<i>Salmonella</i>
            infections in cattle.

Wray, C.; Davies, RH

doi:10.1079/9780851992617.0169

Cited by 68 publications

(87 citation statements)

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“…signs (Wray & Davies 2000, Veling et al 2002. Classically, these signs have been useful in monitoring the evolution of the disease; however, changes in these parameters are difficult to quantify (Deignan et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Serum protein concentrations, including acute phase proteins, in calves experimentally infected with Salmonella Dublin

Silva

et al. 2011

Pesq. Vet. Bras.

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The aim of this study was to evaluate serum protein concentrations in calves experimentally inoculated with Salmonella Dublin. Twelve healthy 10 to 15-day-old Holstein calves were randomly allotted into two groups, control and infected with 10(8) CFU of Salmonella Dublin orally. The calves were subjected to physical evaluation and blood samples were collected shortly before administration of the bacteria and also 24, 48, 72, 96, 120 and 168 hours post-infection. The concentration of serum proteins was determined through sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). Thirty serum proteins ranging from molecular weight of 24,000 Da to molecular weight of 236,000 Da were detected. Serum concentrations of ceruloplasmin (125,000 Da), haptoglobin (45,000 Da), acid glycoprotein (40,000 Da) and a 34,000 Da protein were significantly increased in the experimentally infected calves, when compared with their concentrations in the control animals. Therefore, this study showed that S. Dublin infection could lead to the increase of certain serum proteins in calves.

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Section: Introductionmentioning

confidence: 99%

Serum protein concentrations, including acute phase proteins, in calves experimentally infected with Salmonella Dublin

Silva

et al. 2011

Pesq. Vet. Bras.

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“…Both groups of calves behaved in the same way. Affected animals with salmonellosis show high fever between 40.5 and 42 °C (Wray and Davies 2000), but the curves of temperature may vary according to the model used, because in general, Salmonella infections present a variety of clinical manifestations depending on age of the animal, serotype and pathogen dose (Sarwari et al, 2001). In this study, high fever became apparent soon after the administration of the pathogen, only 12 h post infection (figure 1) in contrast with other studies that observed a slower response, which led the animals to manifest fever among 24 and 72 h post infection (Paulin et al 2002, Silva et al 2010.…”

Section: Resultsmentioning

confidence: 99%

Faecal culturable microbiota, growth and clinical parameters of calves supplemented with lactic acid bacteria and lactose prior and during experimental infection with Salmonella Dublin DSPV 595T

Soto¹,

Frizzo²,

Signorini³

et al. 2015

Arch. med. vet.

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“…It was designed to investigate safety and efficacy of N-RM25 in animals in a particular age group (≤ 6 weeks old) because these animals are the most susceptible to both S. Dublin and S. Typhimurium infection [52,54]. In addition, salmonellosis in adult cattle caused by S. Dublin often results from the reactivation of infection in prolonged latent carriers due to various types of stress rather than being a direct result of recently acquired infection [35,54].…”

Section: Discussionmentioning

confidence: 99%

“…In cattle industries, introduction of modern intensive production and large-scale trading systems have resulted in an increased risk of animals being exposed to a wide range of Salmonella serovars [2,43,52], some of which have developed resistance to multiple antimicrobial agents [31,33]. To address this, a prophylactic approach to controlling a broad S. Typhimurium and 4-5 weeks for S. Dublin [52,54].…”

Section: Introductionmentioning

confidence: 99%

Intramuscular vaccination of young calves with aSalmonellaDublin metabolic-drift mutant provides superior protection to oral delivery

2008

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-In homologous and heterologous challenge trials using calves ≤ 6 weeks old, this comparative study investigated safety, in vivo behaviour and protective properties of oral and intramuscular vaccination with recently developed live attenuated Salmonella Dublin mutant N-RM25. Neither oral nor intramuscular vaccination produced unacceptable side effects. However, the vaccine strain was isolated for up to eight days from the faeces of orally vaccinated calves, but not intramuscularly vaccinated calves. Irrespective of the vaccination route, N-RM25 was isolated in low numbers (≤ 1 × 10 2 cfu/g) from the liver and spleen of calves euthanized at different time points post-vaccination. Vaccination by either route significantly reduced clinical signs and faecal shedding, prevented the development of systemic infection and protected calves from homologous lethal challenge conducted within 14 days post-immunisation. No challenge strain was isolated from major organs and the gut at 18 days post-challenge (except for a single mesenteric lymph node (MLN) specimen from the intramuscular group, but only following enrichment). Following heterologous challenge with a virulent Salmonella Typhimurium strain at 14 and 20 days post-immunisation, all vaccinated animals exhibited significantly fewer clinical signs and colonisation of the intestinal tract than non-vaccinated controls. When compared to oral vaccination, intramuscular vaccination significantly reduced the frequency of faecal shedding of S. Typhimurium (p = 0.0023) and markedly reduced colonisation of MLN. The findings indicate that intramuscular administration of N-RM25 was safer in terms of environmental contamination by the vaccine and provided better early onset protection in young calves following both homologous and heterologous challenge.Salmonella Dublin / metabolic-drift mutant / live attenuated vaccine / early onset protection / calf

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Salmonella infections in cattle.

Cited by 68 publications

References 0 publications

Serum protein concentrations, including acute phase proteins, in calves experimentally infected with Salmonella Dublin

Serum protein concentrations, including acute phase proteins, in calves experimentally infected with Salmonella Dublin

Faecal culturable microbiota, growth and clinical parameters of calves supplemented with lactic acid bacteria and lactose prior and during experimental infection with Salmonella Dublin DSPV 595T

Intramuscular vaccination of young calves with aSalmonellaDublin metabolic-drift mutant provides superior protection to oral delivery

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