Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

Formulation Development and Evaluation of Sustained Release Ranolazine Microbeads using Natural Polymer

“…Mix both resultant viscous solution with each other and drug was incorporated into the polymer solutions and it was placed on a magnetic stirrer at 35°C and at 600 rpm for about 30 minutes. Now, the drug-containing polymer solution formed above was poured drop by drop through 23 gauze needles into another beaker containing calcium chloride solution (2%w/v) with continuous magnetic stirring at 300 rpm for 30 min 15,19 . The formed microbeads were filtered, cleaned with distilled water, and were dried in a hot air oven at 40°C for 24 hours 29 .…”

“…Kokilaksha seed mucilage is a hydrophilic polysaccharide that swells in hot water. Herbal mucilage and sodium alginate have been characterized and used to form microbeads using calcium chloride as a chelating agent by an ionic gelation method 19 . Angina pectoris is a condition characterized by significant chest discomfort caused by a lack of blood supply to the heart.…”

Iron deficiency anemia (ida) and iron deficiency (id): are alginates a good choise to improve oral iron bioavailability and safety?

“…Recently, ALG microsphere with Ranitidine obtained by spraydrying techniques have shown to improve Ranitidine oral iron bioavaiability [12] confirming that ALG co-processed with other substances by spray-drying technique could represent an innovative and cost-effective method to improve oral bioavailability and to reduce gastrointestinal drug's side effects [12]. Zein-Alginate based oral drug delivery system have demostrated to protect Superoxide Dismutase (SOD) from the harsh conditions of gastrointestinal tract [13] and cissus-gum employed as polymer with sodium alginate in the formulation of diclofenac microbeds have shown to reduce gastric side effects of diclofenac in rats [14].…”