Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer

Maghsoodi, Maryam; Nokhodchi, Ali

doi:10.15171/apb.2016.075

Cited by 12 publications

(18 citation statements)

References 40 publications

(31 reference statements)

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“…So, this is a method to achieve a well‐defined shape and size of the SD aggregates. The method does not require a bridging agent or a mixed solvent in this aggregation process . Rhombic aggregates and rod‐like aggregates were successfully prepared by this method.…”

Section: Resultsmentioning

confidence: 99%

Crystal Structures and Phase Behavior of Sulfadiazine and a Method for the Preparation of Aggregates with Good Performance

Chen

et al. 2018

Chem Eng & Technol

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The solvate and the solvent-free form of sulfadiazine (SD) were investigated. SD was found to exist in one solvent-free form and the N-methylpyrrolidone (NMP) solvate form. The NMP solvate was shown to be a channel-type compound. The intrinsic properties of the solvents were used to evaluate the effects of solubility on the phase transformation of SD and the NMP solvate. The SD phase could transform to the NMP solvate by NMP-mediated phase transformation, which was governed by crystallization of the NMP solvate. The crystalline NMP solvate could transform to the solvent-free solid state through solid-solid transformation upon heating or water penetration-mediated phase transformation. The rate of this water penetration-mediated phase transformation of the NMP solvate to SD was unusually fast. It can be used to obtain SD aggregates of well-defined shape and good powder properties.

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Section: Resultsmentioning

confidence: 99%

Crystal Structures and Phase Behavior of Sulfadiazine and a Method for the Preparation of Aggregates with Good Performance

Chen

et al. 2018

Chem Eng & Technol

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“…When comparing the different solvents, the factors that can strongly influence the nucleation rate are the supersaturation and the change in the interfacial free energy, γ, that appears as the third power in the exponential term. In classical nucleation theory, according to the Gibbs-Thomson equation, interfacial free energy impacts on the nucleation rate J: 20 J = A.exp(-∆Gc) with ∆Gc = 16πγ 3 V 2 0 /3k 3 BT 3 ln(S*) 2 Eqn 1.…”

Section: Discussionmentioning

confidence: 99%

“…The role of solvent is well established in crystallization (for example Mirmehrabi et al 1 ) and the use of anti-solvents is one of the most common crystallization methods in the pharmaceutical industry. 2,3 A key feature of using anti-solvents is that they increase nucleation rates due to a higher driving force (caused by the lower solubility in the anti-solvent). However, the role of solvent other than its role in creating driving force is only little studied.…”

Section: Introductionmentioning

confidence: 99%

Barium sulfate crystallization in non-aqueous solvent

et al. 2021

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“…Drug release was affected by many reasons, such as drug crystallinity, the size and shape of the crystal. 38 According to Fig. 7, it can be concluded that there are still crystals in the SD(HME).…”

Section: Physical Characteristicsmentioning

confidence: 95%

Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point

Zhu

Zhang

et al. 2019

RSC Adv.

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The aim of the study was to develop an amorphous solid dispersion of a poorly water-soluble drug with high melting point by ball milling and hot melt extrusion as a co-processing method. Solid dispersion systems were prepared by ball milling-hot melt extrusion and then compared with those prepared with hot melt extrusion. The effects of three process parameters in the co-processing method, namely, barrel temperature, screw speed, and cooling rate, were systematically studied. The physical state of prepared solid dispersion was characterized by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, phase solubility, and dissolution study.The Resveratrol-Eudragit® EPO system exhibited good miscibility and significant dissolution enhancement. Resveratrol in the amorphous solid dispersion existed in an amorphous state and had molecular interactions with Eudragit® EPO. Stability studies showed no apparent difference in the physical state of the solid dispersion after 6 months. In conclusion, combining ball milling with hot melt extrusion is a promising method for preparing the amorphous solid dispersion of a poorly water-soluble drug with high melting point. Fig. 6 The dissolution curves of RES from solid dispersions under different parameters: (a) ball milling time, (b) ball milling frequency, (c) barrel temperature, (d) screw speed, (e) cooling rate.

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Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer

Cited by 12 publications

References 40 publications

Crystal Structures and Phase Behavior of Sulfadiazine and a Method for the Preparation of Aggregates with Good Performance

Crystal Structures and Phase Behavior of Sulfadiazine and a Method for the Preparation of Aggregates with Good Performance

Barium sulfate crystallization in non-aqueous solvent

Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point

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