<i>Staphylococcus aureus</i> induces COX-2-dependent proliferation and malignant transformation in oral keratinocytes

Wang, Yuxia; Liu, Shiyu; Li, Bolei; Jiang, Yaling; Zhou, Xinxuan; Chen, Jing; Li, Mingyun; Ren, Biao; Peng, Xian; Zhou, Xuedong; Cheng, Lei

doi:10.1080/20002297.2019.1643205

Cited by 22 publications

(14 citation statements)

References 55 publications

(57 reference statements)

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“…Another recent study has shown that infection of HOK cells with S. aureus can facilitate increased cell proliferation through upregulation of COX2 and a concomitant increase in cyclin D1 with a suppression of p16. These changes resulted in colony formation growth as a measure of malignancy [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

E-Cigarette Aerosols Promote Oral S. aureus Colonization by Delaying an Immune Response and Bacterial Clearing

Catala-Valentin

Almeda

Bernard

et al. 2022

Cells

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E-cigarette (e-cig) vapor has been shown to play a pathological role in oral health and alter the oral microbiota, providing growth advantages for opportunistic pathogens. Enrichment of Staphylococcus aureus, a commensal resident in the oral cavity, correlates with the progression of periodontal disease, suggesting a role as an opportunistic pathogen. Environmental conditions, such as cigarette smoke, are known to increase S. aureus virulence, yet the role of S. aureus in periodontitis and oral preneoplasia is unknown. We exposed oral epithelial cells to e-cig aerosols and showed a dose-dependent cell viability reduction, regardless of nicotine content, in a possible attempt to repair DNA damage, as measured by pH2AX. S. aureus attachment to oral epithelial cells and bacterial biofilm formation were enhanced upon e-cig exposure, indicating an increased capacity for oral colonization. Mechanistically, e-cig aerosol exposure resulted in an immunosuppression, as determined by a reduction in IL8, IL6, and IL1β secretion by oral epithelial cells during co-culture with S. aureus. Consistent with this, e-cig vape reduced the oral epithelial cell clearance of S. aureus. Furthermore, we observed an increased expression of the inflammatory regulator COX2. This work suggests that e-cigs promote S. aureus colonization and modulate the oral inflammatory response, possibly promoting oral periodontitis and preneoplasia.

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Section: Discussionmentioning

confidence: 99%

E-Cigarette Aerosols Promote Oral S. aureus Colonization by Delaying an Immune Response and Bacterial Clearing

Catala-Valentin

Almeda

Bernard

et al. 2022

Cells

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“…Inflammation affects the occurrence and development of cancer through different pathways. 32 , 33 As evidence has accumulated linking inflammation with cancer development, additional indicators of cancer-related inflammation have been discovered. Cancer patients with higher SII or lower LCR or LCS have significantly worse prognoses than those with lower SII or higher LCR or LCS.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Roles of Inflammation- and Nutrition-Based Indicators for Female Patients with Cancer

Yang¹,

Zhang²,

Ge³

et al. 2022

JIR

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Purpose The incidence, progression, and prognosis of cancer could be affected by inflammation and nutrition. Female patients have different inflammatory and nutritional states depending on their age and tumor types. It is important to screen for suitable prognostic indicators in female patients with cancer of different ages and tumor types. Patients and Methods Baseline clinicopathologic and laboratory characteristics of 1502 female patients with cancer were obtained from a multicenter cohort study. Concordance indices (C-indices) were used to evaluate the prediction accuracy of following inflammation- and nutrition-based indicators: advanced lung cancer inflammation index (ALI), systemic immune inflammation index (SII), modified geriatric nutritional risk index (mGNRI), albumin-to-globulin ratio (AGR), prognostic nutritional index (PNI), lymphocyte-to-C-reactive protein ratio (LCR), controlling nutritional status score (CONUT), modified Glasgow prognostic score (mGPS), and lymphocyte-to-C-reactive protein score (LCS). Results The most suitable indicators in different female populations with cancer had C-indices as follows: LCR (0.668; 95% CI, 0.644–0.693) for all females; AGR (0.681; 95% CI, 0.619–0.743) for young females; LCR (0.667; 95% CI, 0.628–0.706) for middle-aged females; ALI (0.597; 95% CI, 0.574–0.620) for elderly females; LCR (0.684; 95% CI, 0.621–0.747) for females with reproductive system cancer; and ALI (0.652; 95% CI, 0.624–0.680) for females with non-reproductive system cancer. Conclusion The most suitable indicators for the different female populations with cancer are summarized as follows: LCR for all females, AGR for young females, LCR for middle-aged females, ALI for elderly females, LCR for females with reproductive system cancer, and ALI for females with non-reproductive system cancer.

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“…In addition, inflammatory cytokines were produced by the activated macrophages (Xavier & Podolsky, 2007). In oral keratinocytes, Staphylococcus spp., especially S. aureus , could induce infection‐associated malignant transformation of oral epitheliums via Cox2 activation (Wang et al., 2019). Staphylococcus aureus can also upregulate Cox2 expression and prostaglandin E2 ( Pge2 ) secretion in human aortic endothelial cells and induce Pge2 /interleukin 6 ( Il‐6 )/matrix metallopeptidase‐9‐dependent cell migration (Tsai et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Zeolite‐containing mixture alleviates microbial dysbiosis in dextran sodium sulfate‐induced colitis in mice

Lyu

Jia

Deng

et al. 2020

Food Science & Nutrition

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Inflammatory bowel disease (IBD) is a multifactorial immunomodulatory disorder. In relative nosogenesis, gut microbiota has been the focus of research on IBD. In our previous study, we demonstrated the ameliorating effect of zeolite‐containing mixture (Hydryeast®, HY) on dextran sodium sulfate (DSS)‐induced colitis, through transcriptomics and proteomics. In the present study, we performed further investigation from the perspective of metagenomics using the gut microbiota. C57BL6 mice were provided an AIN‐93G basal diet or a 0.8% HY‐containing diet, and sterilized tap water for 11 days. Thereafter, colitis was induced by providing 1.5% (w/v) DSS‐containing water for 9 days. DNA was extracted from the cecal contents and pooled into libraries in a single Illumina MiSeq run. The resulting sequences were analyzed using Quantitative Insights Into Microbial Ecology (QIIME) software. According to the alterations in the relative abundance of certain bacteria, and the related gene and protein expressions, HY supplementation could improve the gut microbiota composition, ameliorate the degree of inflammation, inhibit the colonic mucosal microbial growth, and, to some extent, promote energy metabolism in the colon compared with the DSS treatment. Thus, we believe that HY may be a candidate to prevent and treat IBD.

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Staphylococcus aureus induces COX-2-dependent proliferation and malignant transformation in oral keratinocytes

Cited by 22 publications

References 55 publications

E-Cigarette Aerosols Promote Oral S. aureus Colonization by Delaying an Immune Response and Bacterial Clearing

E-Cigarette Aerosols Promote Oral S. aureus Colonization by Delaying an Immune Response and Bacterial Clearing

Prognostic Roles of Inflammation- and Nutrition-Based Indicators for Female Patients with Cancer

Zeolite‐containing mixture alleviates microbial dysbiosis in dextran sodium sulfate‐induced colitis in mice

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