<i>Spirulina</i>-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism

Jung, Sang-Myung; Min, Seul Ki; Lee, Hoo Chul; Kwon, Yeo Seon; Jung, Moon Hee; Shin, Hwa Sung

doi:10.1155/2016/6135727

Cited by 36 publications

(24 citation statements)

References 40 publications

(37 reference statements)

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“…Spirulina extract-loaded PCL nanofiber wound dressings have been found to increase the fibroblast viability in vitro by suppressing the function of ROS. In vivo assays carried out using these nanofibers have showed increased rate of wound healing and skin regeneration [40] .…”

Section: Introductionmentioning

confidence: 99%

Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application

Rather

Thakore

Singh

et al. 2018

Bioactive Materials

165

117

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Skin wound healing involves a coordinated cellular response to achieve complete reepithelialisation. Elevated levels of reactive oxygen species (ROS) in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing process. Cerium oxide nanoparticles (CeNPs) have the ability to protect the cells from oxidative damage by actively scavenging the ROS. Furthermore, matrices like nanofibers have also been explored for enhancing wound healing. In the current study CeNP functionalised polycaprolactone (PCL)-gelatin nanofiber (PGNPNF) mesh was fabricated by electrospinning and evaluated for its antioxidative potential. Wide angle XRD analysis of randomly oriented nanofibers revealed ∼2.6 times reduced crystallinity than pristine PCL which aided in rapid degradation of nanofibers and release of CeNP. However, bioactive composite made between nanoparticles and PCL-gelatin maintained the fibrous morphology of PGNPNF upto 14 days. The PGNPNF mesh exhibited a superoxide dismutase (SOD) mimetic activity due to the incorporated CeNPs. The PGNPNF mesh enhanced proliferation of 3T3-L1 cells by ∼48% as confirmed by alamar blue assay and SEM micrographs of cells grown on the nanofibrous mesh. Furthermore, the PGNPNF mesh scavenged ROS, which was measured by relative DCF intensity and fluorescence microscopy; and subsequently increased the viability and proliferation of cells by three folds as it alleviated the oxidative stress. Overall, the results of this study suggest the potential of CeNP functionalised PCL-gelatin nanofibrous mesh for wound healing applications.

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Section: Introductionmentioning

confidence: 99%

Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application

Rather

Thakore

Singh

et al. 2018

Bioactive Materials

165

117

View full text Add to dashboard Cite

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“…SM1127 EPS has an excellent moisture-retention ability, which is better than that of the functional biopolymers generally used in wound dressings, such as HA, chitosan, and sodium alginate [24], and thus can provide cells a moist environment to favor cell migration and wound healing [33]. In addition, infection and inflammation of wounds usually cause the generation of an excess of reactive oxygen species (ROS), which destroy DNA structure, oxidize proteins and lipids, and hinder wound healing [34]. SM1127 EPS has a good antioxidant activity for scavenging DPPH•, •OH, O2 − • [24], which may help in reducing the ROS level during tissue regeneration and, therefore, improve wound healing.…”

Section: Discussionmentioning

confidence: 99%

Promotion of Wound Healing and Prevention of Frostbite Injury in Rat Skin by Exopolysaccharide from the Arctic Marine Bacterium Polaribacter sp. SM1127

et al. 2020

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Many marine microorganisms synthesize exopolysaccharides (EPSs), and some of these EPSs have been reported to have potential in different fields. However, the pharmaceutical potentials of marine EPSs are rarely reported. The EPS secreted by the Artic marine bacterium Polaribacter sp. SM1127 has good antioxidant activity, outstanding moisture-retention ability, and considerable protective property on human dermal fibroblasts (HDFs) at low temperature. Here, the effects of SM1127 EPS on skin wound healing and frostbite injury prevention were studied. Scratch wound assay showed that SM1127 EPS could stimulate the migration of HDFs. In the full-thickness cutaneous wound experiment of Sprague–Dawley (SD) rats, SM1127 EPS increased the wound healing rate and stimulated tissue repair detected by macroscopic observation and histologic examination, showing the ability of SM1127 EPS to promote skin wound healing. In the skin frostbite experiment of SD rats, pretreatment of rat skin with SM1127 EPS increased the rate of frostbite wound healing and promoted the repair of the injured skin significantly, indicating the good effect of SM1127 EPS on frostbite injury prevention. These results suggest the promising potential of SM1127 EPS in the pharmaceutical area to promote skin wound healing and prevent frostbite injury.

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“…The results of the experiments confirmed that the PCL/ S . agilis nanofibers improved the wound healing and tissue regeneration (Jung et al, 2016).…”

Section: The Types Of Plant Compounds Used In Electrospinningmentioning

confidence: 99%

Medicinal plants used in wound dressings made of electrospun nanofibers

Fatehi

Abbasi

2020

J Tissue Eng Regen Med

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Nanofibers are a type of nanostructures, which due to their unique properties can be used in wound dressing, and electrospinning is a good way to produce them. The benefits of wound dressings made of electrospun nanofibers include a large surface area to volume ratio, high absorption of secretions from the wound, and high air permeability, mimicking the morphology of extracellular matrix (ECM) of the damaged tissue and the possibility of the gradual release of the drug agents loaded on nanofibers. Because of the adaptability of plants to the body, low side effects and the prevalence of antibiotic resistance, interest in using plants is increasing. Combining nanofibers with plants is a way to integrate the physical properties of the structure of nanofibers and the chemical and antibacterial properties of the plants. In recent years, many plants in the forms of extracts, essential oils, and pure active ingredients have been used in the electrospininng and production of nanofibercontaining plants; some of the plants may be a good choice for wound dressings made of electrospun nanofibers.

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Spirulina-PCL Nanofiber Wound Dressing to Improve Cutaneous Wound Healing by Enhancing Antioxidative Mechanism

Cited by 36 publications

References 40 publications

Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application

Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application

Promotion of Wound Healing and Prevention of Frostbite Injury in Rat Skin by Exopolysaccharide from the Arctic Marine Bacterium Polaribacter sp. SM1127

Medicinal plants used in wound dressings made of electrospun nanofibers

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