Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

Abstract

Bronchial asthma is a common chronic airway disease, and long-term management of asthma is the focus and difficulty of clinical treatment. Glucocorticoids are often used as the first choice for the treatment of asthma. However, the occurrence of hormone dependence, hormone resistance, local and systemic adverse reactions caused by hormone application also brings problems for the treatment of asthma. Finding safe and effective new therapeutic drugs is an important research direction at present. Icariin is the effective ingredient of traditional Chinese medicine Epimedium. It has various biological activities such as anti-inflammatory, anti-oxidative stress, and immune regulation. It has high safety and has a wide range of clinical applications. Icariin has the characteristics of multi-target intervention in the treatment of asthma. This article reviews recent studies in order to provide new research directions for further therapeutic drug development.

Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration

“…Previous studies have demonstrated that ICA can promote osteogenic differentiation 35–37 and inhibit osteoclast differentiation 19,38,39 in the concentration range of 10 −8 –10 −5 M. In addition, ICA has been proven to exert anti-inflammatory activities, and the application of ICA in the treatment of some inflammatory diseases was studied. 40–42 These studies suggested that ICA can modulate the immune response, but the effect of this immunomodulatory function on osseointegration remains unclear.…”

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

“…ICRN (C 33 H 40 O 15 , M w = 676.67) is a type of prenylated flavonoid, showing extensive bioactivities such as antioxidant [ 44 , 45 , 46 , 47 ], neuroprotective [ 48 , 49 , 50 , 51 , 52 ], and antitumor [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] behavior as well as anti-inflammatory responses [ 62 , 63 , 64 , 65 , 66 , 67 , 68 ], and can be used to treat erectile dysfunction [ 69 , 70 , 71 , 72 ]. It appears it can improve the function of organs including bones and the heart [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ].…”

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

“…Icariin (ICA), the main active ingredient in Epimedium genus plants, has a wide range of pharmacological activities [174][175][176]. Studies have shown that ICA inhibits NF-κB activation after IS by upregulating the PPARs/Nrf2 pathway and downregulating the JAK2/STAT3 pathway, thereby enhancing mild hypothermia-induced neuroprotection [127].…”