Identification and Characterization of Clinically Isolated Biofilm-forming Gram-positive Rods from Teeth Associated with Persistent Apical Periodontitis

Endodontic Pathogens Causing Deep Neck Space Infections: Clinical Impact of Different Sampling Techniques and Antibiotic Susceptibility

“…Because of the urgency of proper treatment for these patients, the antibiotics used have to reliably affect the suspected causative microbiological spectrum. The most common pathogens that cause endodontic infections may vary depending on the geographical region (14,15), differences in sampling techniques, and laboratory procedures (9,10,13,(16)(17)(18).…”

Food-borne Enterococci Integrate Into Oral Biofilm: An In Vivo Study

“…The proof of bacterial growth within the biofilm structure enables the survival of bacteria in endodontic infections. This was reported even for species that are not frequently isolated from infected root canals, such as Bacillus subtilis (36). The fact that E. faecalis was shown to reside within different layers of the oral biofilm indicates the ability of enterococci not only to aggregate with different oral bacteria in the dental oral supragingival plaque but also to be part of the persistent biofilm in infected root canals, leading to failure of endodontic therapy.…”

Complete Genome Sequence of Rothia mucilaginosa DY-18: A Clinical Isolate with Dense Meshwork-Like Structures from a Persistent Apical Periodontitis Lesion

“…If allowed to progress, apical periodontitis can cause the destruction of supporting connective tissues and bones, ultimately resulting in tooth loss. The ability to produce extracellular matrix and to form biofilms is recently considered to be crucial for microorganisms that are present in a root canal to resist the intraroot canal procedures of disinfection, to occupy apical foramina of teeth, and to cause persistent chronic inflammatory lesions [9,[12][13][14]. For future studies to genetically clarify the mechanism of matrix production, we have determined a complete genome sequence of DY-18 with a combined strategy of pyrosequencing and paired-end sequencing.…”