Ibuprofen crystals with optimized properties

Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer

“…Better wettability of crystals and consequently their easy dispersion in dissolution medium is the main cause of increasing dissolution rate of the drug in presence of stabilizers. 39 However, taking into account this fact that during dissolution tests the agglomerates did not break due to lack of disintegrant, the role of stabilizer in the distribution of crystals could be ruled out. Moreover, the dissolution happens from the agglomerated particle surfaces in direct contact with the dissolution medium as well as from diffusion through the water-filled pores of the agglomerates.…”

Formulation and <i>in vitro</i> evaluation of natural gum-based microbeads for delivery of Ibuprofen

“…In addition, its high cohesiveness which result in poor flowability has made its development quite challenging. Previous studies have shown that ibuprofen is capable of being encapsulated as bead formulations using sodium alginate and other natural polymers such as starch [8]. However, initial burst release which is undesirable for controlled release agents has been reported [8].…”

“…The three natural gums have previously been characterized and found to be useful for controlled delivery of some drugs [9][10][11]. The main focus of the present study was the formulation of microbeads which will avoid the initial burst release which had previously been reported for ibuprofen using sodium alginate and other polymer blends [8]. The ibuprofen microbeads were prepared by the ionotropic gelation technique and the effects of different gum/alginate ratios on the release properties of the microbeads were evaluated.…”

A Review: Meltsonocrystallization Technique Used for Improvement of Solubility

“…The so generated shock waves can cause the particle collide into one another with great force since these are similar charge particles problem of agglomeration is greatly reduced. [43,46,47] There are reports on application of ultrasonic (US) energy during crystallization, i.e.…”