<i>Tmevpg1</i>, a Candidate Gene for the Control of Theiler's Virus Persistence, Could Be Implicated in the Regulation of Gamma Interferon

Vigneau, Soline; Rohrlich, Pierre‐Simon; Brahic, Michel; Bureau, Jean‐François

doi:10.1128/jvi.77.10.5632-5638.2003

Cited by 155 publications

(154 citation statements)

References 39 publications

(25 reference statements)

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“…33 NeST, formerly known as Tmevpg1, is located close to the IFN-g gene on chromosome 10 of the mouse genome; a locus previously demonstrated by genetic mapping to be closely linked with susceptibility to Theiler's virus-induced neurological and inflammatory diseases. 35,36 NeST had long been suspected to be involved in regulation IFN-g expression, 37 but the mechanism was not known. Gomez et al showed that NeST acts in trans to increase IFN-g expression by interaction with the WDR5/MLL adaptor protein and alteration of H3K3 methylation at the IFN-g promoter.…”

Section: Lncrnas Are Novel Regulators Of Innate Immunitymentioning

confidence: 99%

Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

Li¹,

Rana

2014

RNA Biology

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Section: Lncrnas Are Novel Regulators Of Innate Immunitymentioning

confidence: 99%

Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

Li¹,

Rana

2014

RNA Biology

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“…The spinal cord was dissected out and stored at -80°. Total RNAs were extracted using TRI-REAGENT (Molecular Research Center, Cincinnati) and reverse transcribed as previously described (Vigneau et al 2003). Hprt amplification was used to normalize the efficiency of the reverse transcription.…”

Section: B10smentioning

confidence: 99%

Interleukin 22 Is a Candidate Gene forTmevp3, a Locus Controlling Theiler's Virus-Induced Neurological Diseases

Levillayer

Mas²,

Levi‐Acobas

et al. 2007

Genetics

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After intracerebral inoculation, Theiler's virus induces in its natural host, the mouse, an acute encephalomyelitis followed, in susceptible animals, by chronic inflammation and primary demyelination. Susceptibility to demyelination among strains of laboratory mice is explained by the capacity of the immune system to control viral load during persistence. Also, differences of susceptibility to viral load between the susceptible SJL strain and the resistant B10.S strain are mainly due to two loci, Tmevp2 and Tmevp3, located close to the Ifng locus on chromosome 10. In this article, we show that the Tmevp3 locus controls both mortality during the acute encephalomyelitis and viral load during persistence. Most probably, two genes located in the Tmevp3 interval control these two different phenotypes with efficiencies that depend on the age of the mouse at inoculation. Il22, a member of the IL-10 cytokine family, is a candidate gene for the control of mortality during the acute encephalomyelitis.

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“…A ncRNA, Tmevpg1, identified in human and mouse CD8 ϩ T cells, has been shown to be located within a cluster of cytokine genes in the genome and was initially suggested to control viral load during persistent infection of the CNS (12). However, its precise role remains unknown.…”

Section: Ytotoxic Cd8mentioning

confidence: 99%

Genome-Wide Identification of Long Noncoding RNAs in CD8+ T Cells

Pang

Dinger²,

Mercer³

et al. 2009

The Journal of Immunology

211

191

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Previous research into the molecular mechanisms that underlie Ag-specific CD8؉ T cell differentiation and function has largely focused on the role of proteins. However, it is now apparent that the mammalian genome expresses large numbers of long (>200 nt) nonprotein-coding RNAs (ncRNAs), and there is increasing evidence that these RNAs have important regulatory functions, particularly in the regulation of epigenetic processes underpinning cell differentiation. In this study, we show that CD8 ؉ T cells express hundreds of long ncRNAs, many of which are lymphoid-specific and/or change dynamically with lymphocyte differentiation or activation. Numerous ncRNAs surround or overlap immunologically important protein-coding genes and can be predicted to function via a range of regulatory mechanisms. The overlap of many long ncRNAs expressed in CD8 ؉ T cells with microRNAs and small interfering RNAs further suggests that long ncRNAs may be processed into and exert their effects via smaller functional species. Finally, we show that the majority of long ncRNAs expressed in CD8 ؉ T cells harbor signatures of evolutionary conservation, secondary structures, and/or regulated promoters, further supporting their functionality. Taken together, our findings represent the first systematic discovery of long ncRNAs expressed in CD8؉ T cells and suggest that many of these transcripts are likely to play a role in adaptive immunity. The Journal of Immunology, 2009, 182: 7738 -7748. C ytotoxic CD8ϩ T cells represent a critical arm of the adaptive immune system. They originate from common lymphoid precursors in the bone marrow and undergo subsequent selection in the thymus. Following viral infection, naive CD8 ϩ T cells develop into effector cells that, upon activation, kill infected host cells and limit viral spread. Once an infection is cleared, most CD8 ϩ T cells undergo programmed cell death, leaving behind a minority of self-renewable memory CD8 ϩ T cells that are able to rapidly mount a protective response upon subsequent viral challenge. Intensive study over the past few decades has considerably advanced our knowledge of the functional and phenotypic changes that occur throughout the CD8 ϩ T cell life cycle. Nevertheless, our knowledge of the underlying regulatory basis for CD8 ϩ T cell differentiation and function remains incomplete. In the past decade, it has become increasingly evident that nonprotein-coding RNAs (ncRNAs) 4 fulfill critical regulatory roles in mammalian biology. Most attention has focused on short RNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs, which regulate gene expression at the transcriptional and/or posttranscriptional levels (reviewed in Refs. 1 and 2). Although less prominent, long ncRNAs (Ͼ200nt) have also been recognized as serving important biological functions (reviewed in Ref.3). Air and HOTAIR, for instance, coordinate and regulate gene expression within the Igf2r and HOX loci, respectively, whereas Xist does so across an entire chromosome (4 -6). In ...

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Tmevpg1, a Candidate Gene for the Control of Theiler's Virus Persistence, Could Be Implicated in the Regulation of Gamma Interferon

Cited by 155 publications

References 39 publications

Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

Interleukin 22 Is a Candidate Gene forTmevp3, a Locus Controlling Theiler's Virus-Induced Neurological Diseases

Genome-Wide Identification of Long Noncoding RNAs in CD8+ T Cells

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