ICTV Virus Taxonomy Profile: Adenoviridae 2022

Abstract

The family Adenoviridae includes non-enveloped viruses with linear dsDNA genomes of 25–48 kb and medium-sized icosahedral capsids. Adenoviruses have been discovered in vertebrates from fish to humans. The family is divided into six genera, each of which is more common in certain animal groups. The outcome of infection may vary from subclinical to lethal disease. This is a summary of the ICTV Report on the family Adenoviridae, which is available at ictv.global/report/adenoviridae.

Simian adenoviruses: Molecular and serological survey in monkeys and humans in Thailand

“…Adenovirus genomes range from 26 to 48 Kbp in size and encode approximately 40 structural and non-structural proteins involved in host transcriptional modulation, viral DNA replication, virion assembly and maturation, and sabotage of the host immune response. The Adenoviridae family is composed of six genera ( Atadenovirus , Aviadenovirus , Ichtadenovirus , Mastadenovirus , Siadenovirus, and Testadenovirus ), and viruses in these groups infect mammals, birds, fish, reptiles, and amphibians [ 1 ]. Members of the genus Mastadenovirus infect a wide range of mammals, including humans, non-human primates (NHPs), and many others (cattle, dogs, deer, horses, pigs, sheep, rodents, bats, dolphins, sea lions, and polar bears).…”

“…The classification of virus species within the genus depends on several characteristics, including genomic properties, serological properties, host range, and oncogenicity in rodents. Currently, the genus and species demarcation is based mainly on genomic criteria, i.e., phylogenetic distance, but also on genome organization and biological characteristics [ 1 ]. Mastadenovirus members currently include >50 species; among them are seven Human mastadenovirus (HAdV-A to -G) and nine Simian mastadenovirus (SAdV-A to —I) species [ 1 ].…”

No Genus-Specific Gene Is Essential for the Replication of Fowl Adenovirus 4 in Chicken LMH Cells

“…Adenoviridae is classified into six genera, among which Mastadenoviruses infect mammalian hosts exclusively while Aviadenoviruses have been found only in birds ( 1 ). Mastadenoviruses, especially human adenovirus C (HAdV-C), have been intensively studied and constructed as gene transfer vectors ( 2 – 4 ).…”

Molecular characterization of aviadenovirus serotypes and pathogenicity of the identified adenovirus in broiler chickens

“…This increases the chances of disease transmission and causes substantial economic losses, particularly in the absence of vaccine control. Adenovirus infections are caused by non-enveloped icosahedral viruses of the genus aviadenovirus in the family adenoviridae with linear double-stranded DNA ranging in size from 25 to 46 kbp ( Benko et al., 2005 ; Adair and Smyth, 2008 ).…”