<i>Thymus atlanticus</i> polyphenol-rich extract regulates cholesterol metabolism by inhibiting its biosynthesis without affecting its excretion in hamsters fed a high-fat diet

Ramchoun, Mhamed; Khouya, Tarik; Alibrahim, E. Alabed; Hmidani, Abdelbassat; Sellam, Khalid; Amrani, Souliman; Harnafi, Hicham; Benlyas, Mohamed; Chadli, Fatima Kasbi; Ouguerram, Khadija; Alem, Chakib

doi:10.1080/13813455.2020.1854308

Cited by 11 publications

(10 citation statements)

References 31 publications

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“…atlanticus has been found to decrease serum cholesterol by downregulating HMG reductase and to decrease liver and plasma TG in hamsters feeding on HFD (Ramchoun, Khouya, Alibrahim, Hmidani, et al, 2020). The inhibitory effect of T. atlanticus on cholesterol biosynthesis and its antihypertriglyceridemia effect could explain the decrease in LDL-C level and ameliorated lipoprotein profile observed in this study.…”

Section: Groupssupporting

confidence: 60%

“…This is consistent with available studies, which have shown that extracts of T. atlanticus ameliorated chronic hyperlipidemia in HFD‐fed mice and alleviated the alteration in the lipoprotein profile induced by Triton in golden hamsters (Ramchoun, Khouya, Harnafi, Alem, et al, 2020; Ramchoun, Khouya, Harnafi, Amrani, et al, 2020). The Pp of T. atlanticus has been found to decrease serum cholesterol by downregulating HMG reductase and to decrease liver and plasma TG in hamsters feeding on HFD (Ramchoun, Khouya, Alibrahim, Hmidani, et al, 2020). The inhibitory effect of T. atlanticus on cholesterol biosynthesis and its antihypertriglyceridemia effect could explain the decrease in LDL‐C level and ameliorated lipoprotein profile observed in this study.…”

Section: Discussionmentioning

confidence: 99%

“…After the treatment, hamsters were fasted for 18 h and the blood samples were collected in heparinized tubes after retro‐orbital puncture under slight isoflurane anesthesia to determine glycemic parameters, lipoprotein profile, and the activity of serum antioxidant enzymes. The used dose of plant extract and the period of study were chosen based on previous studies (Ramchoun, Khouya, Alibrahim, Hmidani, et al, 2020; Ramchoun, Khouya, Harnafi, Amrani, et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, Pp administration reduced plasma cholesterol and LDL‐C and both plasma and liver TG in hyperlipidemic animals and, in some cases, produced a slight but significant elevation in HDL cholesterol (HDL‐C) (Ramchoun et al, 2012, Ramchoun, Khouya, Harnafi, Alem, et al, 2020, Ramchoun, Khouya, Harnafi, Amrani, et al, 2020). A potential mechanism of the lipid‐lowering effect of Pp is the inhibition of cholesterol biosynthesis by downregulating 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase expression without affecting cholesterol exertion (Ramchoun, Khouya, Alibrahim, Hmidani, et al, 2020). Crude aqueous and organic extracts have shown potent antioxidant activities in many studies in vitro (Hmidani et al, 2019; Khouya et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Effect of supplementation with polyphenol extract of Thymus atlanticus on paraoxonase‐1 activity, insulin resistance, and lipid profile in high‐fat diet‐fed hamsters

Khouya

Ramchoun

Hmidani

et al. 2022

Journal of Food Biochemistry

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The consumption of high-fat diets is associated with oxidative stress and metabolic disorders, such as hyperlipidemia and insulin resistance (Duan et al., 2018). Hyperlipidemia causes oxidative stress as a consequence of increased reactive oxygen species (ROS) production during mitochondrial fatty acid β-oxidation (Lian et al., 2020). Most studies have reported that oxidative conditions are associated with several diseases and, together with hyperlipidemia, constitute two major factors involved in atherosclerosis and cardiovascular complications, such as stroke and coronary heart disease (Sies et al., 2017).Increased plasma lipid levels harm glucose metabolism and lead to

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Section: Groupssupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of supplementation with polyphenol extract of Thymus atlanticus on paraoxonase‐1 activity, insulin resistance, and lipid profile in high‐fat diet‐fed hamsters

Khouya

Ramchoun

Hmidani

et al. 2022

Journal of Food Biochemistry

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“…Polyphenol extracts were obtained from T. atlanticus and T. willdenowii aerial parts, as described by Ramchoun et al (2020). Fifty grams of air-dried plant powder was put in a Soxhlet apparatus and defatted with n-hexane until the eluent become colorless.…”

Section: Plant Materials and Extractionmentioning

confidence: 99%

In vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extracts

Elbouny

Ouahzizi

Sellam

et al. 2023

International Journal of Secondary Metabolite

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Thyme species produce a wide variety of phenolic compounds including tannins, phenolic acids, and flavonoids. Thymus atlanticus (T. atlanticus) and Thymus willdenowii (T. willdenowii) are important thyme species in the southeast of Morocco, with numerous biological properties. The polyphenolic extracts of these two thyme species were obtained using ethanol through Soxhlet apparatus. Antioxidant (DPPH, FRAP, and TAC methods), antihemolytic (2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) induced hemolysis test), hypolipidemic (3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity inhibition test), and anti-inflammatory (protein denaturation inhibition) effects of extracts were carried out using in vitro methods. The results showed that the polyphenolic extracts of these two species revealed important amounts of phenolic compounds. The contents of flavonoids were significant in the two species, while the contents of tannins and anthocyanin were very low. T. atlanticus showed an important antioxidant activity and a considerable antihemolytic effect in AAPH-induced hemolysis test (IC50 = 0.29 mg/mL), while T. willdenowii showed an important anti-inflammatory activity in heat-induced protein denaturation test (IC50 = 1.61 mg/mL). Moreover, both extracts at a dose of 20 µg/mL showed an important in vitro hypolipidemic activity by inhibiting HMG-CoA reductase activity (T. willdenowii: 51.16 %; T. atlanticus: 62.83 %). In conclusion, T. willdenowii and T. atlanticus extracts have considerable antioxidant, antihemolytic, hypolipidemic, and anti-inflammatory effects. The richness of these species in polyphenols gives them a large specter of biological properties, making them a valuable source of natural bioactive compounds that could prevent or treat various diseases.

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Loquat (Eriobotrya japonica (Thunb) Lindl.): Evaluation of nutritional value, polyphenol composition, antidiabetic effect, and toxicity of leaf aqueous extract

Khouya

Ramchoun

Elbouny

et al. 2022

Journal of Ethnopharmacology

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Thymus atlanticus polyphenol-rich extract regulates cholesterol metabolism by inhibiting its biosynthesis without affecting its excretion in hamsters fed a high-fat diet

Cited by 11 publications

References 31 publications

Effect of supplementation with polyphenol extract of Thymus atlanticus on paraoxonase‐1 activity, insulin resistance, and lipid profile in high‐fat diet‐fed hamsters

Effect of supplementation with polyphenol extract of Thymus atlanticus on paraoxonase‐1 activity, insulin resistance, and lipid profile in high‐fat diet‐fed hamsters

In vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extracts

Loquat (Eriobotrya japonica (Thunb) Lindl.): Evaluation of nutritional value, polyphenol composition, antidiabetic effect, and toxicity of leaf aqueous extract

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