Identification and characterization of proteins in amniotic fluid that are differentially expressed before and after antenatal corticosteroid administration

Lee, Woo Jung; Park, Joong Shin; Norwitz, Errol R.; Kim, Byoung Jae; Park, Chan Wook; Jun, Jong Kwan; Syn, Hee Chul

doi:10.1016/j.ajog.2010.01.056

Cited by 9 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, SELDI-TOF mass spectrometry is a powerful technique in which significant and meaningful results can be obtained with a relatively small number of samples as previous reported. 33,34 Additional prospective studies with larger sample numbers would be required to confirm and further validate these observations. Experiments are currently underway to characterize the different apo CIII and apo AII isoforms identified on proteomic analysis to see whether these individual peaks can better inform our predictive model.…”

Section: Discussionmentioning

confidence: 94%

Identification of Proteomic Biomarkers in Maternal Plasma in the Early Second Trimester That Predict the Subsequent Development of Gestational Diabetes

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 94%

Identification of Proteomic Biomarkers in Maternal Plasma in the Early Second Trimester That Predict the Subsequent Development of Gestational Diabetes

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…Tandem mass spectrometry (MS/MS) of peptides generated by the in-gel tryptic digestions of pooled AF samples was performed by nanoelectrospray ionization on a Q-TOF-2 mass spectrometer (Micromass, Manchester, UK) as reported previously. 24 In brief, a voltage of 1 kV was applied to the nanoelectrospray needles in the ion source combined with nitrogen. The mass spectrometer is operated in an automatic data-dependent MS/MS mode.…”

Section: Identification Of the Proteins Of Interest By In-gel Tryptic Digestion And Electrospray Ionization Ms/msmentioning

confidence: 99%

Proteomic Biomarkers in Second Trimester Amniotic Fluid That Identify Women Who Are Destined to Develop Preeclampsia

Park

Norwitz

et al. 2012

Reprod. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cystatin is a candidate marker of inflammation. A human prothrombin fragment-2 (F2) inhibits the release of nitric oxide (NO), PGE2, and pro-inflammatory cytokines through suppression of expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA [58, 59]. F2 also suppresses the LPS-induced NF-kappaB activation [59].…”

Section: Factors Predictive Of Preterm Birthmentioning

confidence: 99%

Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth

Noguchi

Sado

Naruse

et al. 2010

Mediators of Inflammation

View full text Add to dashboard Cite

Objective. Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and RAGE expression, their ligands, and signaling in preterm birth. Research Design and Methods. A systematic search was performed in the electronic databases PubMed and ScienceDirect up to July 2010, combining the keywords “preterm birth,” “TLR”, “RAGE”, “danger signal”, “alarmin”, “genomewide,” “microarray,” and “proteomics” with specific expression profiles of genes and proteins. Results. This paper provides data on TLR and RAGE levels and critical downstream signaling events including NF-kappaB-dependent proinflammatory cytokine expression in preterm birth. About half of the genes and proteins specifically present in preterm birth have the properties of endogenous ligands “alarmin” for receptor activation. The interactions between the TLR-mediated acute inflammation and RAGE-mediated chronic inflammation have clear implications for preterm birth via the TLR and RAGE system, which may be acting collectively. Conclusions. TLR and RAGE expression and their ligands, signaling, and functional activation are increased in preterm birth and may contribute to the proinflammatory state.

show abstract

Identification and characterization of proteins in amniotic fluid that are differentially expressed before and after antenatal corticosteroid administration

Cited by 9 publications

References 53 publications

Identification of Proteomic Biomarkers in Maternal Plasma in the Early Second Trimester That Predict the Subsequent Development of Gestational Diabetes

Identification of Proteomic Biomarkers in Maternal Plasma in the Early Second Trimester That Predict the Subsequent Development of Gestational Diabetes

Proteomic Biomarkers in Second Trimester Amniotic Fluid That Identify Women Who Are Destined to Develop Preeclampsia

Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth

Contact Info

Product

Resources

About