Benefits of Withania somnifera (Ashwagandha) supplementation in obesity

Abstract

Introduction and purpose: Ashwagandha (fam. Solanaceae) also known as Withania somnifera, is an herb commonly used in traditional Ayurvedic medicine. It is sometimes called Indian ginseng or winter cherry and it is used for its extensive health benefits for millennia as a Rasayana. Ashwagadha supplementation is playing an increasing role not only as an adaptogen, but is beneficial in the context of health in individuals struggling with obesity. This is a growing field of research and the aim of this brief review is to provide an update on the positive effects of Ashwagandha supplementation on the health of those dealing with obesity. 
 Description of the state of knowledge: Ashwagandha has a wide range of positive effects, most common are sedative, anti-stress, immunomodulatory and anti-cancer effects. The literature also draws attention to other results such as binding insulin sensitivity, increasing endurance, effects on adipogenesis and lipogenesis. Ashwagandha lowers blood cortisol levels, inhibits fat accumulation and the expression of genes involved into excessive fat tissue accumulation. 
 Summary: Regular intake of Ashwagandha is associated with health benefits in people struggling with obesity. As an adaptogen with adipogenic potential, Ashwagandha has great potential to participate in future adjunctive obesity therapy and the prevention of other similar and obesity-related diseases, but further research is needed in this area.

Herbal-based Nutraceuticals in Management of Lifestyle Diseases: Experience from Indian Population

“…While acknowledging its promising effects, the review highlighted the need for extensive, long-term clinical trials to conclusively validate its efficacy and safety. 18 A recent systematic review published in a scientific jour-nal specializing in herbal medicine found the evidence supporting Ashwagandha's effectiveness in managing diabetes to be weak. The review highlights the need for further research to fully explore its potential benefits in this area.…”