Identification and chemical profiling of anti-alcoholic liver disease biomarkers of ginseng Huang jiu using UPLC-Q-Orbitrap-HRMS and network pharmacology-based analyses

Wu, Yongxi; Cai, Yongyu; Ma, Liang; Li, Fangtong; Zhang, Meiyu; Wang, Yizhu; Zheng, Fei; Pi, Zifeng; Hao, Yue

doi:10.3389/fnut.2022.978122

Cited by 3 publications

(1 citation statement)

References 34 publications

(16 reference statements)

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“…Ginkgo leaves are the GBE raw materials and contain abundant pharmaceutical ingredients. Thus, it is also common that homemade ginkgo wine is manufactured by directly immersing ginkgo leaves in Chinese Baijiu, just like the method of processing most traditional critical herbal products (e.g., ginseng wine) in east Asia [ 12 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Values and Potential Risks Evaluation of Ginkgo biloba Leaf Extract (GBE) Drinks Made from the Leaves in Autumn as Dietary Supplements

Shi

et al. 2022

Molecules

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Ginkgo tea and ginkgo wine are two familiar Ginkgo biloba leaf extract (GBE) drinks in the form of dietary supplements (DS) used for healthcare in east Asia. Nevertheless, a comprehensive evaluation of their safety and efficacy is still lacking. In this study, GBE drinks were prepared from naturally newly senescent yellow leaves (YL) and green leaves (GL) in autumn. Their total flavonoids, antioxidant capacity and prescribed ingredients were investigated. In brief, the proportions of total flavonoids, total flavonol glycosides (TFs), total terpene trilactones (TTLs) and ginkgolic acids in the GBE drinks all did not meet the standards of worldwide pharmacopoeias. Specifically, the levels of TFs in the ginkgo tea prepared from YL were significantly higher than that prepared from GL. Further analyses revealed a substandard ratio of isorhamnetin/quercetin and an accumulation of leaf-age-related compounds, which were both unqualified. The proportions of specific TTLs varied between the ginkgo tea and ginkgo wine, although no significant differences were detected in terms of the total levels of TTLs. Noticeably, numerous biflavones and thousands of times over the limiting concentration of ginkgolic acids, including newly identified types, were only detected in ginkgo wine. Finally, the use of the GBE drinks as DSs was comprehensively evaluated according to the acceptable daily intake. This study showed the limited healthcare effects of GBE drinks despite their powerful antioxidant capacity.

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Section: Introductionmentioning

confidence: 99%

Medicinal Values and Potential Risks Evaluation of Ginkgo biloba Leaf Extract (GBE) Drinks Made from the Leaves in Autumn as Dietary Supplements

Shi

et al. 2022

Molecules

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Combination of UHPLC‐Q Exactive‐Orbitrap MS, Bioinformatics and Molecular Docking to Reveal the Mechanism of Huan‐Lian‐Jie‐Du Decoction in the Treatment of Diabetic Encephalopathy

Cao

Liang

Zhang

et al. 2023

Chemistry & Biodiversity

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Diabetic encephalopathy (DE) is a serious complication of diabetes, which affects patients′ quality of life. We aimed to explore HLJDD in the treatment of DE by LC/MS and bioinformatics. UPLC‐Q Exactive‐Orbitrap MS was employed to clarify the compounds. The modules and hub targets of DE were gained from WGCNA. Subsequently, an Herb‐Compound‐Target network was constructed and enrichment analysis was used. In addition, a protein‐protein interaction (PPI) network was constructed and molecular docking was used to verify the above analysis. As result, 138 compounds and 10 prototypes in brain were identified. In network pharmacology, 8 modules and 5692 hub targets were obtained from WGCNA. An Herb‐Compound‐Target network was constructed by 4 herbs, 10 compounds and 56 targets. The enrichment analysis showed that the treatment of DE with HLJDD involve oxidative stress and neuroprotection. Beside, SRC, JUN, STAT3, MAPK1 and PIK3R1 were identified and as hub targets of HLJDD in treating DE. Moreover, Molecular docking showed that five hub targets had strong affinity with the corresponding alkaloids. Therefore, we explored the underlying mechanisms of HLJDD in the treatment of DE and to provide the theoretical and scientific basis for subsequent experimental studies and clinical applications.

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Ginseng fermentation solution affects the gut microbiota in zebrafish with alcoholic liver disease via PI3K/Akt pathway

Wu,

Liu,

Ren

et al. 2024

Phytomedicine

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Identification and chemical profiling of anti-alcoholic liver disease biomarkers of ginseng Huang jiu using UPLC-Q-Orbitrap-HRMS and network pharmacology-based analyses

Cited by 3 publications

References 34 publications

Medicinal Values and Potential Risks Evaluation of Ginkgo biloba Leaf Extract (GBE) Drinks Made from the Leaves in Autumn as Dietary Supplements

Medicinal Values and Potential Risks Evaluation of Ginkgo biloba Leaf Extract (GBE) Drinks Made from the Leaves in Autumn as Dietary Supplements

Combination of UHPLC‐Q Exactive‐Orbitrap MS, Bioinformatics and Molecular Docking to Reveal the Mechanism of Huan‐Lian‐Jie‐Du Decoction in the Treatment of Diabetic Encephalopathy

Ginseng fermentation solution affects the gut microbiota in zebrafish with alcoholic liver disease via PI3K/Akt pathway

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