Definite Immunodeficiency

Cited by 13 publications

References 25 publications

Fungal Infections Complicating Lung Transplantation

Fungal Infections Complicating Lung Transplantation

Fusariosis

Fusariosis in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature

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