Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension

Nakamura, Kazuo; Yamagishi, Sho‐ichi; Adachi, Hisashi; Matsui, Takanori; Kurita, Yayoi; Imaizumi, Tsutomu

doi:10.1016/j.ijcard.2008.11.169

Cited by 30 publications

(21 citation statements)

References 11 publications

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“…Recently, we, along with others, have found that adipocytes secrete PEDF and serum PEDF level is associated with metabolic syndrome. 19,[32][33][34] However, in this study, enrolled patients were not obese and there was no significant difference in body mass index between HCC and non-HCC patients (22.5 Ϯ 2.1 vs. 22.3 Ϯ 1.9; not significant). Taken together, PEDF expression levels were increased in HCC as a countersystem against neovascularization.…”

Section: Discussionmentioning

confidence: 54%

Pigment Epithelium-Derived Factor Inhibits Lysosomal Degradation of Bcl-xL and Apoptosis in HepG2 cells

Kawaguchi

Yamagishi

Itou

et al. 2010

The American Journal of Pathology

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Pigment epithelium-derived factor (PEDF) has several biological actions on tumor cells , but its effects are cell-type dependent. The aim of this study was to examine the pathophysiological role of PEDF in hepatocellular carcinoma (HCC). PEDF expression was examined in various hepatoma cell lines and human HCC tissues , and was seen in various hepatoma cell lines including HepG2 cells. In human HCC tissues, PEDF expression was higher than in adjacent non-HCC tissues. In addition , serum PEDF levels were higher in HCC patients than in non-HCC patients, and curative treatment of HCC caused significant reductions in serum PEDF levels compared with pretreatment levels. In vitro experiments, camptothecin (CPT) was used to induce apoptosis and the effect of PEDF was

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Section: Discussionmentioning

confidence: 54%

Pigment Epithelium-Derived Factor Inhibits Lysosomal Degradation of Bcl-xL and Apoptosis in HepG2 cells

Kawaguchi

Yamagishi

Itou

et al. 2010

The American Journal of Pathology

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“…Although many factors impact this association, PEDF was demonstrated as a plausible mediator of insulin resistance in mice and elevated in adults with hyperglycemia or impaired glucose tolerance (2,6,12,13). Our data revealed that both PEDF and HOMA-IR are increased in OW vs. NW youth and are positively related to each other, independent of BMI category, with PEDF being the best predictor of HOMA-IR.…”

Section: Discussionmentioning

confidence: 64%

Pigment epithelium-Derived Factor (PEDF) Varies with Body Composition and Insulin Resistance in Healthy Young People

Sunderland¹,

Tryggestad

Wang³

et al. 2012

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context: Pigment epithelium-derived factor (PEDF) was recently implicated as a metabolic regulatory protein because plasma concentration was increased in obese or insulin resistant adults. To our knowledge, circulating PEDF values in children have not been reported. Because PEDF is a predictor of metabolic health in adults, it may have a similar impact on metabolic profiles in children.Objective: The objective of the study was to determine whether PEDF in normal-weight (NW) and overweight/obese (OW) children and young adults varies with age, sex, or body composition or is associated with clinical markers of metabolic disease.Setting: Volunteers were tested at the University of Oklahoma Health Sciences Center.Participants: Ninety-one NW (8 -30 yr old) and 105 OW (8 -35 yr old) males and females participated in the study. Main Outcome Measures:Body composition, blood pressure, arterial compliance, fasting plasma PEDF, glucose, insulin, (used for homeostasis model assessment of insulin resistance), triglycerides, cholesterol (total, low density lipoprotein, and high density lipoprotein), and C-reactive protein.Results: PEDF was 60% higher in the OW vs. NW participants but did not differ between males and females. PEDF was positively correlated with body mass, body mass index, fat and lean mass, fasting insulin, and homeostasis model assessment of insulin resistance in both the NW and OW groups. Multiple regression models revealed that fat and lean mass were significant predictors of circulating PEDF levels independent of age, sex, and body mass index category. Conclusions:Plasma PEDF is elevated in OW youth and is positively associated with insulin resistance. These findings suggest that PEDF may play a role in the development of cardiometabolic dysfunction in youth. (J Clin Endocrinol Metab 97: E2114 -E2118, 2012)

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“…Previous studies have found PEDF levels to be associated with the number of components of metabolic syndrome present in patients, 10 and PEDF levels have also been suggested to play a role in insulin resistance. 11 A further longitudinal study is needed to resolve this issue. There were several important limitations to the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Previous clinical studies have shown that serum levels of PEDF are correlated with adiposity, 9,10 decreased cirrhosis, 8 insulin resistance, 11 renal failure 5,12 and an increase in metabolic syndrome. 10,13 Thus, although PEDF is an exciting new biomarker that is the focus of intriguing research, little is known about the association between PEDF levels and renal function in coronary artery disease (CAD) patients.…”

Section: Introductionmentioning

confidence: 98%

Significance of Plasma Levels of Pigment Epithelium-Derived Factor as Determined by Multidetector Row Computed Tomography in Patients with Mild Chronic Kidney Disease and/or Coronary Artery Disease

et al. 2011

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Little is known about the association between plasma levels of pigment epithelium-derived factor (PEDF), coronary artery disease (CAD) and/or chronic kidney disease (CKD). This study evaluated 289 consecutive patients with chest pain or at least one coronary risk factor who underwent coronary angiography using multidetector row computed tomography (MDCT). Presence of CAD and CKD, CAD severity (i.e. number of significantly stenosed coronary vessels, described as vessel disease [VD]), coronary calcification scores, visceral fat area (VFA), subcutaneous fat area on MDCT, and metabolic biomarkers were recorded. PEDF levels correlated significantly with sex, VFA, CKD presence/hyperuricaemia and highdensity lipoprotein cholesterol levels. PEDF levels were closely associated with CKD and were significantly higher in CKD patients than in non-CKD patients, regardless of the presence of CAD. CKD patients with two-VD or three-VD had higher plasma PEDF levels than non-CKD patients with two-VD or three-VD. It is concluded that PEDF may be associated with CKD regardless of the presence of CAD.

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Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension

Cited by 30 publications

References 11 publications

Pigment Epithelium-Derived Factor Inhibits Lysosomal Degradation of Bcl-xL and Apoptosis in HepG2 cells

Pigment Epithelium-Derived Factor Inhibits Lysosomal Degradation of Bcl-xL and Apoptosis in HepG2 cells

Pigment epithelium-Derived Factor (PEDF) Varies with Body Composition and Insulin Resistance in Healthy Young People

Significance of Plasma Levels of Pigment Epithelium-Derived Factor as Determined by Multidetector Row Computed Tomography in Patients with Mild Chronic Kidney Disease and/or Coronary Artery Disease

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