Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease

Kwon, Ki Young; Jo, Kyung-Wook; Lee, Moon Kyu; Oh, Minyoung; Kim, Eyu Nyong; Park, Jinse; Kim, Ji Sun; Youn, Jinyoung; Oh, Engseok; Kim, Hee-Tae; Oh, Moon Young; Jang, Wooyoung

doi:10.1159/000441917

Cited by 20 publications

(9 citation statements)

References 38 publications

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“…According to the Braak model of neuropathological staging of PD, the early stages 1 and 2 start from the medulla and the olfactory bulb [112], supporting a relationship between vitamin D and early PD. In addition to being associated with dementia and olfactory function in PD patients, serum 25(OH)D 3 concentrations can also affect the gastric emptying time [113] and orthostatic hypotension [114].…”

Section: The Relationship Between Vitamin D Level and Clinical Manifementioning

confidence: 99%

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Tan

et al. 2020

Transl Neurodegener

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In recent years, many studies have investigated the correlations between Parkinson's disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor (VDR) gene polymorphisms from PubMed, Web of Science, Cochrane Library, and Embase databases. We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity. Furthermore, higher vitamin D concentrations are linked to better cognitive function and mood in PD patients. Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent, but the FokI (C/T) polymorphism is significantly linked with PD. The occurrence of FokI (C/T) gene polymorphism may influence the risk, severity, and cognitive ability of PD patients, while also possibly influencing the effect of Vitamin D 3 supplementation in PD patients. In view of the neuroprotective effects of vitamin D and the close association between vitamin D and dopaminergic neurotransmission, interventional prospective studies on vitamin D supplementation in PD patients should be conducted in the future.

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Section: The Relationship Between Vitamin D Level and Clinical Manifementioning

confidence: 99%

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Tan

et al. 2020

Transl Neurodegener

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“…[ 15 ] Low serum 25(OH)D levels are associated with delayed gastric emptying time (GET) assessed by scintigraphy in Parkinson's disease patients that were divided into a delayed-GET group and a normal-GET group. [ 16 ]…”

Section: Itamin D For G mentioning

confidence: 99%

Is Vitamin D deficiency implicated in autonomic dysfunction?

Wadhwania

2017

J Pediatr Neurosci

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Dysautonomia, dysfunction of the autonomic nervous system, presents with heterogeneous clinical features from an imbalanced regulation of the sympathetic and parasympathetic nervous systems. Low Vitamin D levels can explain the heterogeneous clinical features of migraine headaches, cardiac and gastrointestinal dysfunction, and oxidative stress evident in dysautonomia patients. The role of Vitamin D in modulating pain sensitivity has been recently established. However, there is a lack of research and understanding regarding the association between Vitamin D deficiency and autonomic dysfunction. Vitamin D is a neuroactive hormone that modulates autonomic balance, regulating the sympathetic and parasympathetic nervous systems, and has multisystem benefits. The following review explores the literature and addresses the relationship between Vitamin D deficiency and autonomic dysfunction. Overall, this literature review implicates Vitamin D deficiency in autonomic dysfunction and elucidates the potential therapeutic role of Vitamin D in autonomic disorders. PubMed search was performed for English articles from 1996 to 2016. Following keywords: Vitamin D, autonomic dysfunction and orthostatic hypotension, Vitamin D receptor, migraine and traumatic brain injury, Vitamin D, cardiac and gastrointestinal disease, Vitamin D, glutathione, oxidative stress, and serotonin were included. Only articles reporting primary data relevant to the above question were included in the study.

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“…Epidemiological investigations have suggested that serum 25-hydroxyvitamin D (25(OH)D) level has significantly inverse associations with various neurological and neurodegenerative diseases [18–23]. However, little is known about 25(OH)D level in human cerebrospinal fluid (CSF).…”

Section: Introductionmentioning

confidence: 99%

Total 25-hydroxy vitamin D level in cerebrospinal fluid correlates with serum total, bioavailable, and free 25-hydroxy vitamin D levels in Korean population

et al. 2019

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Epidemiological investigations have suggested that serum 25-hydroxyvitamin D [25(OH)D] level has significantly inverse associations with various neurological and neurodegenerative diseases. However, little is known about 25(OH)D level in human cerebrospinal fluid (CSF). Thus, the aim of this study was to determine correlations of 25(OH)D level in CSF with serum total, bioavailable, and free 25(OH)D levels. This observational study enrolled a total of 117 subjects (58 patients with non-neurologic disease and 59 patients with neurologic disease) from 2017 to 2018. CSF and blood samples were collected in pairs. Total 25(OH)D levels in CSF and serum and vitamin D binding protein (VDBP) levels in serum were measured. We also performed GC genotyping for polymorphisms of rs4588 and rs7041 to calculate bioavailable and free 25(OH)D levels. CSF total 25(OH)D levels were compared with serum total, bioavailable, and free 25(OH)D levels. Mean total 25(OH)D concentrations in CSF and serum of all patients were 37.14 ± 7.71 and 25.72 ± 12.37 ng/mL, respectively. The mean total 25(OH)D concentration in CSF was generally 1.4-fold higher than that in the serum. Total 25(OH)D concentrations in CSF showed weakly positive but significant correlations with serum total, bioavailable, and free 25(OH)D concentrations (P = 0.022, P = 0.033, and P = 0.026, respectively). Serum total 25(OH)D concentration was also correlated with serum VDBP concentration (P = 0.017). However, total 25(OH)D levels in CSF of non-neurologic disease group and neurologic disease group were similar. Total 25(OH)D level in CSF has weakly positive but significant correlations with serum total, bioavailable, and free 25-hydroxy vitamin D levels in the Korean population. The distribution of CSF total 25(OH)D in Korean neurologic and non-neurologic disease patients was presented.

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Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease

Cited by 20 publications

References 38 publications

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Is Vitamin D deficiency implicated in autonomic dysfunction?

Total 25-hydroxy vitamin D level in cerebrospinal fluid correlates with serum total, bioavailable, and free 25-hydroxy vitamin D levels in Korean population

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