Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)

N-Hydroxy-Phe-Phe, a new dipeptide, and cytotoxic macrocyclic trichothecenes from the lethal toxic mushroom Podostroma cornu-damae

“…In line with ongoing research endeavors focusing on the discovery of structurally new compounds and unique bioactive compounds, 7–11 we focused on investigating the presence of new metabolites in the MeOH extract of a plate culture of the fungus P. cornu-damae . In our recent study of P. cornu-damae , we successfully identified and isolated eight macrocyclic trichothecenes, namely miophytocen D, roridin E, roridin F, roridin L-2, satratoxin H, 12′-episatratoxin H, satratoxin I, and trichoverritone, including three previously unreported compounds (roridin F, miophytocen D, and satratoxin I).…”

Benefits of Withania somnifera (Ashwagandha) supplementation in obesity

“…There is a growing interest among scientists to discover active substances that prevent adipogenesis and lipogenesis, which could have a role in the prevention of obesity and metabolic disease and can be used as a potential therapeutic method. What has particularly caught the attention of researchers is the finding of natural compounds with antiadipogenic potential [9]. In experimental studies, researchers have suggested that the withasilolides identified in Withania somnifera have anti-adipogenic potential and may be considered for the development of strategies to manage obesity.…”

“…It is sometimes called "Indian ginseng" or "Indian winter cherry" and it is used for its extensive health benefits for millennia as a Rasayana. It occurs in dry regions of India, Sri Lanka, South Africa, and the Mediterranean [8,9]. Many medicinal benefits of Ashwagandha have been reported in the literature, including anti-cancer, anti-inflammatory, antioxidant and hypoglycaemic effects [11].…”

Cytotoxic withanolides from the leaves of Datura stramonium L.

“…The number of new withanolides has skyrocketed, and research into their biological activity has advanced significantly. [6][7][8][9][10][11][12][13] To investigate the diverse structure and biological significance of withanolides derived from Datura stramonium L. leaves, a comprehensive investigation was undertaken. Consequently, six previously unreported withanolides, designated as withastramonolides A-F (1-6), were unearthed alongside nine known withanolides (7)(8)(9)(10)(11)(12)(13)(14)(15) (Figure 1).…”