2018
DOI: 10.1111/cas.13838
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Abstract: Colorectal cancer (CRC) is the third most common malignancy in the world, and long noncoding RNA (lncRNA) plays a critical role in carcinogenesis. Here, we report a novel lncRNA, MAPKAPK5‐AS1, that acts as a critical oncogene in CRC. In addition, we attempted to explore the functions of MAPKAPK5‐AS1 on tumor progression in vitro and in vivo. Quantitative RT‐PCR was used to examine the expression of MAPKAPK5‐AS1 in CRC tissues and cells. Expression of MAPKAPK5‐AS1 was significantly upregulated in 50 CRC tissues… Show more

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Cited by 30 publications
(29 citation statements)
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“…The MK5 gene has been proven to have dual characteristics in cancer progression [36], hence, the effects of high expression of MK5 on OS in the TCGA database were in contradiction with ours. MK5-AS1 was found to be mainly located in the cytoplasm, which did not correspond with a previous study [27] of MK5-AS1 showing that it was mainly located in the nucleus.…”
Section: Discussioncontrasting
confidence: 99%
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“…The MK5 gene has been proven to have dual characteristics in cancer progression [36], hence, the effects of high expression of MK5 on OS in the TCGA database were in contradiction with ours. MK5-AS1 was found to be mainly located in the cytoplasm, which did not correspond with a previous study [27] of MK5-AS1 showing that it was mainly located in the nucleus.…”
Section: Discussioncontrasting
confidence: 99%
“…Database and clinical specimen analysis demonstrated that MK5-AS1 was upregulated in CRC and induced cell proliferation and metastasis. Moreover, a change in MK5-AS1 levels was correlated with advanced TNM stage, including lymph node metastasis, peripheral metastasis, pathological staging, tumor development and tumorigenesis, which is consistent with previous reports [27]. However, Wang et al mainly focused on MK5-AS1 enhancing CRC development by targeting p21 [27], and the mechanism of MK5-AS1 promoting tumor metastasis and invasion was poorly de ned.…”
Section: Discussionsupporting
confidence: 84%
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“…The MK5 gene has been proven to have dual characteristics in tumorigenesis and development [35]; hence, the effects of high expression of MK5 on OS in the TCGA database were in contradiction with ours. MK5-AS1 was found to be mainly located in the cytoplasm, which did not correspond with a previous study [27] of MK5-AS1…”
Section: Discussioncontrasting
confidence: 99%
“…The lncRNA MAPKAPK5-AS1 (also known as MK5-AS1) is located on chromosome 12q24.12 and has been demonstrated to act as an oncogenic molecule [27]. In this study, we identified MK5-AS1 by screening publicly available expression profiling data from CRC and integrating bioinformatics appropriate medium containing 10% FBS for approximately 14 days, and the medium was replaced every 5 days.…”
Section: Introductionmentioning
confidence: 99%