Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

Li, Zhonghan; Rana, Tariq M.

doi:10.4161/rna.29937

Cited by 42 publications

(32 citation statements)

References 54 publications

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“…Over the last two decades, accumulating evidence indicates that lncRNAs might modulate the innate immune response . More and more lncRNAs were determined, such as lnc‐interleukin 7 receptor , nonprotein coding RNA repressor of NFAT (NRON) , and many more, representing a new series of molecules that is associated with the gene expressions and functions of immune cells . Recently, lncRNAs have key functions in ward off MTB invasion.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of long noncoding RNA RP11‐37B2.1 associate with susceptibility of tuberculosis and adverse events of antituberculosis drugs in west China

Song

Liu

Zhao

et al. 2019

Clinical Laboratory Analysis

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BackgroundLittle knowledge about the biological functions of RP11‐37B2.1, a newly defined long noncoding RNA (lncRNA) molecule, is currently available. Previous studies have shown rs160441, located in the RP11‐37B2.1 gene, is significantly associated with tuberculosis (TB) in a Ghanaian and the Gambian populations.MethodsWe investigated the influence of single‐nucleotide polymorphisms (SNPs) within lncRNA RP11‐37B2.1 on the risk of TB and the possible correlation with adverse drug reactions (ADRs) from TB treatment in a Western Chinese population. Four SNPs within lncRNA RP11‐37B2.1 were genotyped in 554 TB cases and 561 healthy subjects using the improved multiplex ligation detection reaction method, and the patients were followed up monthly to monitor the development of ADRs.ResultsNo significant association between the SNPs of lncRNA RP11‐37B2.1 and TB susceptibility was observed (all P > 0.05). Surprisingly, significant association was observed between two SNPs (rs218916 and rs160441) and thrombocytopenia development during anti‐TB therapy under the dominant model (P = 0.003 and 0.014, respectively).ConclusionsOur findings firstly exhibit that rs218916 and rs160441 within lncRNA RP11‐37B2.1 significantly associate with the occurrence of thrombocytopenia and suggest RP11‐37B2.1 genetic variants are potential biosignatures for thrombocytopenia during anti‐TB treatment.

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of long noncoding RNA RP11‐37B2.1 associate with susceptibility of tuberculosis and adverse events of antituberculosis drugs in west China

Song

Liu

Zhao

et al. 2019

Clinical Laboratory Analysis

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“…38,39 NF-kB pathway is the central mediator and a key participant of the inflammatory processes. 40 NF-kB is also a converged molecule acting as both a responder and regulator of the inflammatory factors linked to endothelial activation and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway

et al. 2015

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Antisense Noncoding RNA in the INK4 Locus (ANRIL) is the prime candidate gene at Chr9p21, the welldefined genetic risk locus associated with multiple human diseases including coronary artery disease (CAD), while little is known regarding its role in the pathological processes. Endothelial dysfunction triggers atherosclerotic processes that are causatively linked to CAD. To evaluate the function of ANRIL in human endothelial cells (ECs), we examined ANRIL expression under pathological stimuli and found ANRIL was markedly induced by pro-inflammatory factors. Loss-of-function and chromatin immunoprecipitation approaches revealed that NF-kB mediates TNF-a induced ANRIL expression. RNA sequencing revealed that ANRIL silencing dysregulated expression of inflammatory genes including IL6 and IL8 under TNF-a treatment. We explored the regulatory mechanism of ANRIL on IL6/8 and found that Yin Yang 1 (YY1), an ANRIL binding transcriptional factor revealed by RNA immunoprecipitation, was required for IL6/8 expression under TNF-a treatment. YY1 was enriched at promoter loci of IL6/8 and ANRIL silencing impaired the enrichment, indicating a cooperation between ANRIL and YY1 in the regulation of inflammatory genes. For the first time, we establish the connection between ANRIL and NF-kB pathway and show that ANRIL regulates inflammatory responses through binding with YY1. The newly identified TNF-a-NF-kB-ANRIL/YY1-IL6/8 pathway enhances understanding of the etiology of CAD and provides potential therapeutic target for treatment of CAD.

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“…An example of such a mode of action is the functional interaction and cooperation between the lncRNA HOTTIP and the MLL complex subunit WDR5 [50]. …”

Section: Roles Of Lncrnas In Cancermentioning

confidence: 99%

Dysregulated expression of long noncoding RNAs in gynecologic cancers

et al. 2017

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Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system. LncRNAs play a critical physiological role in apoptosis, metastasis, invasion, migration and cell proliferation in these cancers. Different expression profiles of lncRNAs have been observed in various types of tumors compared with normal tissues and between malignant and benign tumors. These differential expression patterns may lead to the promotion or suppression of cancer development and tumorigenesis. In the current review, we present the lncRNAs that show a differential expression between cancerous and normal tissues in ovarian, cervical and endometrial cancers, and highlight the associations between lncRNAs and some of the molecular pathways involved in these cancers.

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Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

Cited by 42 publications

References 54 publications

Genetic polymorphisms of long noncoding RNA RP11‐37B2.1 associate with susceptibility of tuberculosis and adverse events of antituberculosis drugs in west China

Genetic polymorphisms of long noncoding RNA RP11‐37B2.1 associate with susceptibility of tuberculosis and adverse events of antituberculosis drugs in west China

Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway

Dysregulated expression of long noncoding RNAs in gynecologic cancers

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