SalaciaExtract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers

Abstract

Thirty-five healthy subjects were randomly assigned to different doses of Salacia chinensis extract (200 mg, 300 mg, and 500 mg SCE) capsules and compared with placebo. It is a placebo controlled randomized crossover design study. Subjects were given oral sucrose solution along with capsules and plasma glucose and insulin responses were analyzed. Blood samples were collected at 0, 30, 60, 90, 120, and 180 minutes after administration. AUC insulin significantly lowered after ingestion of SCE. No significant adverse events were observed. Reducing glucose and insulin is very important in reducing postprandial hyperglycemia.

Appetite and Gut Hormones Response to a Putative α-Glucosidase Inhibitor, Salacia Chinensis, in Overweight/Obese Adults: A Double Blind Randomized Controlled Trial

“…In the current study, SC displayed α-GI characteristics and decreased postprandial glucose and insulin, as expected [ 15 ]. In comparison to α-GI medications (i.e., mitglitol at 50 mg dose), that have been shown to reduce peak glucose by 14% and insulin by 55% at 60 min after a mixed meal test [ 8 ], SC decreased peak glucose by 6% and insulin by 11% at 60 min in the current study which may be partially attributed to our lower carbohydrate load.…”

“…The primary purpose of this study was to examine the effect of SC on hunger and this is the first trial to examine this outcome as well as gastrointestinal hormones in a randomized controlled crossover design. Previous studies with Salacia have focused on glycemic indices due to its α-GI properties, indicating improved glycemic indices in healthy and diabetic subjects, and animals have been reported [ 15 , 16 , 19 , 41 , 42 , 43 ]. A similar effect was also observed in this study in overweight/obese individuals who were recruited to address our primary aim to examine appetite.…”

“…Extracts of Salacia , a herbal plant that has α-GI properties, have been used in traditional Asian medicine for therapeutic and/or preventative treatment of various diseases, especially obesity and insulin resistance [ 14 ]. Studies have shown that Salacia acts as an α-GI to affect glucose metabolism, and that various species of Salacia , including Salacia Chinensis (SC), reduce postprandial plasma glucose and insulin in healthy subjects [ 15 ]. In addition, Salacia has been shown to reduce body weight in animal studies [ 16 ].…”

Scientific Exploration of Ingredients of katak Khadiradi Kashyayamfor Their Anti Diabetic Property

“…[10][11] Stimulation of?-cells to produce more insulin [12] and others may increase? -cells in the pancreas by activating regeneration of pancreatic cells.…”

Salacia chinensisexerts its antidiabetic effect by modulating glucose‐regulated proteins and transcription factors in high‐fat diet fed‐streptozotocin‐induced type 2 diabetic rats

“…Salacia chinensis seems to have a very exceptional polyphenolic content. It contains salacinol, salaretin, mangiferin, kotalanol, triterpenes, and ponkoranol (Jeykodi et al, 2016).…”