<i><scp>H</scp>elicobacter pylori</i> Induces Increased Expression of the Vitamin D Receptor in Immune Responses

Guo, Lihua; Chen, Wenguo; Zhu, Hongyan; Chen, Yu; Wan, Xingyong; Yang, Ningmin; Xu, Sheng; Yu, Chaohui; Chen, Lihua

doi:10.1111/hel.12102

Cited by 55 publications

(58 citation statements)

References 29 publications

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“…Recently, one of the most interesting reports on vitamin D by Guo et al . has shown that vitamin D demonstrates an antimicrobial effect against H. pylori. Guo et al .…”

Section: Discussionmentioning

confidence: 99%

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The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection

et al. 2018

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Background/Aim: Many studies have investigated risk factors other than antibiotic resistance linked to Helicobacter pylori (H. pylori) eradication failure. The aim of this study was to study the effect of serum levels of D) on eradication rates of H. pylori infection. Methods: This study included 150 patients diagnosed with H. pylori gastritis using magnifying narrow-band imaging endoscopy supported by stool antigen test. Serum 25-OH vitamin D levels were measured via the Enzyme-Linked Immune Sorbent assay (ELISA) method before starting eradication therapy of H. pylori infection. All patients were treated with clarithromycin-based triple therapy for 14 days. H. pylori eradication was determined via a stool antigen test performed 4 weeks after the end of therapy. According to the serum level of 25-OH vitamin D levels, the patients were divided into two groups: group I (sufficient) had a vitamin D level of ≥20 ng/mL, while group II (deficient) had a vitamin D level of <20 ng/mL. Results: Our results revealed that eradication was successful in 105 (70%) patients and failed in 45 (30%) patients. The mean 25[OH]D level was significantly lower in the eradication failure group compared to the successful treatment group (14.7 AE 4.5 vs 27.41 AE 7.1; P < 0.001). Furthermore, there were significantly more patients with deficient 25[OH]D levels in the failed treatment group, 30 (66.6%), compared to the successful group, 10 (9.5%) (P < 0.001). Conclusions: Our results demonstrated that 25-OH vitamin D deficiency may be considered a risk factor related to eradication failure of H. pylori infection. In addition, a further randomized trial to evaluate the effect of vitamin D supplementation in H. pylori eradication is mandatory.

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“…Recently, one of the most interesting reports on vitamin D by Guo et al . has shown that vitamin D demonstrates an antimicrobial effect against H. pylori. Guo et al .…”

Section: Discussionmentioning

confidence: 99%

“… has shown that vitamin D demonstrates an antimicrobial effect against H. pylori. Guo et al . found that vitamin D plays an important role in gastric mucosa homeostasis and host protection from H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection

et al. 2018

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“…H pylori infection leads to upregulation of the production of CAMP, which is directly regulated by binding of the VDR . Guo et al revealed that the expression of VDR and CAMP in the gastric epithelium is upregulated in the case of H pylori infection. Hosoda et al demonstrated another mechanism that the vitamin D3 decomposition product (VDP1) exerts an antibacterial action against H pylori but not against other bacteria.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Yang

et al. 2019

Helicobacter

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Background Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta‐analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication. Methods Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English‐language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. Results Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori‐positive patients was lower than H pylori‐negative (SMD = −0.53 ng/mL, 95% CI = (−0.91, −0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta‐analysis results were stable and reliable. Conclusions Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

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“…Vitamin D is known to be an important regulator of the immune response and may enhance the intracellular elimination of the replicating bacteria. Guo et al [31] reported that the vitamin D receptor significantly affected gastric mucosa homeostasis and protected the host from H. pylori infection. H. pylori infection causes gastric mucosal atrophy, which lowers serum ghrelin levels and causes motility dysfunction in the stomach [32].…”

Section: Discussionmentioning

confidence: 99%

Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease

Kwon

Jo²,

Lee³

et al. 2016

Neurodegener Dis

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Background and Objectives: Gastrointestinal dysfunction is a common non motor symptom in Parkinson's disease (PD). However, the potential association between vitamin D and gastroparesis in PD has not been previously investigated. The aim of this study was to compare vitamin D levels between drug-naive de novo PD patients with normal gastric emptying and those with delayed gastric emptying. Methods: Fifty-one patients with drug-naive de novo PD and 20 age-matched healthy controls were enrolled in this study. Gastric emptying time (GET) was assessed by scintigraphy, and gastric emptying half-time (T_1/2) was determined. The PD patients were divided into a delayed-GET group and a normal-GET group. Results: The serum 25-hydroxyvitamin D₃ levels were decreased in the delayed-GET group compared with the normal-GET and control groups (11.59 ± 4.90 vs. 19.43 ± 6.91 and 32.69 ± 4.93, respectively, p < 0.01). In the multivariate model, the serum 25-hydroxyvitamin D₃ level was independently associated with delayed gastric emptying in PD patients. Conclusions: Vitamin D status may be an independent factor for gastric dysmotility in PD. Although the underlying mechanism remains to be characterized, vitamin D status may play a role in the pathogenesis of delayed gastric emptying in drug-naive PD.

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Helicobacter pylori Induces Increased Expression of the Vitamin D Receptor in Immune Responses

Abstract: The expression of VDR and CAMP in the gastric epithelium is up-regulated in the case of H. pylori infection; thus, VDR plays an important role in gastric mucosa homeostasis and host protection from H. pylori infection.

Cited by 55 publications

References 29 publications

The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection

The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease

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