Ginseng fermentation solution affects the gut microbiota in zebrafish with alcoholic liver disease via PI3K/Akt pathway

The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway

“…The KEGG pathway enrichment analysis showed that SSAE alleviates ALD by acting on PI3K/AKT and NFκB pathways, The PI3K/AKT signaling pathway can regulate the release of inflammatory factors and the formation of enzymes related to proliferation, inflammation, and apoptosis, and participates in the pathology of ALD. The PI3K/AKT/IKK signaling pathway is widely present and in an upregulated state of expression in abnormal hepatocytes [ 35 ], PI3K/AKT/IKK phosphorylation activates IL-1β and induces overexpression of pro-inflammatory factors TNF-α and IL-6, mediating the development of liver inflammation in rats [ 36 ]. IKK activates the phosphorylation of IκB and the subsequent nuclear translocation of NFκB, increases the level of inflammatory mediators, may underly the immune defense and immune regulation in ALD [ [37] , [38] , [39] ].…”