Identification and quantitation assays for intact tablets of two related pharmaceutical preparations by reflectance near-infrared spectroscopy: validation of the procedure

Simultaneous spectrophotometric determination of lamivudine and zidovudine in fixed dose combinations using multivariate calibration

“…31 They are not clearly defined, however, for multivariate calibration methods, although the literature indicates various strategies. 32,34,35 In this work, similar to Blanco, 36 validation was performed to evaluate these parameters: sensibility, selectivity, limit of detection, robustness, accuracy and precision. In the robustness test the same variables were evaluated as in the derivative methods.…”

Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

“…NIR has also displayed great potential in predicting the properties of the ® nal dosage form. In addition to tablet hardness and ® lm-coat thickness, NIR has been used to predict the dissolution rate of dosage forms (Kirsch & Drennen 1995), drug content (Blanco et al 1998a(Blanco et al , 2000Chen et al 2001) and quantifying the decomposition of acetylsalicylic acid into salicylic acid in aspirin tablets (Drennen & Lodder 1990). Many models can be combined and a series of tablet properties can be predicted from a single spectrum (Kirsch & Drennen 1995).…”

Determination of amoxicillin content in powdered pharmaceutical formulations using DRIFTS and PLS

“…Instrumentation analytical methods that are neither destructive nor produce residues have been increasingly investigated for the identification and quantification of active ingredients, using infrared spectroscopy (Blanco et al, 2000a;Blanco et al, 2000b;Blanco et al, 2001;Braga, Poppi, 2004;Pasquini, 2003;Sun, Xiang, An, 2004;Yang, Irudayaraj, 2002).…”

“…The interface between chemometric tools and the data obtained by infrared methods offers new possibilities for the quantification and qualification of pharmaceutical drugs (Blanco et al, 2000a;Blanco et al, 2000b;Blanco et al, 2001;Pasquini, 2003;Yang, Irudayaraj, 2002;Ferrão, Davanzo, 2005). On top of that, because it is a simple, easily obtained and non-destructive method, its procedures are appropriate for pharmaceutical formulations.…”

“…On top of that, because it is a simple, easily obtained and non-destructive method, its procedures are appropriate for pharmaceutical formulations. Such methods have allowed to compare (Sabin, Ferrão, Furtado, 2004;Neumann et al, 2004 and quantify (Blanco et al, 2000b;Blanco et al, 2001;Yang, Irudayaraj, 2002;Sun, Xiang, An, 2004;Konzen et al, 2003) several drugs during different manufacturing stages.…”