Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus-pituitary-adrenal axis <i>in vitro</i>

Kong, Lingwen; Liang, Xin; Liu, A.; Yang, Xuelian; Luo, Qingli; Lv, Yubao; Dong, Jing

doi:10.1111/ced.13735

Cited by 8 publications

(5 citation statements)

References 25 publications

(30 reference statements)

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“…Pretreatment with icariin was also able to promote the activation of GC, and it showed a potential effect in improving insufficient GC secretion in chronic inflammation. 38 Icariin can significantly inhibit lipopolysaccharide (LPS)-induced cell inflammation, downregulate the expression of inflammatory factors such as NF-κB, AP-1, and STAT3, and partially restore the expression of GRα to decrease GC-resistance. 39 Tang Xiufeng et al demonstrated that combining the extracts of Herba Epimedii (HE) and Fructus Ligustri Lucidi (FLL) with GC to treat asthma may result in much more efficient treating power, more obviously inhibiting the expression of TGF-β and improving airway remolding in asthma than the single use of GC.…”

Section: Icariinmentioning

confidence: 99%

Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

Yuan

Tong

Dong

et al. 2022

aei

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Bronchial asthma is a common chronic airway disease, and long-term management of asthma is the focus and difficulty of clinical treatment. Glucocorticoids are often used as the first choice for the treatment of asthma. However, the occurrence of hormone dependence, hormone resistance, local and systemic adverse reactions caused by hormone application also brings problems for the treatment of asthma. Finding safe and effective new therapeutic drugs is an important research direction at present. Icariin is the effective ingredient of traditional Chinese medicine Epimedium. It has various biological activities such as anti-inflammatory, anti-oxidative stress, and immune regulation. It has high safety and has a wide range of clinical applications. Icariin has the characteristics of multi-target intervention in the treatment of asthma. This article reviews recent studies in order to provide new research directions for further therapeutic drug development.

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Section: Icariinmentioning

confidence: 99%

Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

Yuan

Tong

Dong

et al. 2022

aei

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“…18 Emerging data suggest that ICA exerts its benecial effects by regulating some biological processes, such as inhibiting inammatory responses and oxidative stress. 19,20 However, it is unclear whether ICA contributes to maintaining or enhancing the intestinal barrier function.…”

Section: Introductionmentioning

confidence: 99%

Icariin enhances intestinal barrier function by inhibiting NF-κB signaling pathways and modulating gut microbiota in a piglet model

Xiong

Zhu

et al. 2019

RSC Adv.

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“…125 Meanwhile, ICA was also controlling the cutaneous hypothalamus-pituitary-adrenal axis to reduce inflammation. 126…”

Section: Mechanisms Of Icariin In Anti-osteoporosismentioning

confidence: 99%

“…125 Meanwhile, ICA was also controlling the cutaneous hypothalamus-pituitary-adrenal axis to reduce inflammation. 126 In mitochondria, ROS are produced, and this ROS production has an effect on harming the cell membrane, cytoplasm, and even DNA. A surplus of ROS encourages osteoclastogenesis and speeds up bone resorption.…”

Section: Icariin Enhances Angiogenesismentioning

confidence: 99%

Icariin: A Potential Alternative Against Osteoporosis

Long

Wang

Lijun

et al. 2022

Natural Product Communications

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Osteoporosis is a metabolic skeletal disorder characterized by increased fragility and fracture risk as s result of reduced bone mineral density and microstructural destruction and caused a heavy burden on families and society. Current medicines, on the other hand, have some limitations, with side effects and doubts regarding long-term efficacy being highlighted. Studies seeking for natural constituents as potential treatment options therefore come into focus. Icariin is a phytochemical derived from a traditional Chinese medicine, Herba epimedium, that has been used to treat orthopedic disorders in ancient China for thousands of years, including osteoporosis, osteoarthritis, and fracture. Icariin belongs to a category of prenylated flavonoids and has been shown to help reduce osteoporosis bone loss while having relatively low side effects. Icariin's anti-osteoporosis properties manifest in a variety of ways, like promoting osteogenesis, suppressing osteoclastogenesis and bone resorption, regulating migration, proliferation, and differentiation of mesenchymal stem cells, enhancing angiogenesis, anti-inflammation, and antioxidation. These procedures entail a slew of critical signaling pathways, such as PPARγ, ERα/AKT/β-catenin, and MAPK. Therefore, icariin can be an applicable alternative to improve osteoporosis although the underlying mechanisms have yet to be fully understood. In this study, we searched using the terms “icariin” and “osteoporosis,” and included 64 articles meeting the inclusion criteria and reviewed the research of icariin in anti-osteoporosis over the last 10 years, and discussed new prospects for future study. Therefore, this review may provide some references for further studies.

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Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus-pituitary-adrenal axis in vitro

Abstract: Icariin has a regulatory effect on steroidogenesis in HaCaT cells, which may provide a promising therapeutic target for the treatment of inflammatory skin disorders.

Cited by 8 publications

References 25 publications

Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

Icariin enhances intestinal barrier function by inhibiting NF-κB signaling pathways and modulating gut microbiota in a piglet model

Icariin: A Potential Alternative Against Osteoporosis

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