Identification and functional annotation of metabolism‐associated lnc<scp>RNA</scp>s and their related protein‐coding genes in gastric cancer

Mo, Xiaoyan; Li, Tianwen; Xie, Youhua; Zhu, Linwen; Xiao, Bingxiu; Liao, Qi; Guo, Junming

doi:10.1002/mgg3.427

Cited by 16 publications

(12 citation statements)

References 34 publications

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“…In recent years, more and more tumor‐associated lncRNAs have been discovered . A large number of published works have reported that these lncRNAs play an important role in multiple tumors . Our previous research shows that lncRNA SNHG17 can promote the proliferation of CRC cells by inhibiting the expression of p57 .…”

Section: Discussionmentioning

confidence: 99%

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Long noncoding RNA MAPKAPK5‐AS1 promotes colorectal cancer proliferation by partly silencing p21 expression

Hui

Wang

et al. 2018

Cancer Science

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Colorectal cancer (CRC) is the third most common malignancy in the world, and long noncoding RNA (lncRNA) plays a critical role in carcinogenesis. Here, we report a novel lncRNA, MAPKAPK5‐AS1, that acts as a critical oncogene in CRC. In addition, we attempted to explore the functions of MAPKAPK5‐AS1 on tumor progression in vitro and in vivo. Quantitative RT‐PCR was used to examine the expression of MAPKAPK5‐AS1 in CRC tissues and cells. Expression of MAPKAPK5‐AS1 was significantly upregulated in 50 CRC tissues, and increased expression of MAPKAPK5‐AS1 was found to be associated with greater tumor size and advanced pathological stage in CRC patients. Knockdown of MAPKAPK5‐AS1 significantly inhibited proliferation and caused apoptosis in CRC cells. We also found that p21 is a target of MAPKAPK5‐AS1. In addition, we are the first to report that MAPKAPK5‐AS1 plays a carcinogenic role in CRC. MAPKAPK5‐AS1 is a novel prognostic biomarker and a potential therapeutic candidate for CRC cancer.

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Section: Discussionmentioning

confidence: 99%

“…18 A large number of published works have reported that these lncRNAs play an important role in multiple tumors. [19][20][21][22][23] Our previous research shows that lncRNA SNHG17…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA MAPKAPK5‐AS1 promotes colorectal cancer proliferation by partly silencing p21 expression

Hui

Wang

et al. 2018

Cancer Science

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“…They are divided into antisense, sense, bidirectional, intronic, and intergenic categories . LncRNAs play important roles in cancer incidence and development . Furthermore, lncRNAs regulate metabolism in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Global expression profiling of metabolic pathway‐related lncRNAs in human gastric cancer and the identification of RP11‐555H23.1 as a new diagnostic biomarker

Chen

et al. 2018

Clinical Laboratory Analysis

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Background: Long noncoding RNAs (lncRNAs) have roles in regulating metabolism; however, the global expression profile of metabolic pathway-associated lncRNAs in gastric cancer is unknown. The purpose of our study was to examine metabolic pathway-related lncRNAs in gastric cancer and their possible diagnostic values. Methods: Differential expression patterns of metabolic pathway-related lncRNAsbetween gastric cancer and paired nontumor tissues were detected using metabolic pathway-associated lncRNA microarrays. The expression of RP11-555H23.1, one representative metabolic pathway-associated lncRNA, was validated using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). The associations between RP11-55H23.1 expression and the clinicopathological features of gastric cancer patients were analyzed. A receiver operating characteristic (ROC) curve was further established.Results: A total of 114 differentially expressed metabolic pathway-associated lncR-NAs (fold change >2, P < 0.05) between cancer and nontumor tissues were found (GEO No. GSE96856). Among them, TUG1, RP11-555H23.1, RP1-257I20.13, UGP2, GCSHP3, and XLOC_000889 lncRNAs were downregulated more than sixfold in gastric cancer tissues. In contrast, RP11-605F14.2, TBC1D3P5, BC130595, LINC00475, RP11-19P22.6, BC080653, XLOC_004923, AFAP1-AS1, EPB49, and RP11-296I10.3 lncRNAs were upregulated more than sixfold in gastric cancer tissues.We further demonstrated that RP11-555H23.1 expression was significantly correlated with TNM stage (P = 0.038). The area under the ROC curve (AUC) was 0.65, and the specificity and sensitivity were 62% and 81%, respectively. Conclusions:Metabolic pathway-associated lncRNAs play an important role in the occurrence of gastric cancer, and metabolic pathway-associated lncRNAs, such as RP11-555H23.1, may represent novel biomarkers of gastric cancer. K E Y W O R D S biomarker, gastric cancer, long noncoding RNA, metabolic pathway, RP11-555H23.1 S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Mo X, Wu Y, Chen L, et al. Global expression profiling of metabolic pathway-related lncRNAs in human gastric cancer and the identification of RP11-555H23.1 as a new diagnostic biomarker. J Clin Lab

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“…In fact, an increasing number of lncRNAs have been identified to be related to numerous kinds of diseases, including GC. For example, through the expression analysis of metabolic pathway‐related lncRNAs and protein‐coding genes, a dozen of lncRNAs were functionally annotated and discovered to be important in GC . DGCR9, another lncRNA up‐regulated in GC, was shown to promote the tumorigenesis of GC .…”

Section: Discussionmentioning

confidence: 99%

Function and regulation annotation of up‐regulated long non‐coding RNA LINC01234 in gastric cancer

Zhu

Luo

Korakkandan

et al. 2020

Clinical Laboratory Analysis

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Background Accumulated evidences indicate that long non‐coding RNAs (lncRNAs) participate in many biological mechanisms. Moreover, it acts as an essential regulator in various human diseases such as gastric cancer (GC). Nevertheless, the comprehensive regulatory roles and clinical significance of most lncRNAs in GC are not fully understood. Methods In this research, our aim was to investigate the underlying mechanism of lncRNA LINC01234 in GC. Firstly, the usage of qRT‐PCR helped to establish expression pattern of LINC01234 in GC tissues. Following this, appropriate statistical tests were applied to analyze the relation between expression level and clinicopathological factors. Ultimately, potential functions and regulatory network of LINC01234 were concluded via GSEA and a series of bioinformatics tools or databases, respectively. Results Consequently, at the end of research we found LINC01234 is up‐regulated in GC tissues in comparison with adjacent normal tissues. Furthermore, its expression level is correlated with differentiation of patients with GC. It is also important to highlight bioinformatics analysis revealed that LINC01234 is involved in cancer‐associated pathways such as cell cycle and mismatch repair. Also, regulatory network of LINC01234 presented a probability in the involvement of tumorigenesis through regulating cancer‐associated genes. Conclusion Overall, our results suggested that LINC01234 may play a crucial role in GC.

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Identification and functional annotation of metabolism‐associated lncRNAs and their related protein‐coding genes in gastric cancer

Cited by 16 publications

References 34 publications

Long noncoding RNA MAPKAPK5‐AS1 promotes colorectal cancer proliferation by partly silencing p21 expression

Long noncoding RNA MAPKAPK5‐AS1 promotes colorectal cancer proliferation by partly silencing p21 expression

Global expression profiling of metabolic pathway‐related lncRNAs in human gastric cancer and the identification of RP11‐555H23.1 as a new diagnostic biomarker

Function and regulation annotation of up‐regulated long non‐coding RNA LINC01234 in gastric cancer

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