Formulation and &lt;i&gt;in vitro&lt;/i&gt; evaluation of natural gum-based microbeads for delivery of Ibuprofen

Odeku, Oluwatoyin A.; Okunlola, Adenike; Lamprecht, Alf

doi:10.4314/tjpr.v13i10.2

Cited by 14 publications

(11 citation statements)

References 17 publications

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“…This indicates that drug release from the microbeads was controlled by a combination of diffusion and erosion mechanisms. This is consistent with previous reports on release kinetics of diclofenac and ibuprofen microbeads prepared using sodium alginate and some natural polymers [12,13].…”

Section: Physicochemical and Drug Release Properties Of Microbeadssupporting

confidence: 94%

“…Furthermore, they form microbeads, which have cracked and porous surfaces that can lead to relatively fast diffusion of moisture and other fluids, thus reducing the barrier properties in unfavorable environmental conditions [10]. Blending alginate with natural polymers such as gums and starches is a recent innovation that has been shown to be effective in overcoming many of these limitations by enhancing encapsulation efficiency and drug release properties of microbeads [4,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

Okunlola

Odeku

Lamprecht

et al. 2015

International Journal of Biological Macromolecules

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Section: Physicochemical and Drug Release Properties Of Microbeadssupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

Okunlola

Odeku

Lamprecht

et al. 2015

International Journal of Biological Macromolecules

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“…23-27 The release pattern of the theophylline microbead formulations showed that Batches B 7 and B 8 (sodium alginate alone) as well as B 1 , B 4 and B 6 had an initial burst release as observed from the short period of t 15 (<60 minutes). 23,28,29 This was followed by slow release of the drug. Microbeads with smaller sizes released a higher percentage of the drug which may be due to their larger surface areas.…”

Section: Resultsmentioning

confidence: 99%

Development of Theophylline Microbeads Using PregelatinizedBreadfruit Starch (Artocarpus altilis) as a Novel Co-polymer for Controlled Release

Okunlola

Adewusi

2019

Adv Pharm Bull

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Purpose: The aim of this study was to prepare formulations of theophylline microbeads usingpregelatinized breadfruit starch (Artocarpus altilis, family Moraceae) in combination withsodium alginate and chitosan at various polymer: drug ratios. Microbead formulations forcontrolled delivery of theophylline would be better alternatives to conventional dosage formsfor optimized drug therapy.Methods: The native and pregelatinized starches were characterized for morphology (scanningelectron microscope), crystallinity (Fourier transform intra-red spectroscopy, FTIR and X-raydiffractometer, XRD), thermal flow (differential scanning colorimeter), density and flowproperties. Theophylline microbeads were prepared by ionic gelation and characterized usingsize, swelling index, entrapment efficiency and time required for 15% and 50% drug release (t15and t50 respectively).Results: FTIR and XRD spectra revealed the orderly arrangement of granules of the semi-crystallinebreadfruit starch was disrupted on gelatinization. The viscosity and flow of pregelatinized starchwere enhanced. Theophylline microbeads were near spherical in shape with size range 1.09± 0.672 to 1.58 ± 0.54 mm. FTIR and XRD spectra confirmed there was no drug-polymerinteraction. Microsphere size, swelling increased while entrapment and dissolution time (t50)reduced with polymer: drug ratio. The entrapment efficiency ranged from 30.99 ± 1.32 to 78.50± 2.37%. Optimized formulation, starch: alginate ratio 3:1 at polymer: drug ratio of 2:1, gave aprolonged dissolution time (t50 = 8.40 ± 1.20 h).Conclusion: Breadfruit starch was suitable as a copolymer for the controlled delivery oftheophylline in microbeads which could serve as a substitute to synthetic polymers in drugdelivery.

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“…5-FU containing FSM-SA microbeads were developed using the conventional ionotropic gelation method with a slight modification [35] . Weighed quantity of FSM (1, 2 and 3 ratio to SA) in 20 ml distilled water heated at 80° on water bath for 20 min with occasional stirring.…”

Section: Preparation Of Micro Beads Containing 5-fumentioning

confidence: 99%

Development and Characterization of Colon-targeting 5-Fluorouracil Multiparticulate Beads

Sarangi¹,

Rao²,

Parcha³

et al. 2020

Indian J Pharm Sci

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This investigation is related to the development and optimization of multiparticulate beads of fenugreek seed mucilage-sodium alginate containing 5-flurouracil through ionotropic gelation technique using 3 2 full factorial design generated with Design-Expert® Version11 software. The beads were developed using CaCl 2 as the crosslinking agent. The effect of ratio of fenugreek seed mucilage and sodium alginate blend and concentration of CaCl 2 on the drug encapsulation efficiency, bead size and percent cumulative drug release in 6 h was optimized by 3 2 factorial design. The beads were also characterized using field emission scanning electron microscopy, Fourier-transform infrared spectroscopy and thermal analysis. The percent drug encapsulation efficiency of all these beads was within the range of 43.91 to 85.39 % with an in vitro drug release of 33.92 to 39.23 % in 6 h. The optimized batches of beads were coated with Eudragit S100 (5, 10 and 15 % w/v) to facilitate colon targeting in a prominent way. The in vitro drug release from the coated beads (P3) in various colonic fluids followed zero-order pattern with erosion mechanism in 18 h. The average size of these beads was within the range of 895 to 1021 µm. The optimized fenugreek seed mucilage-alginate beads containing 5-flurouracil showed significant drug permeability over a prolonged period in an ex vivo permeability study through goat colon. The results indicated successful colon targeting of 5-flurouracil multiparticulate beads developed using polymeric blends containing sodium alginate and fenugreek seed mucilage in an appropriate ratio.

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Formulation and <i>in vitro</i> evaluation of natural gum-based microbeads for delivery of Ibuprofen

Cited by 14 publications

References 17 publications

Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

Development of Theophylline Microbeads Using PregelatinizedBreadfruit Starch (Artocarpus altilis) as a Novel Co-polymer for Controlled Release

Development and Characterization of Colon-targeting 5-Fluorouracil Multiparticulate Beads

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