Identification of functional candidate genes for body composition by expression analyses and evidencing impact by association analysis and mapping

Ponsuksili, Siriluck; Muráni, Eduard; Schellander, K.; Schwerin, Manfred; Wimmers, Klaus

doi:10.1016/j.bbaexp.2005.06.004

Cited by 24 publications

(17 citation statements)

References 26 publications

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“…Indeed, expression level of PEDF in the liver is found to be high in humans and mice [16,17]. Further, expression level of PEDF in porcine liver is associated with body muscularity and obesity as well [18]. Production of PEDF by the liver may also be regulated by visceral adiposity.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of pigment epithelium‐derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes

Nakamura

Yamagishi

Adachi

et al. 2008

Diabetes Metabolism Res

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Section: Discussionmentioning

confidence: 99%

Serum levels of pigment epithelium‐derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes

Nakamura

Yamagishi

Adachi

et al. 2008

Diabetes Metabolism Res

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“…Further, the findings that serum level of PEDF was significantly correlated with HOMA-IR index independent on adiponectin and BMI in multiple stepwise regression analysis suggest that non-adipose tissuederived PEDF may also play a role in IR in hypertensive patients. Since expression level of PEDF in porcine liver is associated with body muscularity and obesity [12], liver may be another source of circulating PEDF in human.…”

mentioning

confidence: 99%

Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension

Nakamura

Yamagishi

Adachi

et al. 2010

International Journal of Cardiology

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“…Advances in genome sequencing have led to the discovery of millions of SNP in the chicken genome [26]. Many studies in other species indicated that using the SNP marker is efficient in QTL mapping [4,14,17].…”

Section: Introductionmentioning

confidence: 99%

SNP mapping of QTL affecting growth and fatness on chicken GGA1

et al. 2007

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-An F2 chicken population was established from a crossbreeding between a Xinghua line and a White Recessive Rock line. A total of 502 F2 chickens in 17 full-sib families from six hatches was obtained, and phenotypic data of 488 individuals were available for analysis. A total of 46 SNP on GGA1 was initially selected based on the average physical distance using the dbSNP database of NCBI. After the polymorphism levels in all F0 individuals (26 individuals) and part of the F1 individuals (22 individuals) were verified, 30 informative SNP were potentially available to genotype all F2 individuals. The linkage map was constructed using Cri-Map. Interval mapping QTL analyses were carried out. QTL for body weight (BW) of 35 d and 42 d, 49 d and 70 d were identified on GGA1 at 351-353 cM and 360 cM, respectively. QTL for abdominal fat weight was on GGA1 at 205 cM, and for abdominal fat rate at 221 cM. Two novel QTL for fat thickness under skin and fat width were detected at 265 cM and 72 cM, respectively. QTL / chicken / growth / fatness / single nucleotide polymorphisms

show abstract

Identification of functional candidate genes for body composition by expression analyses and evidencing impact by association analysis and mapping

Cited by 24 publications

References 26 publications

Serum levels of pigment epithelium‐derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes

Serum levels of pigment epithelium‐derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes

Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension

SNP mapping of QTL affecting growth and fatness on chicken GGA1

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