Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Abstract

Background Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta‐analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication. Methods Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English‐language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. Results Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori‐positive patients was lower than H pylori‐negative (SMD = −0.53 ng/mL, 95% CI = (−0.91, −0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta‐analysis results were stable and reliable. Conclusions Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

<p>Relationship Between <em>Helicobacter pylori</em> Infection, Serum Vitamin D3 Level and Spontaneous Abortion</p>

“…35 In contrast to these results, Nasri and Ardalan, and Bischof et al found a positive association of ages with VD3 level. 36,37 Yang et al 38 concluded that VD3 was a protective factor in H. pylori infection. Moreover, VD3 can improve the success rate of H. pylori eradication that supports our finding since were no changes in the level of VD3 about age (p > 0.05), but there was a significant difference in the mean of VD3 concentration between H. pylori-positive and H. pylori-negative in both groups (control and cases), in addition to other studies agree with our results.…”

Vitamin D Status and Gastric Cancer: A Cross-Sectional Study in Koreans

“…Chronic H. pylori infection was the major risk factor for GC [ 21 ]. A recent meta-analysis reported that sufficient vitamin D could be associated with decreased in Helicobacter pylori infection [ 6 ], and they found that vitamin D concentrations in H. pylori -positive patients were lower than those in H. pylori -negative patients. Furthermore, subjects with vitamin D deficiency was associated with lower success rates of H. pylori eradication [ 22 , 23 ].…”

“…An experimental study suggested that 1,25-(OH)D 3 can induce apoptosis in GC cells, suggesting its use in cancer therapy [ 5 ]. A recent meta-analysis reported that sufficient vitamin D could be associated with a decrease in H. pylori infection, a major risk factor for GC [ 6 ]. A review study by Du et al suggested that vitamin D may inhibit viability, proliferation and metastasis of gastric cancer cells and inhibit Helicobacter pylori infection and Helicobacter -related gastric cancer [ 7 ].…”

Correlation of registered drug packs in Greece with Maastricht V/Florence and Hellenic Helicobacter pylori infection treatment consensuses: A poor or a proper match?

“…VDR stimulated by the Hp-I induces human β-defensins which in high concentrations suppress Hp-biofilm activity. 5 Likewise, vitD appears to act directly as an antibacterial agent through stimulation of defensins and cathelicidins. In addition, studies in mouse models disclosed a protective role of a vitD upregulated protein 1 against Hp-related gastric malignancy.…”