Identification and quantification of phenolic compounds in Salvia cadmica Boiss. and their biological potential

Piątczak, Ewelina; Owczarek, Aleksandra; Lisiecki, Paweł; Gonciarz, Weronika; Kozłowska, Weronika; Szemraj, Magdalena; Chmiela, Magdalena; Kiss, Anna K.; Olszewska, Monika A.; Grzegorczyk-Karolak, Izabela

doi:10.1016/j.indcrop.2020.113113

Cited by 16 publications

(18 citation statements)

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“…At 30 min, i.e., when the reaction was completed, the shoots demonstrated a significantly higher DPPH activity (25.9 µg/mL) than the roots (32.9 µg/mL); however, at the initial reading, a lower EC 50 value was observed for the root extract, indicating more rapid DPPH radical binding. The DPPH test is commonly used for assessing the antioxidant potential of sage species, and our findings for S bulleyana shoots were comparable to those other sages with strong antioxidant activity, such as extracts of aerial parts of S. verticillata (33.4 µg/mL) [14], S. officinalis (23.2 µg/mL) [32], and S. cadmica (34.91 µg/mL) [20], or shoots of S. elegans (10.7 µg/mL) and S. greggii (21.1 µg/mL) [15].…”

Section: Antioxidant Propertiessupporting

confidence: 81%

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Phytochemical Profile and Antioxidant Activity of Aerial and Underground Parts of Salvia bulleyana Diels. Plants

et al. 2020

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Plants have been used for medical purposes since ancient times. However, a detailed analysis of their biological properties and their associated active compounds is needed to justify their therapeutic use in modern medicine. The aim of the study was to identify and quantify the phenolics present in hydromethanolic extracts of the roots and shoots of the Chinese Salvia species, Salvia bulleyana. The qualitative and quantitative analyses were carried out by ultrahigh-performance liquid chromatography with electrospray ionization mass spectrometry detection (UHPLC-PDA-ESI-MS), and high-performance liquid chromatography with photodiode array (HPLC-PDA) detection. The extracts of S. bulleyana were also screened for their antioxidant activity using ferric ion (Fe3+) reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH), diammonium 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate) cation (ABTS), superoxide radical anion (O2•–), and inhibition of lipid peroxidation assays. The S. bulleyana extracts were found to contain 38 substances, of which 36 were phenols, with a total level of 14.4 mg/g DW (dry weight) in shoots, and 23.1 mg/g DW in roots. Twenty-eight phenols were polyphenolic acids or their derivatives, the most abundant in shoots being rosmarinic acid, and in roots, salvianolic acid K followed by rosmarinic acid. The other major phenolic acids were caffeic acid, caffeoyl-threonic acids, isomers of lithospermic acid, salvianolic acid F, salvianolic acid B, and yunnaneic acid E. In addition to polyphenolic acids, nine flavonoids were detected in the shoot extract. While both extracts showed significant antioxidant activity, the shoot extract, containing both polyphenolic acids and flavonoids, demonstrated a slightly greater antioxidant potential in some of the anti-radical tests than the roots. However, the root extract proved to be slightly more effective in the lipid peroxidation inhibition test. Thus, S. bulleyana was demonstrated as a promising source of antioxidants, and worthy of further more detailed studies.

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Section: Antioxidant Propertiessupporting

confidence: 81%

“…Peak 21 was identified as salvianolic acid K, as described previously for S. bulleyana [13], and peak 16 as its isomer, found previously in S. cadmica Boiss. [20].…”

Section: Identification Of Phenolic Acid Derivativesmentioning

confidence: 99%

Phytochemical Profile and Antioxidant Activity of Aerial and Underground Parts of Salvia bulleyana Diels. Plants

et al. 2020

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“…Free radicals are increased by overexposure to UV rays, aging, and smoking. Phenolic compounds are one of the most important sources of antioxidants [51]. Table 7 compares the amount of phenolic compounds in Pistacia vera L. hull in this study and similar research.…”

Section: Hplc Analysissupporting

confidence: 52%

Biosynthesis of Organic Nanocomposite Using Pistacia vera L. Hull: An Efficient Antimicrobial Agent

Bakhshi

Bagherzade

2021

Bioinorganic Chemistry and Applications

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Here presented a quick and easy synthesis of copper nanoparticles (CuNPs). Pistachio hull extract has been used as a reducing and stabilizing agent in the preparation of CuNPs. This biosynthesis is a kind of supporter of the environment because chemical agents were not used to making nanoparticles, and on the other hand, it prevents the release of pistachio waste in nature and its adverse effects on nature. The biosynthesized CuNPs and CuNPs/silver Schiff base nanocomposite (CSS NC) were characterized by UV-VIS spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopy (EDS). CuNP and CSS NC antimicrobial activity was examined by both well diffusion and determination MIC methods against four bacteria Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa and two fungi Aspergillus Niger and Candida albicans. CuNPs and CSS NC showed significant antimicrobial activity on the samples, preventing the growth of bacteria and fungi at very low concentrations. CuNPs and CSS NC had the greatest effect on Escherichia coli bacteria and Aspergillus niger fungi. Phenolic compounds are one of the most important antioxidants that are involved in various fields, including pharmacy. Pistacia vera hull is a rich source of phenolic compounds. In this study, the most phenolic compound in Pistacia vera hull is gallic acid and rutin, which has been identified by HPLC analysis. In this study, Pistacia vera hull essential oil analysis was performed by the GC-MS method, in which α-pinene, D-limonene, and isobornyl acetate compounds constitute the highest percentage of Pistacia vera hull essential oil.

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“…In the case of superoxide anion (O 2 •− ), the investigated S. bulleyana hairy root extract had a slightly weaker activity (IC 50 = 69.5 µg/mL) than that of the control (BHT); however, its potential against this radical was still similar or greater compared to other species of sage [ 51 , 52 ]. Quenching capacity towards O 2 •− is especially important because it plays an essential role in the oxidative damage in the human body and hence has significance in generating oxidative stress-related civilization diseases.…”

Section: Resultsmentioning

confidence: 99%

“…The MICs of methanol extracts from S. xanthocheila , S. santolinifolia , S. limbata shoots against six different Gram-negative and Gram-positive bacteria were also in the range of 1.25–5 mg/mL; however, in the same experiment, S. sclarea and S. eremophila showed a much stronger effect against S. epidemidis (MIC 0.3 mg/mL) [ 49 ]. The hydromethanolic extracts of S. cadmica shoot (1.25–5 mg/mL) also demonstrated similar activity against selected Gram-positive bacteria [ 52 ], while the root extract was more active against Staphylococcus strains (0.156–2.5 mg/mL).…”

Section: Resultsmentioning

confidence: 99%

The Antioxidant, Cytotoxic and Antimicrobial Potential of Phenolic Acids-Enriched Extract of Elicited Hairy Roots of Salvia bulleyana

et al. 2022

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Hairy root cultures are valuable sources of a range of phytochemicals. Among them, Salvia bulleyana root culture is a promising source of polyphenols, especially rosmarinic acid (RA), a phenolic acid depside with pleiotropic activity and a wide application in medicine and cosmetology. The aim of the study was to enhance the culture productivity by finding suitable elicitation protocol and to determine its biological potential in terms of antioxidant, anticancer and antimicrobial properties. The total content of phenols and the levels of particular constituents in root extracts were analyzed using HPLC-PDA. Among four elicitors tested (yeast extract; methyl jasmonate, MJA; trans-anethol; and cadmium chloride), MJA was found to be the most effective. The greatest boost in phenolic production (up to 124.4 mg/g dry weight) was observed after three-day treatment with MJA at 100 µM, with an almost 100% improvement compared to the controls (non-treated root culture). The hydromethanolic extract from the elicited culture exhibited strong antioxidant activity with IC50 values of 11.1 µg/mL, 6.5 µg/mL and 69.5 µg/mL for DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid)) and superoxide anion radical, respectively. Moreover, in concentrations of 0.5–5 mg/mL the extract inhibited the growth of LoVo, AGS and HeLa cell lines, but was safe for the L929 cells up to the concentration of 5 mg/mL. The extract also exhibited moderate antimicrobial activity. Thus, the results confirmed that elicitation can be a beneficial strategy for increase the phenolic acid biosynthesis in hairy roots of S. bulleyana, and that such a highly productive culture can show significant biological potential.

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Identification and quantification of phenolic compounds in Salvia cadmica Boiss. and their biological potential

Cited by 16 publications

References 50 publications

Phytochemical Profile and Antioxidant Activity of Aerial and Underground Parts of Salvia bulleyana Diels. Plants

Phytochemical Profile and Antioxidant Activity of Aerial and Underground Parts of Salvia bulleyana Diels. Plants

Biosynthesis of Organic Nanocomposite Using Pistacia vera L. Hull: An Efficient Antimicrobial Agent

The Antioxidant, Cytotoxic and Antimicrobial Potential of Phenolic Acids-Enriched Extract of Elicited Hairy Roots of Salvia bulleyana

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