“…The human homologue TSG101 has been isolated and mapped to chromosome 11p, bands 15.1-15.2 (Li et al, 1997), a region known to exhibit a high incidence of loss of heterozygosity in a variety of human malignancies (Ali et al, 1987;Baffa et al, 1996;Byrne et al, 1993;Lothe et al, 1993;Ludwig et al, 1991;Reeve et al, 1989;Shaw and Knowles, 1995;Weitzel et al, 1994), suggesting that TSG101 might be a tumor suppressor. Although no genomic deletion has been identified, aberrant transcripts can be found in various tumors and their matched normal tissues (Carney et al, 1998;Chang et al, 1999;Lee and Feinberg, 1997;Lin et al, 1998a,b;Wang et al, 2000;Willeke et al, 1998), including thyroid tumors (McIver et al, 2000). Abnormally spliced transcripts of TSG101 have been found to very closely correlate with tumor grade and p53 mutation in breast cancer samples.…”